Showing 126–150 of 200 documents
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А. В. Мишина, V. Yu. Mishin, I. А. Vаsilyevа, Ivan V. Shashenkov
…omated BACTEC MGIT 960 system and with the determination of drug resistance to anti-tuberculosis drugs. Bacteriological, virological, immunological methods and a polymerase chain reaction of diagnostic material from the respiratory tract were used to detect the pathogens of oppor…
SurendraK Sharma
…diagnosis, and often the diagnosis is missed and treated as drug-sensitive or drug-resistant TB. This book is divided into 10 chapters ranging from the taxonomy of the genus Mycobacterium, different molecular tests to identify NTM, susceptibility testing, NTM diseases in humans, …
Vivek Misra, Peeyush Mishra, Dhruvil Mukeshbhai Patel, FNU Yogesh, Nayra Akhter, et al.
…contact (AOR = 2.42; 95% CI = 1.57-5.64). No-smoking and no-drug abuse interaction significantly decreased PTB risk (AOR = 0.34; 95% CI = 0.22-0.51). DISCUSSIONS: This study underscores PTB-ETB distinctions, with PTB linked to social issues, smoking, and TB contact, and reduced b…
Diefenbach-Elstob T, Graves P, Dowi R, Gula B, Plummer D, et al.
…strict, and the need for resources and staff to manage both drug-susceptible and drug-resistant TB cases.
Olga Adriana Căliman-Sturdza
…ith an emphasis on pathophysiology, diagnostics, treatment (drug-susceptible and drug-resistant TBM), and age-specific issues. Xpert MTB/RIF or Xpert Ultra should be the first-line CSF tests in adults and children with suspected TBM; the latter has greater sensitivity in paucibac…
Rong Li, Rong Yin, Yuanming Li, Yaxuan Wei, Bin Zhao, et al.
…effect of the blood-brain barrier against anti-tuberculosis drugs and the issue of drug resistance, treatment outcomes are often suboptimal. Furthermore, current early sensitive diagnostic tools are inadequate, leading to delayed treatment for many patients and adversely affectin…
Fernandová E, Bielaková K, Matějovská-Kubešová H
…f TB in the elderly is challenging because of the increased drug resistance and higher incidence of adverse drug reactions. This article reviews the epidemiology of TB in the CR, immunological aspects, clinical characteristics, diagnosis, management, prevention of TB infection an…
Tamer A. Addissouky
…ulosis treatment shows limited success (60–70%) due to poor drug penetration and emerging resistance. Novel therapeutic approaches, including targeted drug delivery systems, host-directed therapies, and precision medicine based on pharmacogenomics, show promising results in preli…
Barot A, Vora A, Dobariya O, Parikh V, Rahumath S L, et al.
…alyze and compare the clinical and radiological features of drug-sensitive pulmonary TB with DM and without DM. Methodology A comparative, observational study was conducted between August and October 2023. Patients with drug-resistant TB, extrapulmonary TB, those on immunosuppres…
Oo N, Agrawal DK
…nd treatment guidance. Management strategies emphasize multidrug regimens, adjunctive corticosteroids, and emerging therapies like intrathecal administration and nanoparticle-based drug delivery. Host-directed therapies targeting immune modulation and oxidative stress show promis…
Mohammed Qutub, Ghassan Wali, Basem Alraddadi, Nezar Bahabri, Yasser Aldabbagh, et al.
…lmonary and 46.9% from an extrapulmonary. It was noted that resistance to first-line anti-TB drugs individually was found to be 11.0% to Streptomycin, 10.2% to isoniazid, 5.1% to pyrazinamide, 2.4% to Rifampicin, and 1.2% Ethambutol, yet multi-drug resistance (MDR) was found in 2…
Seyedehsara Motamen
…uires early diagnosis, effective chemotherapy regimens, and drug-resistance screening. Therefore, development of shorter and simpler drug regimens that are safe, suitable for joint tuberculosis/HIV treatment, and well tolerated is essential. Fragment-based drug discovery (FBDD) t…
Choe J, Han A, Shin SH, Lee K, Um SW, et al.
…losis and present difficulties in differential diagnosis of drug resistance, new infection, poor patient compliance, and adverse drug reactions. Although diagnosis of mediastinal LNTB has become much easier with the development of endosonography, limited information is available.…
SA Toplu, Üner Kayabaş, Barış Otlu, Yaşar Bayındır, Yasemin Ersoy, et al.
…acillus (AFB), polymerase chain reaction (PCR) positivity, drug resistance, and mortality. Results: The study included 132 patients; 41 (31.1%) were male and 91 (68.9%) were female. The mean age was 46.4±18.5 (17-86) years. Extrapulmonary TB types were TB lymphadenitis in 48 pati…
Priya Das, Asesh Banerjee, Prithviraj Karak
…tremendous public health problem globally. The emergence of drug-resistant bacteria calls for new anti-tuberculous drugs to enhance response to antimicrobial therapy for active TB. However, discoveries of very effective anti-TB new medicines have not materialised yet. Thus, nutri…
Pan Y, Yao Z, Huang L, Xu M, Chen R, et al.
…tment hampered by the side effects of long-term combination drug therapies and the growing issue of drug resistance. Therefore, the development of novel therapeutic strategies is critical. This study focuses on the role of immune checkpoint molecules (ICs) and functions of CD8+ T…
Federico Giannoni, Alessio Lanni, Angelo Iacobino, Lanfranco Fattorini
…ese organisms are difficult to treat due to their intrinsic drug-resistance. In Italy, no major nationwide study on NTM epidemiology and drug susceptibility was performed. METHODS: Data on the epidemiology of 7,469 NTM clinical isolates identified in Italy in 2016-2020 and on the…
Kei Kanata, Shoma Matsushita, Yutaro Ito, Koshiro Ichijo, Masahiro Uehara
…andard treatment with a combination of four antituberculous drugs was started, but drug susceptibility testing revealed resistance to isoniazid, so isoniazid was changed to levofloxacin. After treatment, multiple small nodular shadows in the lung fields disappeared, and the pleur…
Mikashmi Kohli, Leeberk Raja Inbaraj, Angela Salomon, Katie Scandrett, Alexei Korobitsyn, et al.
…ection of Mycobacterium tuberculosis complex and rifampicin resistance in sputum. To extend our previous review on extrapulmonary tuberculosis, we performed this update to inform a WHO policy update. **OBJECTIVES:** To estimate the diagnostic accuracy of LC-aNAATs for extrapulmo…
Rath G, Pradhan D, Ghosh G, Goyal AK
…nti-tubercular treatment and variability in anti-tubercular drug pharmacokinetics are among the major driving factors for the emergence of drug resistance. The rising cases of extrapulmonary TB, cross-resistance patterns, high prevalence of tuberculosis and HIV co-infections make…
Alejandro Hernández-Solís, Maribel Gonzalez‐Villa, José Ernesto Ramírez–González, Yesenia Colín-Muñoz, Raúl Cícero-Sabido
…nse, a rare species in extrapulmonary forms and with a high drug resistance index.
Anushka Soni, Richa Mishra, Alok Nath, Prerna Kapoor
…ground Accurate and timely detection of(MTB) and associated drug resistance is vital for effective tuberculosis (TB) control, especially in high-burden countries like India. In recent years, molecular assays have significantly improved TB diagnostics. This study evaluates and com…
Nair A, Greeny A, Nandan A, Sah RK, Jose A, et al.
…several limitations, including extended treatment duration, drug resistance, patient noncompliance, poor bioavailability, and suboptimal targeting. Advanced drug delivery strategies have emerged as a promising approach to address these challenges. They have the potential to enhan…
Ramanath Mahale, Diksha Shirodkar, Jumail Khader, H. K. Mithun, Amanullah M. Bappanad
… appropriate anti-tubercular treatment (ATT) for non-severe drug-susceptible TB. The second case describes a 5-year-old girl who developed TB during immunosuppressive treatment for nephrotic syndrome. Her condition progressed to severe extra-PTB as grade 3 tubercular meningitis w…
Victor Abiola Adepoju, Safayet Jamil, Ify Genevieve Ifeanyi‐Ukaegbu, Olusola Daniel Sokoya, ABM Alauddin Chowdhury, et al.
…e joint (2.9%). All cases diagnosed during this period were drug-sensitive TB, with no cases of drug-resistant TB reported. (Data available for 2021–2023): X-ray was the most used diagnostic tool, accounting for 76% of diagnoses, followed by GeneXpert (14%) and multiple diagnosti…