Showing 126–150 of 200 documents
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Rajesh Kumar Singh, Umesh Kumar
…reactions among childrens with TB undergoing the 9H and 3HP regimens. Methods: This was a prospective, open-label, multicentre randomised trial involving children with newly diagnosed TB. 263 participants were randomised into two groups to have 131 patients in the 3HP group and 1…
Radtke KK, Ernest JP, Zhang N, Ammerman NC, Nuermberger E, et al.
Rifapentine has facilitated treatment shortening for latent tuberculosis infection (LTBI) in combination with isoniazid once weekly for 3 months (3HP) or daily for 1 month (1HP). Our objective was to determine the optimal rifapentine dose for a 6-week monotherapy regimen (6wP) an…
Huaman MA, Sterling TR
…ant component of TB control and elimination. LTBI treatment regimens include once-weekly isoniazid plus rifapentine for 3 months, daily rifampin for 4 months, daily isoniazid plus rifampin for 3-4 months, and daily isoniazid for 6-9 months. Isoniazid monotherapy is efficacious in…
Lai WA, Brethour K, D'Silva O, Chaisson RE, Zwerling AA
…gression to active tuberculosis and like other short-course regimens, has higher treatment completion rates compared to standard regimens such as 9 months of isoniazid. Decision makers would benefit from knowing if the higher up-front costs of rifapentine and of the human resourc…
Chanda Vyawahare, Jyoti Ajagunde, Sahjid Mukhida, Shital Algule
…nd active steps in their management, cost-effective shorter regimens can definitely direct our path towards the goal. Financial support and sponsorship Nil. Conflicts of interest There are no conflicts of interest.
Jung JH, Choi S, Kang Y, Cho DC, Lee SM, et al.
Introduction Tuberculosis (TB) spondylitis, also known as Pott's disease, is a severe form of extrapulmonary TB. Infliximab treatment for Crohn's disease (CD) patients increases the risk of TB, and is likely to increase the risk of TB spondylitis as well. Case presentation We rep…
Kim G, Go U, Park G, Kim Y, Jeong H, et al.
…treatment completion rate of 77.7%. The preferred treatment regimens were 3 months isoniazid + rifampin (3HR) (83.8%), 4 months rifampin (4R) (13.7%), and 9 months isoniazid (2.4%). Completion rates were highest among those on the 4R regimen (87.5%), followed by the 3HR regimen (…
Jeon D
…biomarker for incipient TB. The new shorter rifamycin-based regimens have shown comparable efficacy, but better completion rate and safety compared to the isoniazid-based regimen. In South Korea, LTBI management has been expanded and integrated into key elements of the National T…
…l TB in RD patients with ATB, (8) the recommended treatment regimens and courses for TB in RD patients, (9) the interaction between anti-TB drugs and RD treatment drugs and how to choose alternative regimens, (10) how to handle adverse drug reactions during anti-TB treatment in R…
Kawatsu L, Uchimura K, Ohkado A
Background Screening for latent tuberculosis infection (LTBI) among migrant population has become a critical issue for many low tuberculosis (TB) burden countries. Evidence regarding effectiveness of LTBI programs are limited, however, partly because of paucity of national data o…
Yu Bai, Y. Xue, Mucong Li, Mengtao Li, Chanyuan Wu
…elated immune abnormalities and intensive immunosuppressive regimens.[2] Importantly, these elevated risks persist over time despite improvements in TB control programs, suggesting that advances in public health alone are insufficient to offset disease- and treatment-related susc…
Mingshu Xu, Yue He, Qiao Liu, Qiuping Chen, Zeyu Zhao, et al.
… fully achieve the goal of reducing incidence. All five TPT regimens showed potential to meet the TB elimination targets, with the 3HP regimen (weekly rifapentine + isoniazid for 3 months) performing the best. With the proportion of post-detection consent to TPT of 0.6 and…
Joseph A Kovacs, M.D.
…guidelines and is a part of multiple recommended first-line regimens for the treatment of HIV. However, the use of TAF with rifamycins, including RPT, is not recommended due to potential drug interactions. Thus, the purpose of this study is to determine the effects of concomitant…
Hung-Ling Huang, Meng-Hsuan Cheng, Meng-Rui Lee, Jung-Yien Chien, Po-Liang Lu, et al.
…ns included all World Health Organization (WHO)-recommended regimens. The final regimen was selected through shared decision-making between patients and their COPD physicians, leveraging the long-standing rapport being established. We investigated the prevalence of LTBI in this p…
Stockbridge EL, Loethen AD, Annan E, Miller TL
Background Risk-targeted testing and treatment of latent tuberculosis infection (LTBI) is a critical component of the United States' (US) tuberculosis (TB) elimination strategy, but relatively low treatment completion rates remain a challenge. Both treatment persistence and compl…
Nolt D, Starke JR
…the United States. There are now several effective and safe regimens for the treatment of TBI in children. For improved adherence to therapy, the 3 rifamycin-based regimens are preferred because of their short duration. Daily isoniazid can be used if there is intolerance or drug …
А. G. Samoylova, E. I. Veselova, O. V. Lovаchevа, G Kaminskiy
…y. A large number of drugs used simultaneously in treatment regimens can reduce patient's adherence to treatment, deteriorate drug tolerance and increase the frequency of adverse reactions. Using slow-release drugs within treatment regimens is one of the ways to reduce polypragma…
Alyaquobi FM, Alhakamani F, Alsabari M, Althuhli K, AlMahroqi MA, et al.
Objectives This study aimed to outline the process of implementation of latent tuberculosis (TB) infection (LTBI) screening among migrants using interferon-γ release assay (IGRA), describe the LTBI treatment protocol and cascade of care, and highlight success factors and challeng…
Mohammed A. Agha, Maha Yousif, Walid Shehab-Eldin, NesreenG El-Helbawy, RashaG Moustafa, et al.
…han patients without LTBI. Patients on metformin-containing regimens were only 18% (four of 22 cases) among the LTBI patients, and 89.7% of the whole patients with metformin-containing regimen were without LTBI. Multivariant regression showed that age (odds ratio=1.178, P=0.041) …
Fargher J, Reuter A, Furin J
…B is well tolerated and effective, and several new, shorter regimens - including rfiapenitine-based regimens of 1 month and 12 weeks duration - have been shown to be effective. Not all persons infected with TB go on to develop disease and the risk is the highest in the first 2 ye…
Amber Heyd
BACKGROUND: In Canada, preventive therapy for LTBI has meant long durations and frequent dosing. This contributes to poor adherence and completion rates. In response, a shortened treatment regimen, once weekly rifapentine plus isoniazid for 3 months (3HP), is now available, thoug…
Joseph A Kovacs, M.D.
… cobicistat (DRV/c) comprises part of alternative treatment regimens recommended for the treatment of HIV.2However, drug interactions between these ARV agents and RPT are of concern. Thus, the purpose of this study is to determine the effects of concomitant RPT and INH administra…
Leticia Barton
…entered-to find ways to improve adherence to LTBI treatment regimens. Based on the results of the studies evaluated, directly observed therapy (DOT) showed an increase in adherence to LTBI treatment of approximately 70-80% especially when used in conjunction with other patient-ce…
Lisa Kawatsu, Kazuhiro Uchimura, Akihiro Ohkado
Abstract Background Screening for latent tuberculosis infection (LTBI) among migrant population has become a critical issue for many low TB burden countries. Evidence regarding effectiveness of LTBI programs are limited, however, partly because of paucity of national data on trea…
Yang H, Yang Y, Hu ZD, Xia L, Liu XH, et al.
Three months of weekly rifapentine plus isoniazid (3HP) is a short course regimen for latent tuberculosis infection treatment with satisfied safety and efficacy. However, research on its use in children is limited. In this study, we evaluated the completion rate and safety of the…