Showing 126–150 of 200 documents
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Selma Zein Syafira, Nabilla Ghina Zavitri, Su Yan, Yunia Sribudiani, Alexander Lezhava, et al.
…olecular techniques, which detect mutations associated with drug resistance tuberculosis (TB), are promising technologies for rapid diagnosis and monitoring of drug-resistant TB. Pyrosequencing is a potential rapid and robust molecular technique to detect drug resistance but its …
Heather Stone, Mili Duggal, Leonard Sacks, Mayurika Ghosh
Abstract Background Multi and extensively drug-resistant (MDR and XDR) tuberculosis (TB) remains a treatment challenge due to drug adverse events (AEs) and long regimens. Our aim was to identify AEs which resulted from repurposing drugs for MDR and XDR-TB. Methods A PubMed search…
Deelder W, Christakoudi S, Phelan J, Benavente ED, Campino S, et al.
…to existing treatments threatens to derail control efforts. Resistance is mainly conferred by mutations in genes coding for drug targets or converting enzymes, but our knowledge of these mutations is incomplete. Whole genome sequencing (WGS) is an increasingly common approach to …
Barilar I, Fernando T, Utpatel C, Abujate C, Madeira CM, et al.
…d. Detailed molecular data on rifampicin-resistant and multidrug-resistant (MDR) tuberculosis are not available. Here, we aimed at gaining precise data on the determinants of rifampicin-resistant and MDR tuberculosis in Mozambique. Methods In this retrospective observational stud…
Mandira Varma‐Basil, Mridula Bose
…tion assays. However, successful diagnosis and treatment of drug-resistant TB depend on not only rapid identification of MTB complex (MTBC) but also universal access to accurate drug susceptibility testing (DST). Conventionally, the diagnosis of drug resistance in MTB isolates ha…
Tang C, Xu F, Zheng X, Xiang G
…he leading cause of human mortality in infectious diseases. Drug-resistant TB, particularly multidrug-resistant TB and extensively drug-resistant TB, poses a pressing clinical and public health challenge. The main causative agents of TB are known as Mycobacterium tuberculosis (MT…
Köhler N, Karaköse H, Grobbel HP, Hillemann D, Andres S, et al.
The treatment of drug-resistant Mycobacterium tuberculosis relies on complex antibiotic therapy. Inadequate antibiotic exposure can lead to treatment failure, acquired drug resistance, and an increased risk of adverse events. Therapeutic drug monitoring (TDM) can be used to optim…
Eva Sodja, Nataša Toplak, Simon Koren, M. Kovač, Sara Truden, et al.
Drug resistant tuberculosis (TB), especially multidrug (MDR) and extensively drug-resistant (XDR) TB, is still a serious problem in global TB control. Slovenia and North Macedonia are low-incidence countries with TB incidence rates of 5.4 and 10.4 in 2017, respectively. In both c…
Zürcher K, Reichmuth ML, Ballif M, Loiseau C, Borrell S, et al.
Background Drug resistance threatens global tuberculosis control. We aimed to examine mortality in patients with tuberculosis from high-burden countries, according to concordance or discordance of results from drug susceptibility testing done locally and whole-genome sequencing (…
Kardan-Yamchi J, Kazemian H, Haeili M, Harati AA, Amini S, et al.
Objectives Active extrusion of antituberculosis drugs via efflux pumps (EPs) has been suggested as contributing to drug resistance in Mycobacterium tuberculosis. This study was conducted to determine the role of 10 drug efflux transporters in the development of drug resistance in…
Kim S, Seo H, Mahmud HA, Islam MI, Lee BE, et al.
… disease that threatens humanity, and the emergence of multidrug-resistant (MDR), extensively drug-resistant (XDR) strains resistant to drugs suggests that new drug development is urgent. In order to develop new tuberculosis drug, we have conducted in vitro anti-tubercular tests …
Chansuda Wongsrichanalai, Michael E. Kimerling, Jay K. Varma, John R. MacArthur, Jonathan J. Juliano
Drug resistance in malaria and in tuberculosis (TB) are major global health problems. Although the terms multidrug-resistant TB and extensively drug-resistant TB are precisely defined, the term multidrug resistance is often loosely used when discussing malaria. Recent declines in…
Skouras VS, Kalomenidis I
…g categories, detection methods, prevalence and patterns of drug resistance among patients with tuberculous pleural effusion (TPE) and to comment on the management of suspected drug-resistant TPE. Recent findings Pleural and pulmonary tuberculosis (TB) present similar patterns of…
Stone H, Duggal M, Sacks L, Ghosh M
Abstract Background Multi and extensively drug-resistant (MDR and XDR) tuberculosis (TB) remains a treatment challenge due to drug adverse events (AEs) and long regimens. Our aim was to identify AEs which resulted from repurposing drugs for MDR and XDR-TB. Methods A PubMed search…
Pooja Sadana, Vishal Verma, Priyanka Devgun
…g the global TB control. The success rate of treating multi drug resistant remains very low. Method: This cross-sectional study was conducted on all MDR-TB patients who were registered and being treated under PMDT services in Amritsar district from 1st January 2015 to 31st Decemb…
Malik Olatunde Oduoye, Hiba Zafar, Umer Wamiq, Suheera Afzoon, Hafsa Shuja, et al.
…c health concern, particularly due to the emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis. The severity of cough in TB is a critical symptom with the potential for transmission and clinical monitoring. However, the association between gene…
Mvelase NR, Balakrishna Y, Lutchminarain K, Mlisana K
Objectives South Africa ranks among the highest drug-resistant tuberculosis (DR-TB) burdened countries in the world. This study assessed the changes in resistance levels in culture confirmed Mycobacterium tuberculosis (MTB) in the highest burdened province of South Africa during …
Apoorva Narain, Surya Kant, Rikesh K. Dubey, Kanchan Srivastava, Anand Kumar Maurya
…onential increase in tuberculosis (TB) cases, mainly by the drug-resistant (DR) strains of MTB, has created an urgent need for identifying and developing new antituberculosis drugs acting via novel mechanisms. The multi drug-resistant (MDR) TB and extensively drug-resistant (XDR)…
Diksha Zine, Nilma Hirani, Ameeta Joshi
Introduction: Drug-resistant tuberculosis is a major global health issue. Multidrug-resistant TB (MDRTB) and extensively drug-resistant TB (XDR-TB) are particularly concerning. Conventional phenotypic methods being cumbersome and time consuming, molecular assays for the detection…
L.D. Todoriko, V.I. Petrenko, О.С. Шевченко, S.B. Noreіko, Ihor Semianiv, et al.
…t research on molecular genetic aspects of the formation of resistance in tuberculosis patients to avoid it during use of modern treatment programs. Objective — to assess the situation with the evolution of resistance of Mycobacteria tuberculosis and the stages of drug resistance…
Ismail N, Ismail F, Omar SV, Blows L, Gardee Y, et al.
…nization End TB Strategy targets for 2035 are ambitious and drug resistant tuberculosis is an important barrier, particularly in Africa, home to over a billion people. Objective We sought to review the current status of drug resistant tuberculosis in Africa and highlight key area…
Atit Puspitasari Dewi
<b>Background:</b> Drug-resistant tuberculosis (DR-TB) remains a high burden disease in Indonesia with approximately 9038 (1.6%) laboratory-confirmed DR-TB cases found in 2018. Decentralization strategy for DR-TB treatment in primary care apllied in rural area. <b>Objectives:</b>…
Anupa Thampy, Marilyn Mary Ninan, Joy Sarojini Michael, Priscilla Rupali
Abstract Background Treatment of drug-resistant tuberculosis (DR-TB) requires toxic and complex drug regimens. Dismal outcomes occur due to a delay in the report of susceptibility results. WHO endorses genotypic tests like line probe assay (Mtbdrsl) for an early diagnosis enablin…
Schnippel K, Ndjeka N, Maartens G, Meintjes G, Master I, et al.
Background Addition of bedaquiline to treatment for multidrug-resistant tuberculosis was associated with an increased risk of death in a phase 2b clinical trial, resulting in caution from WHO. Following a compassionate access programme and local regulatory approval, the South Afr…
Naoufal Sirri, Christophe Guyeux, Christophe Sola
…is a major public health problem, and the diagnosis of multidrug-resistant and extensively drug-resistant <italic>tuberculosis</italic> is a global health priority. This resistance is mainly caused by mutations in genes coding for drug targets or conversion enzymes, but knowledge…