Showing 126–150 of 200 documents
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Narayan V, Mohammed N, Savardekar AR, Patra DP, Nanda A
… cervical disease. Combined approaches can be considered in pediatric spinal TB for the correction of kyphotic deformity and its consequent maintenance.
Banik S, Madavi S
…ostoperative rehabilitation. Special considerations such as pediatric Pott's spine and multidrug-resistant tuberculosis are also addressed. The review concludes by summarizing key points, highlighting implications for clinical practice, and providing recommendations for future re…
Hughes JA, Solans BP, Draper HR, Schaaf HS, Winckler JL, et al.
…quantified, and nonlinear mixed-effects modeling performed. Pediatric data were described using a pre-established model of bedaquiline pharmacokinetics in adults. The exposure reference was 187 µg ⋅ h/mL, the median weekly area under the curve (AUC) of adults at week 24 of treatm…
Lingchao Wang, Weiwei Ma, Na Wei, Weijie Guo, Dean Zhao, et al.
…ging integrated nomogram predictive model for DR-TB risk in pediatric patients (≤18 years), and to evaluate the diagnostic performance of the GeneXpert MTB/RIF assay in this context. **METHODS:** This retrospective study included 223 patients with TB aged ≤18 years…
Sheng Ye, Jia Yu, Chenmei Zhang, Shupeng Lin
…d. Key words: Tigecycline; Ventilator-associated pneumonia; Pediatric intensive care unit; Multidrug resistant; Acinetobacter baumanmii
Cesilia C, Tirtosudiro MA, Nataprawira HM
…ur knowledge, this is the first report of BDQ resistance in pediatric.
Ghulam Shabbir Laghari, Zahid Hussain, Lavina Khemani, Syed Zohaib Maroof Hussain, Úzair Yaqoob
…lue=0.03) </ns4:p> <ns4:p> <ns4:bold>Conclusion:</ns4:bold> Pediatric drug-resistant TB is a rising concern. Awareness programs on national and international levels are needed to educate the general population regarding the importance of preventing TB household contact, especiall…
Valentina Aksenova, А. И. Казаков, Н. И. Клевно, А. Д. Пахлавонова, V. A. Romanenko, et al.
…ing performance of the Bedaquiline drug use in treatment of pediatric patients with multidrug-resistant tuberculosis (TB). Materials and methods used: pharmacokinetic (PK) parameters were determined in 10 patients of both genders aged 6 to 17 y/o who had received Bedaquiline drug…
Bangarwa M, Dhingra D, Mittal M, Saigal K, Ghosh A
…ry in the world with almost 27 lakh cases reported in 2019. Pediatric tuberculosis in India accounts for almost 31% of global TB burden. Despite such high mortality and morbidity in children, diagnosis of pulmonary TB in children still remains very challenging. Material and metho…
Ghulam Shabbir Laghari, Zahid Hussain, Lavina Khemani, Syed Zohaib Maroof Hussain, Úzair Yaqoob
…lue=0.03) </ns4:p> <ns4:p> <ns4:bold>Conclusion:</ns4:bold> Pediatric drug-resistant TB is a rising concern. Awareness programs on national and international levels are needed to educate general population regarding the importance of preventing TB household contact, especially am…
Kendra Brett, Camille Dulong, Melissa Severn
…ent regimens may depend on the age of the individual (e.g., pediatric, adult, elderly patients etc.), co-morbidities (e.g., hepatitis, HIV, renal insufficiency), availability of drugs, the ability to adhere to treatment, and whether the TB is drug-susceptible.,There are numerous …
Qutub M, Aldabbagh Y, Govindan P, Alamoudi E
…dominant (59.5%) compared with older population (37.0%) and pediatrics (3.5%), with 55.4% males and 44.6% females, 54.8% of samples were taken from pulmonary and 45.2% from extra pulmonary site of infection. 68.3% and 5.9% of the tuberculosis proven culture were negative by using…
Pal N, Ray R, Kundu S, Hazra A, Sau S, et al.
… of MTB and RRTB were 20.70 % and 20.86 % respectively. The pediatric population had 7.69 % rifampicin resistance, and HIV was strongly associated with the development of TB and RRTB (P < 0.01).
Joy Yong, Ka Lip Chew, Paul Anantharajah Tambyah
… in 24.1% (7/29) of patients. Dosing of clofazimine for the pediatric patients was prescribed at 1–2 mg/kg/day while the adult patients received a range of 50–200 mg/day. Clofazimine was given for a median duration of 148.5 days (range: 14–1212) and most commonly in combination w…
Imperiale BR, Nieves C, Mancino B, Sanjurjo M, Tártara S, et al.
…ethods Children with clinical suspicion of TB attending the pediatric consultation at the Cetrangolo or Cordero Hospitals and adults suspected of MDR-TB and unable to produce sputum attending the Infectious Disease Unit of Cetrangolo Hospital were included in this study. Subjects…
Yu-Jou Lin, Louvina E van der Laan, Mats O Karlsson, Anthony J Garcia-Prats, Anneke C Hesseling, et al.
…WHO) recommended dosing. A reference individual and virtual pediatric population were generated to simulate exposures in adults and children, respectively. Published population models characterizing the exposures of bedaquiline and its metabolite M2, delamanid, and its metabolite…
Prikhodchenko O, Arbuzova Y, Serikbayeva K, Zhakhina G, Rakisheva A, et al.
…nt TB (DR-TB) cases. RESULTS During the study period, 3,317 pediatric TB cases were registered, with 76% being DS-TB and a significant proportion being girls and adolescents over 15 years of age. Our findings show a declining trend in TB notification and prevalence from 2018 to 2…
Garcia-Prats AJ, Draper HR, Finlayson H, Winckler J, Burger A, et al.
Safety concerns persist for long-term pediatric fluoroquinolone use. Seventy children (median age, 2.1 years) treated with levofloxacin 10-20 mg/kg once daily for multidrug-resistant tuberculosis (median observation time, 11.8 months) had few musculoskeletal events, no levofloxac…
Brett K, Dulong C, Severn M
…ent regimens may depend on the age of the individual (e.g., pediatric, adult, elderly patients etc.), co-morbidities (e.g., hepatitis, HIV, renal insufficiency), availability of drugs, the ability to adhere to treatment, and whether the TB is drug-susceptible., There are numerous…
Radtke KK, Hesseling AC, Winckler JL, Draper HR, Solans BP, et al.
…istant tuberculosis (RR-TB) treatment, but there is limited pediatric pharmacokinetic and safety data, especially in young children. We characterize moxifloxacin population pharmacokinetics and QT interval prolongation and evaluate optimal dosing in children with RR-TB. Methods P…
Maja Stošić, Vesna Veković
… implementation of DR TPT. The main challenges were lack of pediatric drug formulations, lack of indications for levofloxacin use for TB and use in this age group.
Phan Tuan Duc, Bui Son Nhat, Le Thi Luyen
In this study, a reasonable population pharmacokinetic model with influencing covariates for pyrazinamide was established based on the data of 129 pulmonary tuberculosis patients in 3 hospitals: Hanoi Lung Hospital, K74 Hospital, and Central Lung Hospital. Blood samples were obta…
Ambreen Ahmad, Islam Gul, Muhammad Idrees, Ansaar Hussain
…arried out from 1st January, 2019 to 31st December, 2019 at Pediatric B Unit,Hayatabad Medical Complex, Peshawar.Materials and Methods: Data was extracted from the database of TBC Center, Hayatabad Medical Complex, Peshawar.It was analyzed with descriptive statistics using SPSS V…
Md Mahbub Ullah, Haris Riaz Khan, Aroosha Imran, Noman Ahmed, Kifayat Ullah, et al.
…tive disease. Evidence synthesis reveals persistent gaps in pediatric, extrapulmonary, and HIV-positive populations, and underscores the need for large-scale validation and equitable deployment. Conclusion: Advanced TB diagnostics offer significant promise but must be strategical…
Tola HH, Khadoura KJ, Jimma W, Nedjat S, Majdzadeh R
…eve the maximum treatment successful. Promoting research on pediatric MDR-TB treatment outcome could also help to fill evidence gap.