Showing 126–150 of 200 documents
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Zhou J, Li J, Hu Y, Li S
Background Rifampicin-resistant pulmonary tuberculosis (RR-PTB) presents a significant threat to global public health security. China bears a substantial burden of RR-PTB cases globally, with Guizhou Province experiencing particularly alarming trends, marked by a continual increa…
Warren JL, Grandjean L, Moore DAJ, Lithgow A, Coronel J, et al.
Background Congregate settings may serve as institutional amplifiers of tuberculosis (TB) and multidrug-resistant tuberculosis (MDR-TB). We analyze spatial, epidemiological, and pathogen genetic data prospectively collected from neighborhoods surrounding a prison in Lima, Peru, w…
Venkatesh U, Srivastava DK, Srivastava AK, Tiwari HC
Introduction Multidrug-resistant tuberculosis (MDR-TB) poses a major threat to control of TB worldwide. Adequate information on socioepidemiological factors and their interaction is required for its control. The aim was to study the social and epidemiological profile of MDR-TB pa…
Ismail NA, Ismail F, Joseph L, Govender N, Blows L, et al.
Universal drug susceptibility testing (DST) is an important requirement of the End TB Strategy. The Sensititre broth micro-dilution assay (BMD) tests multiple drugs quantitatively. We defined interpretive criteria for this assay and analysed genotypic-phenotypic relationships. 38…
Li M, Zhang Y, Wu Z, Jiang Y, Sun R, et al.
…ood. We conducted a retrospective, population-based genomic epidemiology study of MDR-TB patients in Shanghai, China, from 2009 to 2018. A genomic cluster was defined as strains with genetic distances ≤ 12 single nucleotide polymorphisms. The transmitted FQ-R was defined as the s…
Zhan Qiu Mao, Huilie Zheng, Hui Qiong Yang, Qian Zhong Liu, Yu Hong Xiong, et al.
…cal similarities to TB. This study elucidates the molecular epidemiology of NTM in Jiangxi (2021–2023). **METHODS:** A retrospective analysis of 20,724 clinical specimens from Jiangxi Chest Hospital was conducted using PCR-reverse blot hybridization assay (PCR-REBA) for N…
Prikhodchenko O, Arbuzova Y, Serikbayeva K, Zhakhina G, Rakisheva A, et al.
… METHODS This study provides a comprehensive analysis of TB epidemiology and treatment outcomes in people under 18 years of age in Kazakhstan between 2018 and 2023, utilising a nationwide database that covers the entire country, with a focus on drug-susceptible (DS-TB) and drug-r…
Merid Y, Hailu E, Habtamu G, Tilahun M, Abebe M, et al.
Introduction Understanding the epidemiology of tuberculosis is limited by lack of genotyping data. We sought to characterize the drug susceptibility testing patterns and genetic diversity of M. tuberculosis isolates in southern Ethiopia. Methodology A cross-sectional study was co…
Boldoo T, Otero L, Uranchimeg B, Purevdagva A, Enebish T, et al.
… routine paper-based surveillance were used to describe the epidemiology of TB in Mongolia; the data included testing presumptive TB cases, TB notifications, drug-resistant cases, treatment outcomes and notifications in prisoners. The proportion of the population tested for TB in…
Mohammadi, A., Nassor, Z.S., Behlim, T., Mohammadi, E., Govindarajan, R., et al.
We conducted an epidemiological and cost analysis for all 13 patients diagnosed with multaidrug-resistant tuberculosis [11 pulmonary, 2 extrapulmonary] in Oman from January 2000 to October 2005. The disease was secondary, or acquired, in 12 of 13 patients. A total of 140 contacts…
Pang Y, An J, Shu W, Huo F, Chu N, et al.
We investigated the epidemiology of extrapulmonary tuberculosis (TB) among patients admitted to Beijing Chest Hospital, Beijing, China, during January 2008-December 2017. Of 19,279 hospitalized TB patients, 33.4% (6,433) had extrapulmonary TB and 66.6% (12,846) had pulmonary TB. …
Hauer B, Kröger S, Haas W, Brodhun B
…countries, including Germany. This movement impacted the TB epidemiology, as Ukraine has a higher prevalence of TB and multidrug-resistant TB rates compared to Germany. Our descriptive analysis of TB surveillance data reveals important information to improve TB care in people dis…
Djika M, Koudokpon CH, Dougnon VT, Sanoussi N, Alphazazi S, et al.
…berculosis remains high. This study aims to investigate the epidemiology of pulmonary tuberculosis at the National Anti-Tuberculosis Center of Niamey in Niger. Methods this study used a quantitative approach with a retrospective and descriptive design. Data were obtained from pos…
Zhenzhen Wang, Liyang Xu, Tengfei Guo, Jinwei Liu, Junrong Jin, et al.
**PURPOSE:** Existing data offer limited guidance on TB control strategies for the non-elderly population, hampering effective epidemic management. This study aimed to analyze TB transmission and molecular resistance profiles among non-elderly patients (<60 years) in Luoyang City…
Ilia Andreevich Bykov
**BACKGROUND:** Russia has the highest prevalence of multidrug-resistant/rifampicin-resistant tuberculosis (MDR/RR-TB) in the world. This study aims to evaluate the impact of sociodemographic determinants on the effectiveness of therapy in patients with MDR/RR-TB in the Khabarovs…
Adegbite BR, Dreyer V, Agbo JBPAA, Mevyann RC, Mfoumbi GARI, et al.
…culosis strains, M. africanum strains also contribute to TB epidemiology in Gabon. The MDR epidemic is mainly driven by one dominant L4 Haarlem outbreak clone that has been spreading for approximately a century in the country.
Ingrid Burkhardt, Nunurai Ruswa, Maria Iitana, Hilya Ekandjo, Mareli M Claassens, et al.
…es was observed over the study period. **CONCLUSION:** The epidemiology and outcome of children with MDR/RR-TB in Namibia are in keeping with the limited international data available; however, the geographical distribution of children with MDR/RR-TB poses a major challenge to th…
Defne Yigci, İlker Kayı, Yusuf Ziya Demiroğlu, Murat Kutlu, Zeki Kılıçaslan, et al.
… health challenge. We provide an overview of the current TB epidemiology in Turkey, highlighting key findings related to TB incidence, diagnostic challenges, and treatment outcomes. **RESULTS:** A gradual decline in TB incidence in Turkiye has been observed over recent year…
Bykov I, Dyachenko O, Ratmanov P, Liu H, Liang L, et al.
Background Growing prevalence of multidrug-resistant/Rifampicin-resistant tuberculosis (MDR/RR-TB; resistance to Isoniazid and Rifampicin/Isolated resistance to Rifampicin) is putting in jeopardy the WHO End TB strategy. This study aimed to identify factors contributing to the hi…
Bei J, Bigi MM, Lima A, Zhang Q, Blanco FC, et al.
Tuberculosis (TB) is an infectious disease, caused by Mycobacterium tuberculosis , primarily affecting the lungs. The M. tuberculosis strain of the Haarlem family named M was responsible for a large multidrug-resistant TB (MDR-TB) outbreak in Buenos Aires. This outbreak started i…
Thinley Dorji, Karchung Tshering, Lila Adhikari, Thinley Jamtsho, Pavitra Bhujel, et al.
**BACKGROUND:** The proportion of multidrug-resistant tuberculosis (MDR-TB) cases is increasing in Bhutan. We conducted the first retrospective genomic-epidemiological study to provide insights into the population structure, resistance patterns, and recent transmission in Bhutan.…
Christina Zouganeli, Dimitra K Toubanaki, Ourania Karaoulani, Georgia Vrioni, Evdokia Karagouni, et al.
: The COVID-19 pandemic has significantly intensified global concerns surrounding antimicrobial resistance (AMR), particularly in relation to tuberculosis (TB). In the European Union (EU), the reallocation of healthcare resources towards managing COVID-19 led to a de-prioritizati…
Nicole Pacchiarini, Felicity Simkin, Mark Postans, George Ahern, Jiao Song, et al.
…illance System and SNP-based data, were merged. Descriptive epidemiology and logistic regression modelling were used to identify factors associated with genotypic clustering. 215 cases were included in the cluster analysis (66% male and 46% born outside of the UK); 115/215 belong…
Weerasuriya CK, Harris RC, McQuaid CF, Bozzani F, Ruan Y, et al.
Background Despite recent advances through the development pipeline, how novel tuberculosis (TB) vaccines might affect rifampicin-resistant and multidrug-resistant tuberculosis (RR/MDR-TB) is unknown. We investigated the epidemiologic impact, cost-effectiveness, and budget impact…
Lugonzo GO, Njeru EM, Songock W, Okumu AA, Ndombi EM
… and treatment efforts. Herein, we determined the molecular epidemiology of drug-resistant TB and associated risk factors in western Kenya. This was a non-experimental, population-based, cross-sectional study conducted between January and August 2018. Morning sputum samples of in…