Showing 126–150 of 200 documents
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Samantha Pillay, Geraint Davies, Marty Chaplin, Margaretha de Vos, Samuel G. Schumacher, et al.
Background \nThe World Health Organization (WHO) End TB Strategy stresses universal access to drug susceptibility testing (DST). DST determines whether Mycobacterium tuberculosis bacteria are susceptible or resistant to drugs. Xpert MTB/XDR is a rapid nucleic acid amplificati…
Merchant SA, Shaikh MJS, Nadkarni P
… a 2050 target is feasible with a strategy combining better diagnostics, drugs, and vaccines to detect and treat both latent and active infection. The availability of rapid and highly sensitive diagnostic tools (Gene-Xpert, TB-Quick) will vastly facilitate population-level identi…
Seid A, Berhane N, Nureddin S
…ong RIF- and INH-resistant isolates would be valuable in TB diagnostics and treatment regimens, and could reduce the development and risk of MDR/XDR-TB drug-resistance patterns.
Singh P, Saket VK, Kachhi R
…ng complexity has led to the spurt in the development of TB diagnostics platforms. This review focuses on the new emerging technologies that have changed the diagnostics landscape.
World Health Organization. Regional Office for South-East Asia
…nal funding and secure concessionally priced qualityassured diagnostics and anti-TB drugs through international initiatives and other bilateral mechanisms, while also facilitating additional national manufacturers to meet international/WHO pre-qualification standards. Action by W…
Yin Mon Thant
Tuberculosis (TB) is well known as a major infectious disease and one of the top 10 causes of death worldwide. TB can affect anyone, everywhere but it has a predilection for those with diabetes, human immunodeficiency virus (HIV), smoking and undernutrition. Myanmar, with 54 mill…
Cho EJ, Kang MR, Kim JH, Lee JI, Son ES, et al.
…B is critical for early initiation of effective therapy. YD Diagnostics in South Korea recently developed the MolecuTech ® REBA MTB-XMDR test to rapidly detect multidrug-resistant TB (MDR-TB), pre-extensively drug-resistant TB (pre-XDR-TB) and resistance to second-line injectable…
Anil Regmi, Bishwa Bandhu Niraula, Abdus Sami, Vijay Kumar Jain, Gayatri Vishwakarma, et al.
…. Data extraction included demographics, clinical features, diagnostics, drug susceptibility, treatment protocols, surgical management, and outcomes. Twenty studies reported 1,242 drug-resistant cases: 1,032 spinal and 210 osteoarticular. MDR TB predominated, while pre-XDR/XDR ca…
Olha Konstantynovska, Petro Poteiko, Олександр Зіненко, Anton Rohozhyn, Ivan Hrek, et al.
…eStore Molecular Transport Medium® (Longhorn Vaccines & Diagnostics, San Antonio, TX). The isolates were transported from Kharkiv, Ukraine, to San Antonio, TX at ambient temperature. WGS was performed using an Illumina MiSeq platform. Bioinformatics analysis was conducted usi…
Saravanan M, Niguse S, Abdulkader M, Tsegay E, Hailekiros H, et al.
…ne laboratory tests and also lack of knowledge on molecular diagnostics. This review describes the disease etiology, pathogenesis, epidemiology, molecular mechanism and advanced molecular diagnostics for precision MDR-TB diagnosis.
Ginenus Fekadu, Tadesse Tolossa, Busha Gamachu Labata, Meseret Belete Fite, Tesfaye Regassa Feyissa, et al.
…rom earlier treatment initiation enabled by rapid molecular diagnostics. **METHODS:** We developed a decision-analytic model combining a short-term decision tree with a 10-year Markov model to simulate outcomes in a hypothetical RR-TB cohort. Three diagnostic strategies were com…
Cynthia Bin Eng Chee, David S.C. Hui
…calcitonin and C-reactive protein.2 Implementation of rapid diagnostics and biomarkers in healthcare settings may facilitate management of acute respiratory infections and decision-making on appropriate use of antiviral or antibiotic therapy, hospital LOS and prevention of nosoco…
Natarajan A, Beena PM, Devnikar AV, Mali S
Tuberculosis (TB), which is caused by bacteria of the Mycobacterium tuberculosis complex, is one of the oldest diseases known to affect humans and a major cause of death worldwide. Tuberculosis continues to be a huge peril disease against the human population and according to WHO…
Adwait Bendre, Dhruvi Shah, Riya Agrawal, Ira Shah
Abstract Background Extra-pulmonary tuberculosis presenting as a gluteal abscess is uncommon in children and poses diagnostic and therapeutic challenges. The emergence of drug-resistant tuberculosis further complicates management, leading to recurrent abscesses and bone involveme…
World Health Organization. Regional Office for South-East Asia
The World Health Organization's South-East Asia (SEA) Region has the highest burden of tuberculosis in the world. Appreciable progress has been made with TB control using the DOTS strategy, and several countries in the Region have reached the global targets. Renewed emphasis has …
Sonia Menon, Kobto Ghislain Koura
… AI-driven predictions in national TB programmes to enhance diagnostics, track trends, and strengthen public health surveillance. While promising for reducing transmission and supporting TB care in low-resource settings, these models require large-scale validation to ensure real-…
Andrey Zyubin, Anastasia I. Lavrova, Olga Manicheva, Marine Dogonadze, Vitaly Belik, et al.
Abstract The drug resistance of Mycobacterium tuberculosis (MbT) remains a serious challenge to global public health as extensively drug resistant tuberculosis usually leads to a lethal outcome. In the case of diseases with resistant strains, it is extremely important to identify…
Ibrahim Khalil, Noshin Anjum Tasmi, Md Imran Hossain, Mst Mahmuda Akter
…riven by expanded antiretroviral therapy (ART) and improved diagnostics. Gender-specific patterns revealed steeper declines for females, particularly in Southern Africa (2007-2014, APC: -12.97 %), compared to males (2007-2013, APC: -11.36 %), highlighting the impact of …
Yue Wang, Weibing Wang
… 1423-1429Crossref PubMed Scopus (11) Google Scholar better diagnostics, treatments, and innovative tools such as new tuberculosis vaccines are urgently needed. Although there have been rapid advances in tuberculosis vaccine clinical research over the past decade, mathematical mo…
Peter J. Holmberg, Zelalem Temesgen, Ritu Banerjee
1. Peter J. Holmberg, MD* 2. Zelalem Temesgen, MD† 3. Ritu Banerjee, MD, PhD‡ 1. *Division of Pediatric Hospital Medicine, Department of General Pediatric and Adolescent Medicine, and 2. †Division of Infectious Disease, Mayo Clinic, Rochester, MN 3. ‡Division of Pediatric Infecti…
Klaos K, Agejeva A, Hurt K, Kummik T, Kurve A, et al.
BACKGROUND This study evaluated the diagnostic performance of the thin-layer agar MDR/XDR-TB Colour Test (CT), a Mycobacterium tuberculosis complex (MTBC) detection and direct drug susceptibility testing (DST) method with routine sputum, bronchoalveolar lavage and pleural fluid s…
St George's Healthcare NHS Trust
Drug resistant tuberculosis is a growing problem world wide. The current methods for diagnosis are time consuming and may delay diagnosis and treatment for many weeks. In this study the investigators wish to take sputum samples from patients to see if the investigators can valida…
Foundation for Innovative New Diagnostics, Switzerland
FIND and partners intend to address the need for a multi- and extensively drug-resistant tuberculosis (M/XDR-TB) diagnostic solution for patients in settings with a high burden of drug-resistant tuberculosis (DR-TB) though the development, evaluation and introduction of an Xpert …
Klotoe BJ, Molina-Moya B, Gomes HM, Gomgnimbou MK, Oliveira Suzarte L, et al.
Several diagnostic tests are being developed to detect drug resistance in tuberculosis. In line with previous developments detecting rifampicin and isoniazid resistance using microbead-based systems (spoligoriftyping and TB-SPRINT), we present here an assay called TB-EFI detectin…
Neumann M, Reimann M, Chesov D, Popa C, Dragomir A, et al.
Objectives Early detection of treatment failure is essential to improve the management of drug-resistant tuberculosis (DR-TB). We evaluated the molecular bacterial load assay (MBLA) in comparison to standard diagnostic tests for monitoring therapy of patients affected by drug-res…