Showing 126–150 of 200 documents
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J Servello, P de Colombani, L Dall'Olio, G Gargioni, M C B Raviglione
…ncrease the chance of successfully and rapidly adopting new regimens where they are most needed. Our analysis is based on: i) stakeholder engagement efforts undertaken in the context of UNITE4TB (a global clinical trial consortium for development of new TB drugs and regimens), ii…
Nisa Maria, Annisa Lazuardi Larasati, Indri Yuliani Hamdani, Jin-Gun Cho, Jan-Willem C Alffenaar
…dies that reported AE data for bedaquiline-pretomanid-based regimens. In total, 14 studies from various countries were included in the analysis, comprising seven clinical trials, six implementation studies and one pharmacovigilance study. AE detection methods differed between cli…
Klauss Villalva-Serra, Beatriz Barreto-Duarte, Moreno M Rodrigues, Artur T L Queiroz, Julio Croda, et al.
…iers towards the expansion of shorter patient-friendly drug regimens. In 2019, a Unitaid-led deal reduced rifapentine costs by over 70%, facilitating Brazil's implementation of 3 months of rifapentine+isoniazid (3HP), a short-course TPT regimen, in its public health system. We ev…
Lorenzo Guglielmetti, Uzma Khan, Gustavo E. Velásquez, Maëlenn Gouillou, Amanzhan Abubakirov, et al.
… controlled clinical trial to compare five 9-month all-oral regimens including bedaquiline (B), delamanid (D), linezolid (L), levofloxacin (Lfx) or moxifloxacin (M), clofazimine (C) and pyrazinamide (Z), to the standard (control) for treatment of fluoroquinolone-susceptible RR-TB…
Natalia Yatskevich, Elmira Gurbanova, G. L. Gurevich, E. M. Skryagina
…ective: to evaluate the safety of 39- and 24-week treatment regimens in the patients with rifampicin-resistant tuberculosis (RR-TB). Subjects and Methods. Cohorts of patients with RR-TB were treated with the following regimens: 550 patients received modified short course treatmen…
He Y, Li X
Background Tuberculosis (TB) is one of the serious epidemics that highly threaten the global public health. To explore the treatment effect of Levofloxacin, Moxifloxacin, and Gatifloxacin contained in the conventional therapy regimen for pulmonary tuberculosis. Methods Medline, P…
Rimal B, Panthi CM, Xie Y, Belz DC, Ignatius EH, et al.
…hibits potent in vitro and in vivo activity against Mab. As regimens containing multiple antibiotics are required to produce a durable cure for Mab disease, we assessed efficacies of three three-drug combinations in a pre-clinical mouse model of pulmonary Mab disease to identify …
Black TA, Buchwald UK
…nagement of drug-resistant tuberculosis, providing all-oral regimens with favorable safety profiles. The Nix-TB and ZeNix trials of a bedaquiline - pretomanid - linezolid regimen demonstrated for the first time that certain forms of drug-resistant tuberculosis can be cured in the…
Nicholas Paton
…he TRUNCATE-TB Management Strategy with 4 potential boosted regimens (180 per arm, total 900 with the standard TB management strategy arm). The boosted regimens include new drugs (licensed drugs, repurposed from other indications) and optimized doses of standard drugs, selected b…
Sanne M.H. Zweijpfenning, Stephan E.P. Kops, Martin J. Boeree, Saskia Kuipers, Jakko van Ingen, et al.
Mycobacterium avium complex pulmonary disease (MAC-PD) is the most frequent non-tuberculous mycobacterial (NTM) disease . Outcomes of the currently recommended treatment regimen for MAC-PD, rifampicin (R), ethambutol (E) and macrolides (M), are poor. In case of extensive fibro-ca…
Yaoyao Sun, Bonam Cao, Wen‐Wang Rao, Xinwei Li, Bao-zhu Yu, et al.
…is study was to evaluate the efficacy and safety of two FDC regimens in two provinces with a high tuberculosis burden. A total of 2,353 newly diagnosed active pulmonary TB patients were recruited from Shandong Province (n=1,223) and Jilin Province (n=1,130). Participants received…
Tutik Kusmiati, Anita Nur Charisma, Nur Prasetyo Nugroho, Soedarsono Soedarsono
Drug-resistant tuberculosis (DR-TB) is a worldwide global burden and related to poor treatment outcomes. Monitoring the progress of DR-TB treatment can be carried out microscopic with Acid-Fast Bacilli (AFB) sputum smear and assessed from the beginning or the first time the patie…
Ritika Singla, Neetu Sharma
…ic infections (OIs) in HIV-positive patients on ZLN and TLE regimens. Materials and Methods: This retrospective record-based study was conducted at anti-retroviral therapy (ART) center of a tertiary care hospital on 150 charts of patients on ZLN (Group A) and TLE (Group B) regime…
Soutrik Kundu, Sarvan Singh
…daquiline-based regimen. Therefore, the efficacy of shorter regimens with novel drugs such as Bedaquiline and Delamanid in drug-resistant TB of the spine must be analysed. The present case series highlights the outcomes of a newer Bedaquiline-based antitubercular regimen in posto…
Lusi Indriani, Gita Iftitah Renitia, Lusi Agus Setiani
…at is nausea (55.1%). The use of standard conventional drug regimens mostly in Z, E, Eto, Km, Lfx, Cs (Pyrazinamide, Ethambutol, Ethionamide, Kanamycin, Levofloxacin, Cycloserine) of 51.4%. The chi-square analysis showed no significant correlation between the treatment duration a…
A. Mittal, Gunjan Mittal, Vivek Kumar Yadav, Surinder Kumar Bansal
The study aimed to evaluate the effectiveness, safety, and feasibility of this regimen in patients with rifampicin-resistant TB. This prospective observational study was conducted at K.D. Medical College, Hospital, and Research Center, Mathura, over two years. The study evaluated…
Iryna Makoyda, Мykola Ostrovskyy, Ksenia Ostrovska, Lidia Todoriko, Liudmyla Babliuk, et al.
…follow the modified short-term and individualized treatment regimens. Materials and methods: The analysis of 138 inpatient medical records, outpatient health cards and electronic database of the patient register was conducted. Resistant strains of MTB were microbiologically verif…
Natalia Yatskevich, Elmira Gurbanova, Henadz Hurevich, Masoud Dara, Askar Yedilbayev, et al.
<b>Background:</b> Treatment success for patients with rifampicin resistant (RR) TB was only 70% in Belarus in 2017. Modified shorter all-oral treatment regimen was developed by Republican Scientific and Practical Centre on Pulmonology and Phthisiatry of Belarus following WHO rec…
Iryna Makoida, Мykola Ostrovskyy, Ksenia Ostrovska, Л.Д. Тодоріко, Liudmyla Babliuk, et al.
…follow the modified short-term and individualized treatment regimens. PATIENTS AND METHODS: Materials and methods: The analysis of 138 inpatient medical records, outpatient health cards and electronic database of the patient register was conducted. Resistant strains of MTB were m…
Yongli Wei, He Zhang, Maowu Fu, Rui Ma, Ronghui Li, et al.
…e and to provide suggestions regarding dosing and treatment regimens.Patients and Methods: Ten patients with cerebral hemorrhage and pulmonary infection were enrolled in this study. Plasma and sputum samples were obtained at specific time points after the seventh infusion. Linezo…
Borisov Se, Filippov Av, Diana Ivanova, Taisiya Ivanushkina, Н. В. Литвинова, et al.
…study: to determine the efficacy and safety of chemotherapy regimens with bedaquiline in patients with respiratory tuberculosis in the context of everyday clinical practice with minimal non-inclusion criteria. Subjects and methods. In a prospective, open-label, non-randomized, si…
Jinhong He, Xiangxi He, Xiaoxin Xie, Yanhua Fu, Xingxing Luo, et al.
…icacy of DTG+3TC when combined with rifabutin-based anti-TB regimens in patients with TB and HIV.
Marcus A. Horwitz, Daniel L. Clemens, Bai‐Yu Lee
… optimize the in vivo doses of each drug in the most potent regimens. Thus, regimens are identified that are dramatically more effective than the Standard Regimen in treating TB in a mouse model—a model broadly predictive of drug efficacy in humans. The most effective regimens re…
Rodrigo Jon Eva, Rugaiya W Calapis, Edna M. Edrada, Rontgene M Solante
Abstract Background World Health Organization proposed a new drug regimen using BPaLM/BPaL for drug resistant tuberculosis shortening the duration for 6 months and was adopted locally last December 2023. Evidence of its effectivity and treatment outcomes in a developing country w…
Binayak Rimal, Ruth A. Howe, Chandra M. Panthi, Gyanu Lamichhane
…suppression. Current treatments involve prolonged multidrug regimens with poor outcomes and significant side effects, highlighting the urgent need for improved therapies. Using a BALB/c mouse model of chronic M. avium pulmonary disease, we evaluated the efficacy of individual ant…