Showing 126–150 of 200 documents
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Christopher A. Berger, R. Crowder, A. Kityamuwesi, Noah Kiwanuka, M. Lamunu, et al.
… We conducted a pragmatic, stepped-wedge cluster randomized trial including all adults treated for drug-susceptible pulmonary TB at 18 health facilities across Uganda over eight months (December 1, 2018-July 31, 2019). Facilities were randomized to switch from routine (control pe…
Gashu KD, Gelaye KA, Lester R, Tilahun B
… home. Methods We conducted a two-arm randomised controlled trial on adult patients with TB during the continuation phase. In the intervention arm, patients received routine care plus phone-based weekly pill refilling and daily medication reminders. In the control arm, participan…
Lifan Zhang, Yujie He, Wenwen Wang, Lijun Wu, Xiaoxia Zuo, et al.
…cted a multicenter, open-label, randomized, non-inferiority trial at nine tertiary general hospitals in China. Eligible participants were adults (18-70 years) with high-risk rheumatic diseases and LTBI undergoing immunosuppressive therapy. Patients were randomized (1:1) to receiv…
Bhargava A, Bhargava M, Meher A, Teja GS, Velayutham B, et al.
…ia. RATIONS is a field-based, cluster-randomised controlled trial evaluating the effect of providing nutritional support to household contacts of adult patients with microbiologically confirmed pulmonary tuberculosis in Jharkhand, India, on tuberculosis incidence. The patient coh…
Van Hoving DJ, Griesel R, Meintjes G, Takwoingi Y, Maartens G, et al.
…ential sources of heterogeneity in test accuracy, including clinical setting, ultrasound training level, and type of reference standard. Search methods We searched for publications in any language up to 4 April 2019 in the following databases: MEDLINE, Embase, BIOSIS, Science Cit…
Huang-Shen Lin, Ming‐Shyan Lin, Yu‐Shiun Tsai, Yu‐Sheng Lin
…LHIV. Methods We searched PubMed, Embase, Cochrane library, clinicaltrials.gov, and the International Clinical Trials Registry Platform for all literature and ongoing trials from their inception until November 30th, 2022. We performed a meta-analysis of the efficacy, adhesion rat…
Fernández-Ruiz M, Aguado JM
…ndications of available agents are reviewed, as well as the clinical evidence coming from clinical trials and observational registries. We discuss the impact of patient- and disease-related factors influencing the occurrence of infection. Finally, strategies for risk minimization…
Tamuzi JL, Ayele BT, Shumba CS, Adetokunboh OO, Uwimana-Nicol J, et al.
… HIV/TB co-infected or TB patients, screening algorithm and clinical management. Methods We conducted an electronic search of potentially eligible studies published in English in the Cochrane Controlled Register of Trials, PubMed, Medrxiv, Google scholar and Clinical Trials Regis…
Nicola Foster, Amare Worku Tadesse, M Belachew, Mamush Sahlie, Christopher Finn McQuaid, et al.
…fectiveness analysis using data from the cluster randomised trial that evaluated the implementation of labels and pillbox followed by differentiated care to support tuberculosis treatment adherence in 78 health facilities in Ethiopia. We estimated the costs, cost per disability-a…
Amare W Tadesse, Mamush Sahile, Nicola Foster, Christopher Finn McQuaid, Gedion Teferra Weldemichael, et al.
…rrence. **METHODS:** We did a pragmatic cluster-randomised trial in Ethiopia. 78 health facilities (clusters) were randomised (1:1:1) to smart pillbox, medication labels, or standard of care. Adults aged 18 years or older with drug-sensitive pulmonary tuberculosis on a fixed-dos…
Gong X, He Y, Zhou K, Hua Y, Li Y
…ntly improve the accuracy of tuberculosis (TB) detection in clinical settings, with advanced sensitivity and specificity. Early detection of TB can be challenging, but Xpert has improved the efficacy of the diagnostic process. Nevertheless, the accuracy of Xpert varies according …
Bediang G, Stoll B, Elia N, Abena JL, Geissbuhler A
…between the fifth and the sixth months of treatment. Future trials should focus on reducing the dropout rate. Trial registration The trial was registered on the Pan-African Clinical Trials Registry ( PACTR201307000583416 of 22 July 2013) and the protocol was published.
Jorge D. Machicado, Georgios I. Papachristou
… field of pancreatology, this has translated into increased clinical and research efforts to decrease the burden, morbidity, and mortality associated with benign inflammatory disorders and pancreatic cancer. As a result, there has been a tremendous progress in our understanding o…
Manabu Suzuki, Satoki Hatano, Chie Morita, Akinari Tsukada, Akane Ishida, et al.
…ucted a retrospective observational study to understand the clinical characteristics of patients with cryptogenic hemoptysis (CH). **METHODS:** The clinical characteristics, angiographic findings, and immediate and long-term efficacies of BAE were retrospectively analyzed in 36 …
Hirabayashi R, Nakayama H, Yahaba M, Yamanashi H, Kawasaki T
…IGRAs may be useful for detecting TB infection in children. Clinical trial registration The review protocol was prospectively registered with the University Hospital Medical Information Network Clinical Trials Registry (UMIN000046737).
O'Rourke J, Townsend CL, Milanzi E, Collins IJ, Castro H, et al.
… Methods We searched MEDLINE, Embase, the Cochrane Library, clinical trial registries, reference lists and relevant conferences to identify literature published January 2009-March 2021. We included clinical trials and observational studies assessing the efficacy/effectiveness or …
Ai Luo, Xuemei Liu, Qiongqiong Hu, Mei Yang, Hongli Jiang, et al.
…Systematic Reviews, Cochrane Central Register of Controlled Trials will be searched from inception to 1 March 2022 for eligible randomised controlled trials that investigating the effects of NAC on exacerbations, health-related quality of life, lung functions, sputum volume and c…
Crider K, Williams J, Qi YP, Gutman J, Yeung L, et al.
…w Types of studies Inclusion criteria Randomized controlled trials (RCTs) Quasi-RCTs with randomization at the individual or cluster level conducted in malaria-endemic areas (areas with ongoing, local malaria transmission, including areas approaching elimination, as listed in the…
Aisya Rezki Noeriman, Sumarheni Sumarheni, Aliya Nur Hasanah, Lika Apriani, Prayudi Santoso, et al.
…B) treatment remains limited. This scoping review evaluated clinical studies on TDM and its impact on TB treatment outcomes. **METHODS:** A scoping review was performed using a systematic search in PubMed, Embase, Web of Science, ClinicalTrials.gov, and the World Health Organiza…
Fox GJ, Nhung NV, Sy DN, Hoa NLP, Anh LTN, et al.
…tnam. Methods We performed a cluster-randomized, controlled trial at clinics in 70 districts (local government areas with an average population of approximately 500,000 in urban areas and 100,000 in rural areas) in eight provinces of Vietnam. Health workers at each district clini…
Yang Y, Cai J, Wang X, Zhao K, Lei Z, et al.
…We conducted a double-blinded placebo-controlled randomized trial in 360 pulmonary tuberculosis patients with concurrent diabetes or prediabetes. The participants were randomly assigned to receive a daily nutrition package (112 kcal, 9 g protein, and micronutrients) or a daily pl…
Lin H, Lin Y, Zheng Y, Liu Z, Chang C
… to help TB patients quit smoking, and we will evaluate the clinical efficacy of this application by using a randomised controlled trial (RCT). Methods and analysis This is a two-step study. In the first step, we will develop a smartphone application based on an interactive appli…
Cox SR, Kadam A, Atre S, Gupte AN, Sohn H, et al.
…e I effectiveness-implementation non-inferiority randomized trial to compare the effectiveness, cost-effectiveness, and feasibility of two ACF strategies among individuals who have completed TB treatment and their household contacts (HHCs). Methods We will enroll 1076 adults (≥ 1…
Dogar O, Keding A, Gabe R, Marshall AM, Huque R, et al.
…hods We did a randomised, double-blind, placebo-controlled, trial at 32 health centres in Bangladesh and Pakistan. Eligible patients were adults (aged >18 years in Bangladesh; aged >15 years in Pakistan) with pulmonary tuberculosis diagnosed in the previous 4 weeks, who smoked to…
Jennifer Phillips, Wayne Hing, Rodney Pope, Ashleigh Canov, Nicole Harley, et al.
…individuals with bronchiectasis are routinely prescribed in clinical practice and recommended by international guidelines, especially during an acute exacerbation. However, there is limited evidence of the efficacy of these techniques during an exacerbation to improve sputum expe…