Showing 126–150 of 200 documents
Sorted by hybrid relevance (keyword + semantic via RRF)
Mursalim Mursalim, Syahida Djasang, Muhammad Adil Awal, Sitti Hadijah, Kusnadi Kusnadi
Mycobacterium tuberculosis is a type of bacteria causing infectious desease called tuberculosis. According to the Makassar City Health Office, total tuberculosis (TB) patients in 2019 were 5,412 with 83% cure rate. The number of TB cases had dropped to 3,250 in 2020 with 85% cure…
Jees Sebastian, Anooja Thomas, Carly Levine, Riju Shrestha, Shawn Levy, et al.
Abstract Initial responses to tuberculosis treatment are poor predictors of final therapeutic outcomes in drug-susceptible disease suggesting that treatment success depends on features that are hidden within a small minority of the overall infecting Mycobacterium tuberculosis (Mt…
Dorman SE, Nahid P, Kurbatova EV, Phillips PPJ, Bryant K, et al.
… shorter course in patients with drug-susceptible pulmonary tuberculosis. Methods In an open-label, phase 3, randomized, controlled trial involving persons with newly diagnosed pulmonary tuberculosis from 13 countries, we compared two 4-month rifapentine-based regimens with a sta…
Muhammad Dayyab F, Iliyasu G, Garba Ahmad B, Aliyu Umar I, Musa Shuaib N, et al.
Background Mycobacterium tuberculosis with resistance to first line and second line anti tuberculous drugs is a serious setback in the treatment of tuberculosis (TB). The COVID-19 pandemic constitutes a serious threat that could unwind the recent gains made thus far in the contro…
Bart G J Dekkers, Huib A M Kerstjens, Helene W Breisnes, Diana J Leeming, Richard M Anthony, et al.
… reduce excessive inflammation and prevent tissue damage in tuberculosis are being investigated. Macrolides, including azithromycin, were shown to possess anti-inflammatory and immune-modulatory effects in addition to their antibacterial effects. In the current trial, we investig…
Richard Delali Agbeko Djochie, Berko Panyin Anto, Mercy Naa Aduele Opare-Addo
Abstract Background Achieving optimal rates of success in tuberculosis treatment is vital not just for the individual patient’s well-being but also for preventing the rise of drug-resistant tuberculosis strains. Unfavourable treatment outcomes pose significant challenges for heal…
A.O. Temitayo-Oboh, Ayotunde Sherif Azees, J.O. Amin, A.R. Salam, M.M. Fasiku
Background: Surveillance of tuberculosis treatment outcomes is very crucial in evaluating successes of tuberculosis (TB) intervention programmes as well as assessing progress towards achieving the Sustainable Development Goals target of ending TB infection by 2030. The study asse…
Gustavo Amorim, James Jaworski, Marcelo Cordeiro‐Santos, Afrânio Lineu Kritski, Marina C. Figueiredo, et al.
…enetic polymorphisms have been associated with risk of anti-tuberculosis treatment toxicity. We characterized associations with adverse events and treatment failure/recurrence among adults treated for tuberculosis in Brazil. Methods Participants were followed in Regional Prospect…
A.A. Danhausa, E.E. Daniel, C.J. Shawulu, Adamu Nuhu, L. Philemon
…e WHO efforts to promote a unified global control strategy, Tuberculosis remains a leading cause of infectious mortality. In this paper, a Mathematical Model for Tuberculosis Epidemic with Passive Immunity and Drug-Sensitivity is presented. We carried out analytical studies of th…
Fry S, Barnabas S, Cotton MF
Purpose of review Although tuberculosis (TB) causes much morbidity and mortality in children, diagnosis and treatment remain challenging. Recently, children have gained increasing attention in research and clinical trials driving improved contact management, case identification a…
Maïga Soumaïla, Ouédraogo Gafourou Arsène, Ali Moussa Mahaman Laouali, Ouattara Aïsseta Yasmine, Zonon Hamadé, et al.
Introduction: Tuberculosis remains a public health problem. The objective of this study was to investigate the comorbidities associated with this disease in the city of Ouagadougou. Methodology: This was a retrospective cohort study with a descriptive and analytical purpose, cond…
Ting Liu, Lei Zhang, Jiao Liu, Yao Liu, Anying Xiong, et al.
**BACKGROUND:** Tuberculosis (TB) remains a major global cause of mortality and is a leading cause of death among women of reproductive age (WRA). Untreated TB in this population endangers both maternal and neonatal health, yet the age-stratified burden and the shifting distribut…
Lun S, Xiao S, Zhang W, Wang S, Gunosewoyo H, et al.
…se 13 (Pks13) is an important enzyme found in Mycobacterium tuberculosis ( M. tuberculosis ) that condenses two fatty acyl chains to produce α-alkyl β-ketoesters, which in turn serve as the precursors for the synthesis of mycolic acids that are essential building blocks for maint…
Workie MG, Aycheh MW, Birhanu MY, Tsegaye TB
Background Tuberculosis treatment interruption is a failure of attending two scheduled appointments to collect the drugs in either phase of tuberculosis treatment. Even if TB treatment is crucial to achieve a cure and avoid the emergence of drug resistance, treatment interruption…
Wang T, Yang Q, Gao Y, Zhang R, Zhou C, et al.
…nifestations of rifampicin primary drug-resistant pulmonary tuberculosis in Liangshan Yi Autonomous Prefecture. Patients and methods A total of 100 inpatients with confirmed primary rifampicin-resistant pulmonary tuberculosis were recruited from January 2020 to December 2022 at a…
Т. Е. Кононова, О. И. Уразова, V. A. Serebryakova, С. П. Чумакова, O. A. Vasilyeva, et al.
…with different clinical and pathogenetic forms of pulmonary tuberculosis. Subjects and Methods. 165 pulmonary tuberculosis patients were examined. Venous blood was used for tests. Mononuclear leukocytes were isolated by centrifugation and monocytes were extracted and transformed …
I. A. Lapyreva, O. S. Ilyina, A. S. Goncharov, E. A. Grigorieva, М. А. Плеханова
…up in the complex therapy of patients with drug susceptible tuberculosis and HIV infection. Subjects and Methods. In 2020-2021, 40 patients with HIV infection and drug susceptible respiratory tuberculosis with a positive sputum test were examined in Moscow Regional Clinical TB Di…
Letemichael Negash Welekidan (9243532), Solomon Abebe Yimer (7860920), Eystein Skjerve (64644), Tsehaye Asmelash Dejene (5159135), Håvard Homberset (165283), et al.
<p>Background: Tuberculosis, mainly caused by Mycobacterium tuberculosis (Mtb), is an ancient human disease that gravely affects millions of people annually. We wanted to explore the genetic diversity and lineage-specific association of Mtb with drug resistance among pulmon…
Letemichael Negash Welekidan (9243532), Solomon Abebe Yimer (7860920), Eystein Skjerve (64644), Tsehaye Asmelash Dejene (5159135), Håvard Homberset (165283), et al.
<p>Background: Tuberculosis, mainly caused by Mycobacterium tuberculosis (Mtb), is an ancient human disease that gravely affects millions of people annually. We wanted to explore the genetic diversity and lineage-specific association of Mtb with drug resistance among pulmon…
M. Aharmim, Mohamed Lakhal, Nezha Reguig, J.E. Bourkadi
…re but potentially fatal vascular complication of pulmonary tuberculosis and an uncommon cause of massive hemoptysis. A 27-year-old female with no significant past medical history was admitted for a seven-month history of productive cough, intermittent mild hemoptysis, fever, nig…
Letemichael Negash Welekidan (9243532), Solomon Abebe Yimer (7860920), Eystein Skjerve (64644), Tsehaye Asmelash Dejene (5159135), Håvard Homberset (165283), et al.
<p>Background: Tuberculosis, mainly caused by Mycobacterium tuberculosis (Mtb), is an ancient human disease that gravely affects millions of people annually. We wanted to explore the genetic diversity and lineage-specific association of Mtb with drug resistance among pulmon…
Marie Wijk, Paolo Denti, Kamunkhwala Gausi, Bronwyn Myers, Tara Carney, et al.
**BACKGROUND:** Quantitative markers of tuberculosis disease burden are essential for assessing treatment response and optimizing therapeutic strategies. This study evaluated the impact of antimicrobial plasma drug levels on time-to-positivity (TTP) trajectories in patients with …
Serebryakova VA, Urazova OI, Novitsky VV, Vengerovskii AI, Kononova TE, et al.
…blood lymphocytes from patients with infiltrative pulmonary tuberculosis were studied in vitro. It was found that levofloxacin stimulated apoptotic cell death in tuberculosis. Addition of levofloxacin to cell suspension from patients with drug-susceptible form of tuberculosis led…
Hamid M, Brooks MB, Madhani F, Ali H, Naseer MJ, et al.
Objective Pakistan has a high pediatric burden of tuberculosis, but few studies describe the treatment experience of children with tuberculosis in Pakistan. We sought to identify risk factors for unsuccessful treatment outcomes in children with drug-susceptible tuberculosis ident…
Cicik Alfiniyah, Windarto Windarto, Nadiar Almahira Permatasari, Muhammad Farman, Nashrul Millah, et al.
Tuberculosis (TB), caused by Mycobacterium tuberculosis, stands as one of the most infectious diseases globally, predominantly affecting the lungs (known as pulmonary tuberculosis). It manifests in two primary forms based on bacterial drug sensitivity: drug-sensitive TB (DS-TB) a…