Showing 126–150 of 200 documents
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Mochammad Fadjar Wibowo, Mutiara Indriani
The fight against tuberculosis (TB) in Southeast Asia is a long and arduous one, as the region accounts for about 45% of global TB cases. Member states of the Association of Southeast Asian Nations (ASEAN) have also been consistently and proactively involved in various TB control…
Kilinc AA, Onal P, Oztosun B, Yildiz M, Adrovic A, et al.
Objective The use of tumor necrosis factor inhibitors (anti-TNF) has a risk of activating latent tuberculosis infection (LTBI). This study was performed to investigate LTBI according to tuberculin skin test (TST) size and to determine the frequency of tuberculosis (TB) in bacillu…
Druszczynska M, Seweryn M, Wawrocki S, Pankowska A, Godkowicz M, et al.
Background Children have an increased risk of developing active tuberculosis (TB) after exposure to Mycobacterium tuberculosis ( M.tb ), and they are more likely to develop the most severe forms of TB. Rapid diagnosis and treatment of latent M.tb infection (LTBI) is essential to …
Tareef Fadhil Raham
Abstract Background Emergence of new multisystem inflammatory syndrome in children (MIS-C) is thought to be associated with COVID-19 pandemic. Covid-19 morbidity and mortality variances among countries have been suggested by previous works to be influenced by BCG and previous lat…
Md Abdul Kuddus, Sazia Khatun Tithi, Thitiya Theparod
Tuberculosis (TB) remains a major global health challenge, including in Thailand, where both asymptomatic and symptomatic cases sustain transmission. The disease burden increases treatment complexity and mortality, requiring integrated care and coordinated policies.We developed a…
Vasilyeva IA, Aksenova VA, Kazakov AV, Kiseleva YY, Maryandyshev AO, et al.
Introduction The tuberculin skin test has significant limitations for use in individuals vaccinated with BCG. The presence in the genome of Mycobacterium tuberculosis of the RDI region, which is absent in the genome of Mycobacterium bovis BCG and most non-tuberculous mycobacteria…
Brett K, Severn M
There are 2 accepted tests for the identification of latent tuberculosis infection (LTBI), the tuberculin skin test (TST) and the interferon gamma release assay (IGRA). TST involves an intradermal injection of a purified protein derivative into the lower part of the arm and waiti…
Chiappini E, Zaffaroni M, Bianconi M, Veneruso G, Grasso N, et al.
Aim This study evaluated the prevalence of infectious diseases and immunisation status of children adopted from Africa. Methods We studied 762 African children referred to 11 Italian paediatric centres in 2009-2015. Clinical and laboratory data were retrospectively collected and …
Aleksey V. Kazakov, MD, Anastasia G. Samoylova, MD, Valentina A. Aksyonova, Prof.
The aim of this study is to test the recombinant tuberculosis skin test in the previously BCG vaccinated healthy adults with low risk of TB development, to determine the test specificity. Recombinant tuberculosis allergen (RTA) is a recombinant fusion protein CFP10-ESAT6 produce…
Scordo JM, Aguillón-Durán GP, Ayala D, Quirino-Cerrillo AP, Rodríguez-Reyna E, et al.
Background Aging increases the risk of tuberculosis (TB) and its adverse outcomes, but most studies are based on secondary analyses, and few are in Hispanics. Diabetes is a risk factor for TB in adults, but its contribution in the elderly is unknown. We aimed to identify the role…
Layton ED, Yu KKQ, Smith MT, Scriba TJ, De Rosa SC, et al.
CD1 tetramers loaded with lipid antigens facilitate the identification of rare lipid-antigen specific T cells present in human blood and tissue. Because CD1 proteins are structurally non-polymorphic, these tetramers can be applied to genetically diverse human populations, unlike …
Wendy Thanassi
Abstract Introduction The reservoir of active tuberculosis infection is latent tuberculosis (TB) infection (LTBI). This reservoir can be denuded by occupational health (OH) professionals aggressively testing new hires - in all occupations - and following that testing with LTBI sh…
Georgieva A, Atanassova A, Mirchev M
Objective Although the use of anti-tumor necrosis factor-alpha (anti-TNF-α) agents is highly effective in achieving and maintaining remission in patients with moderate-to-severe IBD, they place the patient at increased risk of developing opportunistic infections, including new ca…
Renata Báez-Saldaña, Lourdes García‐García, Leticia Ferreyra-Reryes, Luis Pablo Cruz‐Hervert, Norma Mongua-Rodríguez, et al.
The TST was administered to 113 cases with PTB and 194 household contacts. The gold standard was the bacteriological confirmation in patients. The household contacts were classified as true positives according to the selected cutoff point. Those with purified protein derivative r…
Fatma Merve Koçak, Berru Yargı Özkoçak
**BACKGROUND:** Tumor necrosis factor-alpha (TNF-α) inhibitors, particularly adalimumab (ADA), are widely used for ocular inflammatory diseases but may increase the risk of tuberculosis reactivation. Data on latent tuberculosis infection (LTBI) screening and outcomes are li…
Vekemans J, O'Brien KL, Farrar J
Johan Vekemans, Katherine O'Brien, and Jeremy Farrar discuss recent breakthroughs in the search for a highly effective tuberculosis vaccine.
Upton CM, van Wijk RC, Mockeliunas L, Simonsson USH, McHarry K, et al.
Background BCG vaccination prevents severe childhood tuberculosis (TB) and was introduced in South Africa in the 1950s. It is hypothesised that BCG trains the innate immune system by inducing epigenetic and functional reprogramming, thus providing non-specific protection from res…
Kiltz U, Celik A, Tsiami S, Buehring B, Baraliakos X, et al.
…ation recommendations requiring a complete documentation of vaccines. The mean vaccination score was 13.3±4.2 with 5.7% of patients having a low, 43.9% a moderate, 47.0% a good and 3.3% a high score. Conclusions The majority of CIRD patients are n0t sufficiently vaccinated agains…
Maria Norrby
<p>Sweden is a low burden country for tuberculosis (TB). New cases occur mainly among immigrants from countries with a higher TB prevalence. Most persons infected with TB (latent TB) will not develop disease (active TB). Prolonged treatment is necessary and can cause severe…
Archivel Farma S.L.
…on, therefore reduce the time required to cure. Therapeutic vaccines do not interfere directly with the causative organism and hence, they are not involved in the development of drug resistance. Therapeutic vaccination would also be beneficial for DS-TB as it could increase the r…
Fukuta Y, Giordano T
…man papilloma virus and the dates of receipt of hepatitis A vaccines, hepatitis B vaccines, pneumococcal conjugate vaccines, pneumococcal polysaccharide vaccines and influenza vaccines (Figure 1). Providers can select their plan for each health maintenance item based on these dat…
Wu Y, Cai M, Ma J, Teng X, Tian M, et al.
… to the failure remains unknown. In this study, CTT3H-based vaccines, namely DMT adjuvanted CTT3H subunit or DNA vaccine (pCTT3H-DMT), and recombinant adenovirus rAdCTT3H were constructed. Protective efficacy and immunogenicity of BCG prime-CTT3H based boosters were compared in C…
Dereck Tait, MD, Angelique Luabeya, MD
This is a Phase I/IIa, double-blind, randomized, placebo-controlled, dose- and regimen-finding study in healthy adults with and without LTBI, who are BCG-vaccinated, HIV negative, and have no history or evidence of TB disease. The investigational product is AERAS-456 at 3 dose le…
Delia Goletti, Seif Al-Abri, Giovanni Battista Migliori, Cecilia S. Lindestam Arlehamn, Pranabashis Haldar, et al.
…e discuss several prevention issues. Prevention starts with vaccines [8da Costa C Benn CS Nyirenda T Mpabalwani E Grewal HMS Ahmed R et al.Perspectives on development and advancement of new tuberculosis vaccines.Int J Infect Dis. 2024; https://doi.org/10.1016/j.ijid.2024.106987Ab…
Wang C, Lu J, Du W, Wang G, Li X, et al.
The high global burden of tuberculosis (TB) underscores the urgent need for an effective TB vaccine since the only licensed Bacillus Calmette-Guérin (BCG) vaccine is ineffective in preventing adult pulmonary TB and affords no protection against latent TB infection (LTBI). Herein …