Showing 126–150 of 200 documents
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Mahmoud M, Tan Y
…ion rate from person to person. Despite the availability of vaccines and several anti-TB,TB infection continues to increase. Global resistance to TB remains the greatest challenge. There has not been extensive research into a new treatment and management strategy for TB resistanc…
McDonald K, Rodriguez A, Muthukrishnan G
Bacterial infections continue to represent a significant healthcare burden worldwide, causing considerable mortality and morbidity every year. The emergence of multidrug-resistant bacterial strains continues to rise, posing serious risks to controlling global disease outbreaks. T…
Nur Qomariyah, Widowati Widowati, Eka Triyana
Tuberculosis is an infectious disease with transmission through the air and droplets of infected people. The problem of spreading and treating tuberculosis needs some development. The model used in this study is a model of development, in which infected individuals are divided in…
Kurnia Fajar Chasanah, Ika Kana Trisnawati, Wahyudi Istiono
Background: Multi-drug resistant tuberculosis (MDR-TB) is a serious health problem with high morbidity and mortality. The identification of risk factors is needed to prevent the incidence TB-MDR. Objective: To identify the risk factors of TB-MDR in the Special Region of Yogyakart…
Chin KL, Anibarro L, Sarmiento ME, Acosta A
Globally, it is estimated that one-quarter of the world's population is latently infected with Mycobacterium tuberculosis (Mtb), also known as latent tuberculosis infection (LTBI). Recently, this condition has been referred to as tuberculosis infection (TBI), considering the dyna…
Muluneh Assefa, Abiye Tigabu, Teshome Belachew, Belay Tessema
INTRODUCTION: Community-acquired pneumonia is associated with higher morbidity, hospitalization, and mortality in adults. Likewise, antimicrobial resistance has increased in recent decades in Ethiopia. Therefore, this study was aimed to determine the bacterial isolates, their ant…
Svetlana Degtyareva, O. O. Vinokurova, В. Н. Зимина
…or latent tuberculosis infection and its treatment, and new vaccines development. Feasibility and efficacy of these measures are to be investigated in the context of settings with different DM and TB prevalence and available resources.
Benson Olu Akinshipe, Anthony Chukwuka Nwaobi, Emmanuel Babatunde Adedeji, Friday Alfred Ehiaghe, Herbert Obi Okpala
Host immune response against Mycobacterium tuberculosis (MTb) is mediated by cellular immunity in which cytokines and MTb-specific T cells play an important role. The detection of MTb and discrimination between different states of MTb infection is possible by immunodiagnostic tes…
Chinenye Esther Okoro-Ani, Confort Nnenna Akujobi, Iniekong Philip Udoh, Stellamaris Ojiuzor Ibhawaegbele, Charles Ikechukwu Ezema, et al.
Tuberculosis, one of the oldest recorded human afflictions, is still one of the biggest killers among the infectious diseases, despite the worldwide use of a live attenuated vaccine and several antibiotics. This study was designed to assess the resistance rate distribution of MDR…
Manish Dwivedi, Sutanu Mukhopadhyay
…um</italic> <italic>tuberculosis</italic>. Albeit there are vaccines and drugs available to treat the disease, Multidrug-resistant TB (MDR-TB) is still one of the most critical challenges for the investigators where the development of efflux systems makes them resistant to drugs.…
O B Nechaeva
The objective: analysis of tuberculosis situation among the pediatric population of Russia. Subjects: the data from Federal Statistics Forms no. 8, 30, 33, 47, and 61 were studied. The number of those died is presented as per the data of Rosstat. Research methods: epidemiological…
Rafael Laniado-Laborín
One-third of the world's population is infected with M. tuberculosis. It is from this vast pool of infected people where the new cases of active disease originate. Most of these cases of latent infection are found in low-income countries where national tuberculosis programs conce…
Ayman Elshayeb, Nihad Mohammed Ahmed, Karimeldin Mohamed Ali Salih, Osama Abu Zaid Nugoud, Abd Allah Elnayeb Yagoub, et al.
Abstract Introduction: Sudan, especially Eastern States are very poor areas at great risk of endemic and communicable diseases particularly tuberculosis. The reasons for the spread and transmission of this disease include medical, economical and geographical issues, besides Sudan…
E Lupu, Stela Kulcitkaia, Evelina Lesnic
Tuberculous pleural effusion (TPE) accounted 0.6% of all TB forms in children diagnosed in 2018 in R. Moldova. The study aim was to assess the role of bacteriological, biochemical, cytological criteria and ADA in pleural fluid for diagnosing of TPE. A group of 135 children diagno…
Bobba S, Khader SA
…R TB would aid the development of rational therapeutics and vaccines for patients with MDR TB.
Dooley KE, Rosenkranz SL, Conradie F, Moran L, Hafner R, et al.
Background Bedaquiline and delamanid are the first drugs of new classes registered for tuberculosis treatment in 40 years. Each can prolong the QTc interval, with maximum effects occurring weeks after drug initiation. The cardiac safety and microbiological activity of these drugs…
Alexandrova LA, Khandazhinskaya AL, Matyugina ES, Makarov DA, Kochetkov SN
Tuberculosis (TB) is the oldest human infection disease. Mortality from TB significantly decreased in the 20th century, because of vaccination and the widespread use of antibiotics. However, about a third of the world's population is currently infected with Mycobacterium tubercul…
Kumar GS, Sameena P, Karthik V, Ghanate N
Background According to Indian TB report 2020, 66,225 MDR/RR-TB cases were detected in India, 56,569 (85%) were put on treatment, and 40,397 (75%) were initiated on shorter drug regimens at the time of diagnosis. In the absence of an effective vaccine, there is an urgent need for…
Bhattacharya S, Ghosh P, Banerjee D, Banerjee A, Ray S
…drugs, while two drug targets were membranebound, ideal for vaccines. Spectrum analysis identified one broad-spectrum and 11 narrowspectrum targets. This study would, therefore, instigate designing novel therapeutics for antivirulence therapy, which have the potential to serve as…
Cojocaru E, Cojocaru C, Cojocaru E, Oancea CI
Background The unprecedented exodus in the history of the European Union of more than 6 million Ukrainian refugees (May 13, 2022) is a cause for concern and could lead to a new difficult situation in terms of infectious disease control. Following the SARS-CoV-2 pandemic, Europe i…
Andama A, Somoskovi A, Mandel B, Bell D, Gutierrez C
Tuberculosis (TB) recently surpassed HIV/AIDS as the deadliest infectious disease. Despite some advancements in technologies and programs, TB remains a global health epidemic that, without significant gains in better diagnostic and management, will not abate. This review describe…
Harichander S, Wiafe E, Mensah KB, Bangalee V, Oosthuizen F
Background Tuberculosis (TB) is considered one of the top 10 causes of death worldwide and the leading cause of death from a single infectious agent. Multidrug-resistant (MDR) TB can affect people of all age groups, including children (aged 0-15 years). However, very little is kn…
Hermann C, Karamchand L, Blackburn JM, Soares NC
…exposed proteins that could be targeted by therapeutics and vaccines. A variety of experimental approaches and mycobacterial species have been used in proteomic studies thus far. Here we provide for the first time an extensive summary of the different approaches to isolate the my…
Aftab A, Afzal S, Qamar Z, Idrees M
… effective or for the development of novel potent drugs and vaccines to better treat the drug-resistant TB. Moreover, this study will be help in disease control program.
Shadrach BJ, Kumar S, Deokar K, Singh GV, Hariharan, et al.
Background Diagnosis and management of multidrug-resistant tuberculosis (MDR-TB) remains a global challenge and is associated with high morbidity and mortality. Burden of TB among symptomatic household contacts of MDR-TB is not extensively studied and screening of symptomatic con…