Showing 126–150 of 200 documents
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Morey-León G, Mejía-Ponce PM, Granda Pardo JC, Muñoz-Mawyin K, Fernández-Cadena JC, et al.
… MDR-TB and XDR-TB is essential to understand the molecular epidemiology of TB in Ecuador. Importance Tuberculosis, an infectious disease caused by Mycobacterium tuberculosis, most commonly affects the lungs and is often spread through the air when infected people cough, sneeze, …
Said H, Kachingwe E, Gardee Y, Bhyat Z, Ratabane J, et al.
Background Drug-resistant tuberculosis (DR-TB) epidemic is driven mainly by the effect of ongoing transmission. In high-burden settings such as South Africa (SA), considerable demographic and geographic heterogeneity in DR-TB transmission exists. Thus, a better understanding of r…
Utpatel C, Zavaleta M, Rojas-Bolivar D, Mühlbach A, Picoy J, et al.
Background We sought to identify resistance patterns and key drivers of recent multidrug-resistant tuberculosis (MDR-TB) transmission in a TB-prevalent area in Peru. Methods Cross-sectional study including MDR Mycobacterium tuberculosis complex (Mtbc) strains identified in Callao…
Pinhata JMW, Ferrazoli L, Mendes FF, Gonçalves MG, Rabello MCDS, et al.
Purpose To describe katG and inhA mutations, clinical characteristics, treatment outcomes and clustering of drug-resistant tuberculosis (TB) in the State of São Paulo, southeast Brazil. Methods Mycobacterium tuberculosis isolates from patients diagnosed with drug-resistant TB wer…
Diriba G, Alemu A, Tola HH, Yenew B, Amare M, et al.
…tional tuberculosis (TB) control program. Understanding the epidemiology of pre-extensively drug-resistant tuberculosis (pre-XDR-TB) could help clinicians to adapt MDR-TB treatment regimens at an earlier stage. This study aimed to assess second-line anti-TB drug resistance among …
Borham M, Oreiby A, El-Gedawy A, Hegazy Y, Khalifa HO, et al.
…g, detection of mutations, phylogenetic analysis, molecular epidemiology, and interactions occurring within the causative mycobacteria. Consequently, the current review includes consideration of bovine tuberculosis as a disease, conventional and recent diagnostic methods, and the…
Noorizhab MNF, Zainal Abidin N, Teh LK, Tang TH, Onyejepu N, et al.
Multidrug-resistant (MDR) or extensively drug-resistant (XDR) Tuberculosis (TB) is a major challenge to global TB control. Therefore, accurate tracing of in-country MDR-TB transmission are crucial for the development of optimal TB management strategies. This study aimed to invest…
Burhan E, Karyana M, Karuniawati A, Kusmiati T, Wibisono BH, et al.
…ipants globally, further characterization of Indonesia's TB epidemiology in the general population is needed. Strategies, including public policies to optimize case finding, strengthen capacity for resistance testing, and prevent loss to follow-up will be critical to reduce the b…
Shaik J, Pillay M, Moodley J, Jeena P
The objective was to determine the molecular epidemiology and drug susceptibility patterns of Mycobacterium tuberculosis (MTB) of children and their household contacts (HHC) in Umlazi, a high TB-burden township in South Africa. Sixty eight MTBRifPLUS positive TB-infected children…
Dreyer V, Mandal A, Dev P, Merker M, Barilar I, et al.
Background Multidrug-resistant (MDR) Mycobacterium tuberculosis complex (MTBC) strains are a serious health problem in India, also contributing to one-fourth of the global MDR tuberculosis (TB) burden. About 36% of the MDR MTBC strains are reported fluoroquinolone (FQ) resistant …
Zhou Z, Yi H, Zhou Q, Wang L, Zhu Y, et al.
Background Lineage distribution of Mycobacterium tuberculosis (Mtb) isolates is strongly associated with geographically distinct human populations, and its transmission can be further impacted by the bacterial genome. However, the epidemic success of Mtb isolates at an individual…
Wang DM, An Q, Yang Q, Liao Y, Jian Y
Background Osteoarticular tuberculosis (TB) is an uncommon form of extrapulmonary TB. In this study, we analyzed the epidemiological characteristics, common sites, and drug resistance profiles of osteoarticular TB infections occurring in southwest China. Methods A total of 3,254 …
Sousa EO, Carneiro RTO, Montes FCOF, Conceição EC, Bartholomay P, et al.
Background Surveillance of multidrug resistant/extensively drug-resistant tuberculosis (MDR/XDR-TB) is essential to guide disease dissemination control measures. Brazil contributes to a significant fraction of tuberculosis (TB) cases worldwide, but only few reports addressed MDR/…
Liu Y, Posey DL, Yang Q, Weinberg MS, Maloney SA, et al.
…f multidrug-resistant TB (MDR-TB). Objectives: To study the epidemiology of MDR-TB in U.S.-bound immigrants and refugees and to evaluate the effect of culture-based overseas TB screening in U.S.-bound immigrants and refugees on reducing the importation of MDR-TB into the United S…
Natarajan A, Beena PM, Devnikar AV, Mali S
… of Tuberculosis. In this review article history, taxonomy, epidemiology, histology, immunology, pathogenesis and clinical features of both pulmonary tuberculosis (PTB) and extra-pulmonary tuberculosis (EPTB) has been discussed. A great length of detailed information regarding di…
Wu X, Shang Y, Ren W, Wang W, Wang Y, et al.
Objectives We aimed to determine the breakpoint of cycloserine (CS) susceptibility in MGIT and to describe the molecular characteristics of CS-resistant Mycobacterium tuberculosis (MTB) isolates. Methods A total of 124 MTB isolates were recruited in our analysis. Minimum inhibito…
Gomez GB, Siapka M, Conradie F, Ndjeka N, Garfin AMC, et al.
Objectives Patients with highly resistant tuberculosis have few treatment options. Bedaquiline, pretomanid and linezolid regimen (BPaL) is a new regimen shown to have favourable outcomes after six months. We present an economic evaluation of introducing BPaL against the extensive…
Merchant SA, Shaikh MJS, Nadkarni P
Tuberculosis (TB) remains a global threat, with the rise of multiple and extensively drug resistant TB posing additional challenges. The International health community has set various 5-yearly targets for TB elimination: mathematical modelling suggests that a 2050 target is feasi…
Maladan Y, Krismawati H, Wahyuni T, Tanjung R, Awaludin K, et al.
…ing the scientific community in deeply understanding any TB epidemiology and evolution in Papua along with detecting any mutations in genes associated with TB-Drugs. Result A whole-genome sequencing was performed on the random samples from TB Referral Laboratory in Papua utilizin…
Jia H, Xu Y, Sun Z
As the causative bacteria of tuberculosis, Mycobacterium tuberculosis (M. tb ) is aggravated by the emergence of its multidrug-resistant isolates in China. Mutations of six of the most frequently reported resistant genes ( rpoB, katG, inhA, embB, gyrA, and rpsL ) were detected fo…
Khurana P, Saigal K, Ghosh A
…sistance to RIF and INH, helps in understanding the disease epidemiology in various regions. The study was conducted to determine the genetic mutation in drug resistant tuberculosis in children less than 12 years with pulmonary or extrapulmonary tuberculosis. Materials/methods Re…
Sanchini A, Jandrasits C, Tembrockhaus J, Kohl TA, Utpatel C, et al.
IntroductionImproving the surveillance of tuberculosis (TB) is especially important for multidrug-resistant (MDR) and extensively drug-resistant (XDR) TB. The large amount of publicly available whole genome sequencing (WGS) data for TB gives us the chance to re-use data and to pe…
Oudghiri A, Momen G, Aainouss A, Laglaoui A, El Messaoudi MD, et al.
In Morocco, the prevalence of multidrug resistant tuberculosis (MDR-TB) continues to increase especially within previously treated cases; these MDR cases may evolve to extensively drug resistant tuberculosis (XDR-TB) raising major concern to TB control programs. From an epidemiol…
Montiel Quezel-Guerraz N, Sánchez-Porto A, Ortega Torres M, Pérez Santos MJ, Acosta F, et al.
Objectives The aim of this study was to determine resistance to antituberculosis (anti-TB) drugs in Mycobacterium tuberculosis complex isolates from patients diagnosed with Tuberculosis (TB) in southeast Spain and to study related epidemiological factors. Methods This retrospecti…
Mbewana Ntshanka NG, Msagati TAM
… diseases that cause high rates of mortality worldwide. The epidemiology of antibiotic resistance in correlation to people that live with TB and HIV has not been thoroughly investigated particularly in South Africa. Numerous cases of multidrug-resistant TB (MDR-TB) and extensivel…