Showing 126–150 of 184 documents
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Al Yazidi LS, Marais BJ, Wickens M, Palasanthiran P, Isaacs D, et al.
Background Sydney has a large and highly mobile immigrant community. The pattern of paediatric tuberculosis (TB) disease in this highly cosmopolitan city is not well documented. Methods We reviewed data on all children notified with TB in New South Wales (NSW), Australia, from Ja…
Manyelo CM, Solomons RS, Walzl G, Chegou NN
…toward the identification of targets that may be useful for vaccines or host-directed therapeutics. In this review, we summarize the current knowledge about the immunology and pathogenesis of TBM and summarize the literature on existing and new, especially biomarker-based, approa…
Minotti C, Costenaro P, Donà D, Zuliani M, Bosa L, et al.
Background The incidence of pediatric inflammatory bowel disease is increasing. tumor necrosis factor alpha inhibitors medicines improved the prognosis of affected subjects. Nonetheless, a proportion of patients do not respond or lose response to treatment. Newer biologics, like …
A Jacob, M Vera Ricaurte, C Anyanechi, S Benzaquen
Abstract Introduction Sarcoidosis is a multisystem granulomatous disease characterized by non-caseating granulomas and bilateral hilar lymphadenopathy. However, environmental pneumoconiosis may closely resemble sarcoidosis radiologically and histologically, creating a diagnostic …
Seddon JA, Tugume L, Solomons R, Prasad K, Bahr NC
Tuberculous meningitis (TBM) results from dissemination of M. tuberculosis to the cerebrospinal fluid (CSF) and meninges. Ischaemia, hydrocephalus and raised intracranial pressure frequently result, leading to extensive brain injury and neurodisability. The global burden of TBM i…
Rai TK, Chakravarty J, Kashyap S, Chatterjee S, Tiwari VD, et al.
Seasonal outbreaks of acute encephalitis syndrome (AES) with high case fatality rates have been commonly reported among adults in India. With an increase in Japanese encephalitis virus (JEV) vaccination, the etiology of AES is also changing. However, most studies on AES in India …
Kasinathan A, Serane VK, Palanisamy S
Tuberculosis (TB) is a disease of diverse manifestations. In children, neurotuberculosis is the severest form, which when left untreated can have deleterious consequences. There has been reports on pediatric TB meningitis manifesting with fever and seizures, altered sensorium or …
Lavadi RS, Sandeep BV, Banga MS, Halhalli S, Kishan A
Background Spinal intramedullary tuberculoma (IMT) is a rare manifestation of extrapulmonary tuberculosis (TB). Presentation of TB in the pediatric age group is a significant contributor to mortality. Case description A young vaccinated girl presented to the neurosurgery departme…
Elisha Shrestha, Ashish Tamang, Namrata Pradhan, Sanjan Kumar Sah, Binay Yadav, et al.
Abstract Cutaneous tuberculosis (TB) is a rare manifestation of extrapulmonary TB, accounting for only 1–1.5% of cases. Among its various forms, cutaneous miliary TB is exceptionally uncommon and often presents with nonspecific clinical features. This makes early diagnosis challe…
Laura Marinela Ailioaie, Constantin Ailioaie, Gerhard Litscher
Tuberculous meningitis (TBM) is the most lethal form of tuberculosis (TB), with reported short-term mortality of 20–69% for patients on treatment and five-year deaths exceeding 58%. The World Health Organization has reported a new record of approximately 8.3 million new cases of …
Xuefeng Peng, Yue Li, S. Jin, Qiang Wang
Extracellular vesicles have been a hot research topic in recent years, and the diagnostic and therapeutic value of LprG and LAM, two key markers present in extracellular vesicles secreted by Mycobacterium tuberculosis or Mycobacterium tuberculosis-infected immune cells, in tuberc…
Karolina D. Witt
…s and the role of selected TB antigens in the design of new vaccines.
Biruk Mulugeta, Robel Nasser Abafita, Dagmawi Mulugeta Fentaw, Eden Kebede Telila, Mekdes Molla Wollel, et al.
Background: Tuberculosis has plagued humanity for centuries, causing significant suffering. References to the disease may even be found in the Old Testament, dating back to when the Israelites lived in Egypt, where TB was widespread. The term "tuberculosis" was first introduced b…
Ery Olivianto, Agustin Iskandar, Triyana Dian Dhuha Akmaly, Sarah Zoraya Mirza, Maxie Felix Jahono
Background: Tuberculosis (TB) remains a major global health challenge, particularly among children. Diagnosing pediatric TB is complicated due to nonspecific symptoms and the difficulty of obtaining sputum samples for microbiological confirmation. Immunological tests, such as the…
Biruk Mulugeta
Background: Tuberculosis has plagued humanity for centuries, causing significant suffering. References to the disease may even be found in the Old Testament, dating back to when the Israelites lived in Egypt, where TB was widespread. The term "tuberculosis" was first introduced b…
Christine Ritchie
Introduction Tuberculous Meningitis (TBM) and Disseminated Tuberculosis (DTB) are severe forms of Tuberculosis that cause significant mortality and morbidity in children. Moreover, tuberculosis is disproportionately high in low and middle-income countries. We sought to systematic…
Sayla Aktar Chowdhory, Sabina Sultana, Shampa Rani Pal, Sadia Islam Reya, Konika Rahman, et al.
Tuberculosis (TB) is a major public health problem in Bangladesh. In this case-control retrospective study, a total of 348 patients, either with pulmonary TB (PTB) or extrapulmonary TB (EPTB), were surveyed from April 2020 to January 2023 from five different districts of Banglade…
Luh Indrasuari, Sang Ayu Kompiyang Indriyani
Miliary TB is one of the manifestations of TB with incidence 3-7% among all TB cases and 13% can spread to brain as Tuberculous Meningitis (TBM). This case report discusses a case of miliary TB complicated with meningoencephalitis in children under two years of age without histor…
Ihsan Asrir, Kamal Wifaq, Loubna Tahri, Sara Soltani, El Abdeljalil Kholti
Abstract Introduction Tuberculosis (TB) is a human disease caused by Mycobacterium Tuberculosis, and transmitted by airborne pathway. The objective of this study is to draw up the epidemiological and professional profile of healthcare workers (HCWs) with TB at the Ibn Rochd Unive…
Deepika Jalal, Nidhi Negi, Rajat Kala, Archana Kandari, Anamika Saxena, et al.
Tuberculosis, one of the oldest recorded human afflictions, still one of the biggest killers among the infectious diseases, despite the worldwide use of a live attenuated vaccine and several antibiotics. The Aim of this study was to isolate Mycobacterium tuberculosis from various…
Anmol Sharma, Aditya Puniyani, C. V. Gopal Raju, Robin Choudhary
Sir, A 20-year-old female with no significant past medical history presented with a 1-month history of intermittent fever (maximum temperature 101°F), malaise, loss of appetite, holocranial headache, and loose stools. There was no history suggestive of any localization and no his…
Nikita Narayanan Pooja Thashnath
Lupus vulgaris is a form of cutaneous tuberculosis. It occurs in previously sensitized individuals with a moderate degree of immunity against tubercle bacilli. The lesions are acquired by hematogenous spread from an underlying tuberculosis focusor by direct inoculation. [1] Cutan…
Rahana Pervin, M Atiqul Haque, Tanjela Bushra, Syeda Afroz, Sudipta Das, et al.
Abstract Introduction: Childhood tuberculosis (TB) is one of the common causes of child mortality and morbidity in Bangladesh. The study aimed to assess the risk factors of extrapulmonary TB (EPTB) and pulmonary TB (PTB) in children and compare those with PTB amongst children. Ma…
Agbeko Djagadou Kodjo, Djalogue Lohanimpo, Tchala Abou-Bakari, Toyi Tchamdja, Abago Balaka, et al.
Décrire la tuberculose extrapulmonaire au CHU Sylvanus Olympio de Lomé.C'était une étude rétrospective et descriptive sur une période de 2 ans, de novembre 2020 à octobre 2022, des cas de tuberculose extrapulmonaire diagnostiqués et traités au CHU SO de Lomé.Soixante-six cas ont …
Nadine Asir, Noor Al-Sulaiti, Abdusamea Shabani, Atqah Abdul Wahab
<b>Background:</b> Extrapulmonary and pulmonary mycobacterium tuberculosis (MTB) are rarely seen in patients with cystic fibrosis (CF). No cases of Pott9s disease have been reported in CF. Case report We describe a female adolescent with cystic fibrosis who is 13 years old and on…