Showing 126–150 of 200 documents
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Li Y, Jia W, Lei G, Zhao D, Wang G, et al.
Background Both osteoarticular tuberculosis (OA-TB) and inflammatory arthritis can lead to osteoarticular structural damage. These conditions exhibit similar symptoms, physical signs, and imaging features. Rapidly and accurately diagnosing OA-TB in patients with inflammatory arth…
Glassman I, Nguyen KH, Giess J, Alcantara C, Booth M, et al.
Tuberculosis (TB) prevalence is increasing in developed nations and continuing to cause significant mortality in low- and middle-income countries. As a result of the uptick in cases, there also exists an increased prevalence of extrapulmonary TB. TB is caused by Mycobacterium tub…
Nogueira BMF, Krishnan S, Barreto-Duarte B, Araújo-Pereira M, Queiroz ATL, et al.
…arget product profiles for biomarker- or biosignature-based diagnostics using point-of-care tests from easily accessible specimens such as urine or blood. Here we review and summarize progress made in the development of pathogen- and host-based biomarkers for active TB diagnosis.…
Tuan Manh Ha, Thu Cam Huynh, Tung Viet Le, Anh Tuan Nguyen, Cong Hai Nguyen
**BACKGROUND:** Tuberculous pleural effusion (TPE) is a common form of extrapulmonary tuberculosis and remains difficult to diagnose, particularly when distinguishing it from malignant and parapneumonic pleural effusions. Although pleural fluid adenosine deaminase (ADA) is widely…
Radina Dimitrova, Yoanna Ignatova, Lyuben Stoev, Mira Siderova
Introduction. Tuberculous (TB) lymphadenitis is the most frequent extrapulmonary manifestation of Mycobacterium tuberculosis infection, with predominant involvement of the cervical lymph nodes (LN). Bilateral LN enlargement in elderly patients, especially in the presence of a thy…
Bineeta Kashyap, Krishna Sarkar, Sharanya LNU, Debamita Banik, Puneeta Hyanki
Background: Extrapulmonary tuberculosis (EPTB) diagnosis is difficult due to its subclinical or nonspecific clinical symptoms, paucibacillary nature, and difficulties in obtaining qualified pathological specimens for Mycobacterium tuberculosis detection. Given the paucibacillary …
Stadelman-Behar AM, Tiffin N, Ellis J, Creswell FV, Ssebambulidde K, et al.
No accurate and rapid diagnostic test exists for tuberculous meningitis (TBM), leading to delayed diagnosis. We leveraged data from multiple studies to improve the predictive performance of diagnostic models across different populations, settings, and subgroups to develop a new p…
Rasheed W, Rao NA, Adel H, Baig MS, Adil SO
Introduction Tuberculosis is a major health problem in Pakistan. The prevalence of pulmonary as well as extrapulmonary tuberculosis is quite high. Tuberculin skin test, radiological imaging, and sputum smear microscopy have limitations in the diagnosis of tuberculosis. Xpert MTB/…
Mehwish Kiran, Syed Mazhar Ali Naqvi, Arslan Iqbal, Huma Batool, Abdur Rahman Zaheer Butt, et al.
Objective: To find out the diagnostic precision of GeneXpert and AFB smear by fluorescent microscope for diagnosis of pulmonary tuberculosis keeping the culture as a gold standard. Methodology: A survey performed in the Pulmonology and Pathology Department, Lahore General Hospita…
Guocan Yu, Xudong Xu, Yanqin Shen, Yuyang Ling
**BACKGROUND:** Extrapulmonary tuberculosis (EPTB) is a serious type of tuberculosis (TB) which can cause systemic clinical manifestations. Rapid diagnosis of EPTB for intervention is of great importance. Nanopore sequencing as a third-generation gene sequencing method is a new k…
Louise Preston, Alexander Thompson, Susan Baxter, Duncan Chambers, Paul Collini, et al.
**BACKGROUND:** Delays in diagnosing and treating tuberculosis (TB) have significant implications. We undertook a rapid review to explore factors associated with delays at all stages of the diagnostic and treatment pathways in low-burden settings. **METHODS:** We searched databa…
Anandraj vaithy K, Keerthika Sri E, S. Shanmugasamy .K, S Sowmya
Tuberculosis remains one of the major causes of morbidity and mortality in developing countries like India despite intense health campaigning and Government Programmes. Tuberculous lymphadenitis is the most common extrapulmonary manifestation of tuberculosis; the incidence is sti…
Quiterie Boscals de Réals, Ugo Françoise, Nicolas Vignier, Hervé Delacour, Frédéric Méchaï
**PURPOSE:** Diagnosing extrapulmonary tuberculosis (EPTB) - including pleural, peritoneal, pericardial, meningeal forms - remains challenging due to the insufficient sensitivity of smear microscopy (SM), mycobacteriological culture, and nucleic acid amplification test (NAAT). Th…
Serena Vita, Claudia Piccolo, Gaetano Maffongelli, Alberta Villanacci, Nicoletta Fusco, et al.
**BACKGROUND:** Extrapulmonary tuberculosis (TB) remains a diagnostic challenge due to its nonspecific clinical manifestations, low bacterial burden, and the need for invasive procedures to obtain diagnostic samples. Breast TB, a particularly rare form, can closely mimic other co…
Chan KKP, Lee YCG
Purpose of review Tuberculous pleuritis (TBP) is one of the most common types of extrapulmonary tuberculosis. We highlight the latest epidemiology of TBP, the heterogeneity of its presentation and the performance of different diagnostic strategies. Recent findings There are diffe…
D. Pavan, H. Ravish, S. Nagarathna, M. Nethravathi, K Sangeetha Seshagiri
Although tuberculosis (TB), caused by the bacteria Mycobacterium tuberculosis, affects the lungs in the majority of cases, it can also affect other parts of the body. It is most common in young children and HIV-infected patients, but it can also be found in adults with the condit…
Subhamay Adhikary, Sneha Leo, Antara Banerjee, Surajit Pathak, Meenakshi Narasimhan, et al.
**BACKGROUND:** Diagnosis and treatment of Tuberculosis (TB), particularly delay in diagnosis of TB poses significant challenges in its eradication. The exploration of new biomarkers is urgently required for TB diagnosis and treatment. This study aimed to investigate the serum le…
Klaudia Knecht-Gurwin, Iwona Chlebicka, Lukasz Matusiak, Zdzisław Woźniak, Andrzej Bieniek, et al.
: Cutaneous tuberculosis (CTB) represents a rare extrapulmonary manifestation ofinfection, accounting for approximately 1-2% of all tuberculosis cases. Despite its low incidence, CTB remains diagnostically challenging due to its clinical polymorphism and resemblance to other gran…
Girija Shankar Udgata, S.K. Dash, Sasmita Meher, ANANYA UDGATA, Smruti Ranjan Hota
Background and Aims: Tuberculosis (TB) is severe infectious disease caused by Mycobacterium tuberculosis and imposes significant morbidity and mortality. Early diagnosis of active TB forms pulmonary and extrapulmonary is very important and the diagnostic methods such as culture t…
Xiang Chen, Giovanni Ladu, Vincenzo Lai, Leonardo Antonio Sechi, Paola Molicotti
Tuberculosis (TB) remains a global health crisis, hampered by significant diagnostic delays, particularly for extrapulmonary TB and in resource-limited settings. The development of point-of-care tests (POCTs) meeting the WHO's ASSURED criteria is crucial. This prospective laborat…
Xiang ZB, Leng EL, Cao WF, Liu SM, Zhou YL, et al.
Objective The utility of metagenomic next-generation sequencing (mNGS) in the diagnosis of tuberculous meningitis (TBM) remains uncertain. We performed a meta-analysis to comprehensively evaluate its diagnostic accuracy for the early diagnosis of TBM. Methods English (PubMed, Med…
Madhukar Pai
Globally, tuberculosis (TB) remains a major public health concern with an estimated 8.8 million new cases and 1.3 million deaths reported in 2012. 1 India accounts for 25% of this global TB burden, and for a third of the 'missing cases' that do not get diagnosed or notified. 1 Al…
Hindol Maity, Supriya Meshram, Keshao Hiwale, Pratibha Narang
…ularly interspaced short palindromic repeats (CRISPR)-based diagnostics. The review also underscores the importance of integrating human, animal, and environmental data within the One Health framework. It advocates for expanded molecular speciation in clinical workflows and impro…
Lisa Kurver, Timothy Seers, Suzanne van Dorp, Reinout van Crevel, Gabriele Pollara, et al.
Abstract Background Tuberculosis (TB) can induce secondary hemophagocytic lymphohistiocytosis (HLH), a severe inflammatory syndrome with high mortality. To improve insight into optimal diagnostic and treatment strategies, we integrated all published reports of adult HIV-negative …
He J, Xiong J, Huang Y
Background The timely diagnosis of tuberculosis through innovative biomarkers that do not rely on sputum samples is a primary focus for strategies aimed at eradicating tuberculosis. miR-29 is an important regulator of tuberculosis pathogenesis. Its differential expression pattern…