Showing 151–175 of 200 documents
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Walsh KF, McAulay K, Lee MH, Vilbrun SC, Mathurin L, et al.
…d in treatment-naive adults with drug-susceptible pulmonary tuberculosis in Port-au-Prince, Haiti, to assess the safety, bactericidal activity, and pharmacokinetics of nitazoxanide (NTZ). This was a prospective phase II clinical trial in 30 adults with pulmonary tuberculosis. Twe…
Hasan Ismail Sultan, Ibrahim Khalil Ibrahim
Background: Tuberculosis (TB) is an international public health problem. Drug resistant tuberculosis is a considerable global health risk, leading the ongoing TB epidemic and increasing the morbidity and mortality of TB worldwide. Incomplete and insufficient therapeutic regimens …
Ismaheel O. Lawal, Bernard Fourie, Matsontso Mathebula, Ingrid Moagi, Thabo Lengana, et al.
…96 Background: FDG PET/CT imaging at the completion of anti-tuberculosis therapy (ATT) may show residual metabolically activity (RMA) in patients considered cured at end of treatment (EOT) based on current standard of care diagnostic definitions. The significance of RMA as a risk…
Hendra Subroto, Ida Parwati, Bachti Alisjahbana, Coriejati Rita, Yuhpita Indah Efriyani, et al.
There are still limitations in the diagnosis of tuberculosis (TB), and developing monitoring tools to predict treatment outcomes for TB patients is important. Sputum collection is not only challenging but also has low sensitivity when used as a diagnostic specimen. Interferon gam…
Lun S, Tasneen R, Chaira T, Stec J, Onajole OK, et al.
…l wall-associated mycolic acid transporter of Mycobacterium tuberculosis In the present study, we characterized indoleamide effects on bacterial cell morphology and reevaluated pharmacokinetics and in vivo efficacy using an optimized oral formulation. Morphologically, indoleamide…
Edgardo A. Ferrán, Eliza Alexander, James Brown, A Gibertoni-Cruz, MCI Lipman, et al.
…rated that both Drug-sensitive (DS) and Drug-resistant (DR) tuberculosis (TB) can be treated effectively with short-course quinolone-containing combination therapy. Current WHO guidance includes using a four-month treatment with quinolones throughout for DS TB. The adverse event …
Nikonov SD, Bredikhin DA, Belogorodtsev SN, Schwartz YS
…ed for effective photodynamic inactivation of Mycobacterium tuberculosis at a constant dose of aluminum phthalocyanine. Reference laboratory drug-susceptible strain H37Rv and clinical isolates of M. tuberculosis with varying degrees of resistance to antibiotics were used. Suspens…
Colangeli R, Jedrey H, Kim S, Connell R, Ma S, et al.
…ckground Approximately 5% of patients with drug-susceptible tuberculosis have a relapse after 6 months of first-line therapy, as do approximately 20% of patients after 4 months of short-course therapy. We postulated that by analyzing pretreatment isolates of Mycobacterium tubercu…
Muhammad Shahzad
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is a deadly infectious disease and major global public health problem. Recent evidence from animal studies suggests that the microbiome plays a role in TB pathogenesis and immune response. However, until now, no simil…
Sejie GA, Mahomed OH
Background Eliminating Tuberculosis is one of the targets of Sustainable Development Goal Three. Decentralizing TB care beyond health facilities by leveraging community involvement is crucial for safeguarding effective tuberculosis care. In this study, we explored potential facil…
Reddy KP, Horsburgh CR, Wood R, Fields NF, Girouard MP, et al.
Rationale: Recent tuberculosis treatment trials failed to show that some 4-month (4m) regimens were noninferior to conventional 6-month (6m) regimens for a composite clinical outcome. Novel shortened regimens may still have important clinical and economic benefits in populations …
Kim HJ, Lee YJ, Song MJ, Kwon BS, Kim YW, et al.
Rifampicin is an important agent for tuberculosis treatment; however, it is often discontinued because of adverse reactions. The treatment regimen then can be administered as that for rifampicin-resistant tuberculosis, which can be toxic. We retrospectively reviewed 114 patients …
Veena Kiran Nambiar, H J GayathriDevi, Rachana Nayak
… the respiratory muscle strength in patients with pulmonary tuberculosis. <b>Participants:</b> Twenty six adults,newly diagnosed with pulmonary tuberculosis (Drug susceptible) visiting respiratory OPD consecutively. Age and gender matched subjects were recruited as controls. <b>M…
Ekaterina V Kurbatova, Kelly E Dooley, Wendy Carr, Jason E Stout, Eric L Nuermberger, et al.
…t shorten treatment duration for drug-susceptible pulmonary tuberculosis. **METHODS/DESIGN:** We describe the design of Tuberculosis Trials Consortium (TBTC) Study 38/CRUSH-TB (NCT05766267), an open-label multicenter international randomized controlled phase 2C trial that compar…
Jian Sun, Wenjie Wang, Jing Ding, Yusheng Cheng, Yunfeng Zhou, et al.
Abstract Background Duration of antituberculosis therapy (ATT) for managing female genital tuberculosis (FGTB) is controversial with the intermittent regimen no more advocated. We therefore conducted a prospective, real-world research to compare 6 months and 9 months of ATT. Meth…
Lauren A. Saag, Peter F. Rebeiro, Marcelo Cordeiro‐Santos, Afrânio Lineu Kritski, Bruno B. Andrade, et al.
…first two months of anti-TB therapy) is a predictor of poor tuberculosis (TB) treatment outcomes among HIV-negative populations, but the relationship has not been well studied in the context of HIV. We examined the association between HIV and weight change during the first two mo…
Li P, Wang B, Zhang X, Batt SM, Besra GS, et al.
…aluated for their in vitro activities against Mycobacterium tuberculosis and cytotoxicity against Vero cell line. Among these three series, the benzothiopyranone series displayed excellent antimycobacterial activity and low cytotoxicity. In particular, compound 6b exhibited poten…
Lee H, Bea S, Kim JH, Jeong HE, Jang SH, et al.
…tives The clinical importance of adhering to the regimen in tuberculosis patients has been widely investigated, but most studies were conducted in controlled settings and in limited populations. We aimed to measure the level of real-world adherence during intensive phase and inve…
Jian Sun, Wenjie Wang, Jing Ding, Yusheng Cheng, Yunfeng Zhou, et al.
Abstract Background Duration of antituberculosis therapy (ATT) for managing female genital tuberculosis (FGTB) is controversial with the intermittent regimen no more advocated. We therefore conducted a prospective, real-world research to compare 6 months and 9 months of ATT. Meth…
Haile H, Tema L, Anjulo A, Temesgen Z, Jerene D
…stimated incidence to be about 2-5% of overall total cases. Tuberculosis ARDS and septic shock are rare but carries extremely poor prognosis. Case summary A 27 year old male with advanced HIV disease with very low CD4 count presented to Wolaita Sodo University comprehensive speci…
Wang WF, Lu MJ, Cheng TR, Tang YC, Teng YC, et al.
Tuberculosis (TB), an infectious disease caused by Mycobacterium tuberculosis, kills over 1 million people worldwide annually. Development of drug resistance (DR) in the pathogen is a major challenge for TB control. We conducted whole-genome analysis of seven Taiwan M. tuberculos…
Saag L, Rebeiro P, Cordeiro-Santos M, Kritski A, Andrade B, et al.
…first two months of anti-TB therapy) is a predictor of poor tuberculosis (TB) treatment outcomes among HIV-negative populations, but the relationship has not been well studied in the context of HIV. We examined the association between HIV and weight change during the first two mo…
Subbaraman R, Thomas BE, Kumar JV, Lubeck-Schricker M, Khandewale A, et al.
Background Nonadherence to tuberculosis medications is associated with poor outcomes. However, measuring adherence in practice is challenging. In this study, we evaluated the accuracy of multiple tuberculosis adherence measures. Methods We enrolled adult Indians with drug-suscept…
Welekidan LN, Yimer SA, Skjerve E, Dejene TA, Homberset H, et al.
Background: Tuberculosis, mainly caused by Mycobacterium tuberculosis (Mtb), is an ancient human disease that gravely affects millions of people annually. We wanted to explore the genetic diversity and lineage-specific association of Mtb with drug resistance among pulmonary tuber…
Salazar-Austin N, Mulder C, Hoddinott G, Ryckman T, Hanrahan CF, et al.
… live in the household of someone with infectious pulmonary tuberculosis are at a high risk of tuberculosis infection and subsequent progression to tuberculosis disease. These individuals are prioritized for contact investigation and tuberculosis preventive treatment (TPT). The t…