Showing 126–150 of 200 documents
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Oh CE, Ortiz-Brizuela E, Bastos ML, Menzies D
Background We conducted a review to compare the sensitivity, specificity, reproducibility, and predictive ability of QuantiFERON-TB Gold Plus (QFT-Plus) with that of QuantiFERON-TB Gold In-Tube (QFT-GIT; QIAGEN, Hilden, Germany) and other latent tuberculosis infection (LTBI) test…
Pape S, Gulma K, Shivalli S, Cleenewerck de Kiev L
Prison inmates are a high-risk group for tuberculosis (TB) infection and disease due to the increasing number of vulnerable fringe groups, risk factors ( e.g ., alcohol and drug addictions), contagious diseases (HIV, hepatitis), and their high-risk behavior. Compared to the gener…
Margarida Soares Resendes, Ana Paiva Santos, Daniela Meireles, Flávio G Pereira
Abdominal tuberculosis (TB) can present with the involvement of the peritoneum, stomach, intestinal tract, hepatobiliary tree, pancreas, perianal area, or lymph nodes. Peritoneal TB is one of the most challenging forms to diagnose and usually occurs through reactivation of latent…
Nakiboneka R, Margaritella N, Nyirenda T, Chaima D, Walbaum N, et al.
The World Health Organization End TB strategy aims for a 90% reduction of tuberculosis (TB) incidence by 2035. Systematic testing and treatment of latent TB infection (LTBI) among contacts of active TB patients is recommended as one of the ways to curtail TB incidence. However, t…
Zhang Y, Zhou G, Shi W, Shi W, Hu M, et al.
Background QuantiFERON-TB Gold Plus (QFT-Plus) is an important test that has emerged in recent years for detecting TB infection. We conducted a review to compare the sensitivity, specificity and positive rate of QFT-Plus with that of QuantiFERON-TB Gold In-Tube (QFT-GIT), T-cell …
Fernandes AF, Gonçalves LG, Bento M, Anjo SI, Manadas B, et al.
Tuberculosis (TB) is a transmissible disease listed as one of the 10 leading causes of death worldwide (10 million infected in 2019). A swift and precise diagnosis is essential to forestall its transmission, for which the discovery of effective diagnostic biomarkers is crucial. I…
Siddig Ibrahim Abdelwahab, Manal Mohamed Elhassan Taha, Hazem Mathkour, Edrous Alamer, Saleh Mohammad Abdullah, et al.
**BACKGROUND AND OBJECTIVES:** Tuberculosis (TB) remains a major global health challenge, driving the need for innovative approaches in diagnosis and drug development. The integration of artificial intelligence (AI), particularly machine learning (ML), has enabled significant adv…
Paula Mesquita, Daniela Ribeiro Alves, Joana Martinez, Mónica Mata, Ana Micaela Martins, et al.
**BACKGROUND:** Cryptococcosis is an opportunistic fungal infection that causes disseminated disease in immunocompromised patients. Peritoneal involvement is rare and diagnostically challenging. **CASE REPORT:** A 76-year-old man with Crohn's disease on infliximab and previously…
Ortiz-Brizuela E, Apriani L, Mukherjee T, Lachapelle-Chisholm S, Miedy M, et al.
Background We compared 6 new interferon-γ release assays (IGRAs; hereafter index tests: QFT-Plus, QFT-Plus CLIA, QIAreach, Wantai TB-IGRA, Standard E TB-Feron, and T-SPOT.TB/T-Cell Select) with World Health Organization (WHO)-endorsed tests for tuberculosis infection (hereafter r…
Queen Mary University of London
Tuberculosis (TB) is an infectious disease that is caused by bacteria (bugs). The infection is passed on when a patient with active lung TB coughs bugs into the air, which are then breathed in by an uninfected person. In 90% of people who get infected, the TB infection remains do…
Bertoncello C, Ferro A, Ferraresso A, Mascarello M, Fonzo M, et al.
Background In 2016, 362 753 migrants reached Europe by sea. Most of migrants come from high tuberculosis (TB) burden countries and travel in conditions that increase the risk for communicable diseases. The goal of WHO End TB Strategy is to end global epidemic by 2035. Management …
Odiko Ae, Mmemek-Abasi Etim, Oloyede IP, S Onukak, A Adegboye
Background: Tuberculosis (TB) remains a significant global health challenge, causing considerable morbidity and mortality worldwide. Despite advancements in healthcare, TB continues to prevail, particularly in resource-limited settings. Understanding latent tuberculosis infection…
Buttle TS, Hummerstone CY, Billahalli T, Ward RJB, Barnes KE, et al.
Background The monocyte-to-lymphocyte ratio (MLR) has been advocated as a biomarker in tuberculosis. Our objective was to evaluate its clinical value and associations. Methods Blood counts, inflammatory markers and clinical parameters were measured in patients with and those scre…
Yahav D, Gitman MR, Margalit I, Avni T, Leeflang MMG, et al.
Background This is a systematic review and meta-analysis of diagnostic test accuracy studies to assess the predictive value of both tuberculin skin test (TST) and interferon-gamma release assays (IGRA) for active tuberculosis (TB) among solid organ transplantation (SOT) recipient…
Klautau GB, da Mota NVF, Salles MJC, Burattini MN, Rodrigues DS
Background In developing countries, tuberculosis (TB) is a major public health problem and the leading cause of death among patients with HIV (Human Immunodeficiency Virus). Until 2001, the tuberculin skin test (TST) was the only available tool for the diagnosis of latent tubercu…
Karen S. Baker, Jessica Potter
<h3>Background</h3> Tuberculosis (TB) is a common infection worldwide, existing on a spectrum between latent infection and active disease. Screening and treating people at-risk of TB reduces the incidence of developing active TB in the future and is an important part of England’s…
Escalante P, Vadiyala MR, Pathakumari B, Marty PK, Van Keulen VP, et al.
…esting tools for LTBI and describe promising biomarkers and diagnostics for the spectrum of asymptomatic TB. Following the negative results of a recent clinical trial for a biomarker-guided preventive therapy approach, we also suggest some treatment options for incipient TB.
Namugga JV, Musubika C, Niwagaba S, Mayito J, Sande OJ
Objective To evaluate the diagnostic accuracy of anti-Mycobacterial Protein 51 (MPT51) antibodies in latent Tuberculosis (TB) detection among asymptomatic Human Immune Virus (HIV) positive individuals using Interferon Gamma Release Assay (IGRA) (QuantiFERON-TB Gold Plus) as the g…
Verónica Bravo Villa, Emmanuel Martínez Moreno, Nidia Zapata
Introduction Patients with AML are inmmunocompromised because of the disease itself and the use of chemotherapy, increasing endemic opportunistic infections. The main complication is secondary infectious diseases, which we have to consider TB. In cancer patients infected with TB …
Chongxing Z, Yuanchun L, Yan H, Dabin L, Zhezhe C, et al.
Background Latent tuberculosis infection (LTBI) co-infected with human immunodeficiency virus (HIV) is more likely to develop into active tuberculosis (ATB), recombinant Mycobacterium tuberculosis fusion protein ESAT6/CFP10 (EC-Test) is a latest developed method for LTBI. Compare…
Borkowska-Tatar D, Krasińska M, Augustynowicz-Kopeć E
The aim of the study was to evaluate the QuantiFERON-TB Gold Plus (QFT-Plus) test usability in the identification of latent tuberculosis infection (LTBI) in children and the determination of features associated with tuberculin skin test (TST) and QFT-Plus-positive results concern…
Harish Goyal, Srinivas Ananth Kumar, Anirudh Abu Srinivasan, Manikya Y S, Dhritiman Chakraborty
Tumor necrosis factor-alpha (TNF-α) inhibitors, such as adalimumab, are integral in the managing refractory ankylosing spondylitis (AS). However, their immunosuppressive effects elevate the risk of reactivation of latent tuberculosis (TB), especially extrapulmonary TB (EPTB…
Wu X, Chen P, Wei W, Zhou M, Li C, et al.
Background To investigate the diagnostic value of the interferon-γ release assay (IGRA) for detecting tuberculosis (TB) infection in patients with Behçet's disease (BD). Methods We retrospective analyzed the data collected from 173 BD patients hospitalized between 2010 and 2015. …
Анна Старшинова, Е. А. Кушнарева, Anna M. Malkova, I. F. Dovgalyuk, D.А. Kudlаy
…n course in adults and children, as well as capabilities of diagnostics, treatment and prevention of COVID-19. It is possible to allocate groups of high risk of development of severe forms of disease (elderly people, people with latent tuberculosis infection, adult patients with …
Luo J, Zhang M, Yan B, Li F, Guan S, et al.
Objective We aimed to identify plasma cytokine biomarkers that differentiate the infection stages of Mycobacterium tuberculosis (MTB). Methods This study included a total of 227 subjects consisting of active tuberculosis (ATB) patients, latent tuberculosis infection (LTBI) indivi…