Showing 126–150 of 200 documents
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Tan Kah Shien, Mas Fazlin Mohamad Jailaini, Azat Azrai Azmel, Vijayan Munusamy, Arvindran Alaga, et al.
**BACKGROUND:** Tuberculous pleural effusion (TPE) remains a diagnostic challenge, particularly in tuberculosis-endemic regions. Pleural fluid adenosine deaminase (pfADA) is widely used as a diagnostic biomarker; however, its optimal cutoff value may vary depending on the epidemi…
Fahriye Hakan-Groen
The Dutch national uveitis guideline advises on the diagnostic work-up of uveitis patients. However, some of the included diagnostic tests as well as their value in the work-up for new uveitis patients were so far not systematically studied. \nWith the rise of novel diagnost…
Yifan Tang, Cheng Chen, Mingming Chen, Kai Wang, Sifan Wang, et al.
**BACKGROUND:** Tuberculosis (TB) remains a major public health concern. Despite improved diagnostic tools, delays in TB diagnosis persist and hinder control efforts. **OBJECTIVE:** This study aims to investigate the spatiotemporal patterns of TB diagnostic delay and identify in…
Zou X, Xu H, Hu Q, Qi Q, Ma X, et al.
Background Microbiological diagnosis of pulmonary tuberculosis (PTB) is hampered by a low pathogen burden, low compliance and unreliable sputum sampling. Although endobronchial ultrasound-guided transbronchoscopic lung biopsy (EBUS-TBLB) has been found to be useful for the assess…
Zhang M, Li D, Hu ZD, Huang YL
Tuberculosis pleural effusion (TPE) is common in clinical practice, and its diagnosis remains a challenge for clinicians. Ziehl-Neelsen staining, PE Mycobacterium tuberculosis culture, and biopsy are the gold standards for TPE diagnosis; however, they are time-consuming, invasive…
Tennis Tomo Camagu Potelwa
In the HIV/TB endemic public care setting of the Western Cape, diagnostic consideration of patients with persistent lymphadenopathy is focused towards extra- pulmonary tuberculosis (EPTB), more than other infectious or malignant causes of lymphadenopathy. We investigated patients…
Peng L, Ma W, Zhong L, Yang J, Wu H, et al.
The aim of this study was to evaluate the diagnostic accuracy of the IGRA, TST, and TBST by combining diagnostic test accuracy (DTA) analysis and network meta-analysis (NMA) to increase the reliability and accuracy of diagnostic methods and promote the eradication of TB. An elect…
Niti Sureka, Smriti Sharan, Charanjeet Ahluwalia, Sana Ahuja, Sunil Ranga
**BACKGROUND:** Pulmonary diseases represent a significant global health challenge, underscoring the need for accurate diagnostic methods to ensure effective management. Bronchoalveolar lavage (BAL) is an essential diagnostic tool, providing valuable insights into various lung co…
Cristina Blanco‐Vázquez, Marta Alonso‐Hearn, Ramón A. Juste, María Canive, Tania Iglesias, et al.
Bovine paratuberculosis (PTB) is a chronic granulomatous enteritis, caused by Mycobacterium avium subsp. paratuberculosis (MAP), responsible for important economic losses in the dairy industry. Current diagnostic methods have low sensitivities for detection of latent forms of MAP…
Vijay Pratap, Astha Lalwani, Ankur Malhotra
…synechiae were seen in 46% and 18%, respectively. Molecular diagnostics GeneXpert and tuberculosis-polymerase chain reaction (TB-PCR) showed high sensitivity (up to 100%) and varied specificity (33% to 100%). The prevalence of FGTB ranged from 6.73% to 45%, with conception rates …
Kay A, Vasiliu A, Carratala-Castro L, Mtafya B, Mendez Reyes JE, et al.
…Reliance on sputum as the primary specimen for tuberculosis diagnostics contributes to this diagnostic gap. We evaluated the diagnostic accuracy and additive yield of a novel stool quantitative PCR (qPCR) assay for the diagnosis of tuberculosis in three countries in Africa with h…
Joyce Mulenga, Lonia Mwape, Patricia Katowa-Mukwato
Background Tuberculosis (TB) and human immunodeficiency virus (HIV) constitute the main burden of infectious disease in resource-limited Countries6. Persons infected with HIV are particularly susceptible to tuberculosis, both from the reactivation of latent infection and from new…
Srivastava S, Singh PK, Vatsalya V, Karch RC
Objectives Diagnostics is the first step for the treatment and eradication of infectious microbial diseases. Due to ever evolving pathogens and emerging new diseases, there is an urgent need to identify suitable diagnostic techniques for better management of each disease. The suc…
Miller AC, Arakkal AT, Koeneman SH, Cavanaugh JE, Polgreen PM
Objectives A first step in studying diagnostic delays is to select the signs, symptoms and alternative diseases that represent missed diagnostic opportunities. Because this step is labor intensive requiring exhaustive literature reviews, we developed machine learning approaches t…
Bermawi B, Kurniasari DW, Imaniar A, Hidayatih N, Lisnawati DA, et al.
Introduction Tuberculosis (TB) is a serious global health problem in Indonesia, which is the country with the secondhighest TB burden after India. Accuracy in TB diagnosis is the key to effective treatment and decreased transmission rate. One of the latest diagnostic methods is i…
Ntinginya NE, Kuchaka D, Orina F, Mwebaza I, Liyoyo A, et al.
…portunities to maximise uptake and utilisation of molecular diagnostics in routine healthcare settings. Methods Using the implementation of WHO approved TB diagnostics, Xpert Mycobacterium tuberculosis /rifampicin (MTB/RIF) and Line Probe Assay (LPA) as a benchmark, we evaluated …
Barış Çil, Mehmet Sinan Bodur, Mehmet Kabak
**BACKGROUND:** The diagnosis of extrapulmonary tuberculosis (EPTB) often depends on advanced imaging, invasive tissue sampling, and multidisciplinary referral pathways. These complex, procedure-dependent diagnostic processes are particularly vulnerable to disruption during perio…
Dionysius B. P. Manyakori, Andri Danika
Abstract Wrist tuberculosis (TB) is a rare manifestation of osteoarticular TB that presents substantial diagnostic challenges, particularly in TB-endemic regions. Its insidious onset and nonspecific clinical manifestations frequently lead to misdiagnosis and delayed treatment. Th…
Suneja M, Beekmann SE, Dhaliwal G, Miller AC, Polgreen PM
Objectives Diagnostic delays are a major source of morbidity and mortality. Despite the adverse outcomes associated with diagnostic delays, few studies have examined the incidence and factors that influence diagnostic delays for different infectious diseases. The objective of thi…
He Y, Zhu Z, Chen Y, Chen F, Wang Y, et al.
Objectives Differentiating Crohn's disease (CD) from intestinal tuberculosis (ITB) remains a diagnostic challenge. Misdiagnosis carries potential grave implications. We aimed to develop and validate a novel diagnostic nomogram for differentiating them. Methods In total, 310 eligi…
Liu XT, Dong XL, Zhang Y, Fang P, Shi HY, et al.
Background Pleural effusions occur for various reasons, and their diagnosis remains challenging despite the availability of different diagnostic modalities. Medical thoracoscopy (MT) can be used for both diagnostic and therapeutic purposes, especially in patients with undiagnosed…
Wang B, Wang Q, Li M, Yu J, Jiang F, et al.
…t yet discussed in current literature as a means for TB-IAI diagnostics. Here we describe a cohort of patients with TB-IAI diagnosed by mNGS show high efficiency of mNGS for detection of this pathology and present a clinical algorithm supplementing conventional methods for TB-IAI…
Seki M, Kim CK, Hayakawa S, Mitarai S
…iagnostic methodologies for TB, and the impact of those new diagnostics on TB control in such situations. Moreover, the perspective of TB management based on laboratory examinations is described. Smear microscopy with sputum samples is the only laboratory examination available in…
Gustavo Tapia-Sequeiros, Miguel Hueda-Zavaleta, Juan Carlos Gómez de la Torre, Arantsa Hernandez-Vargas, Claudia Barletta-Carrillo, et al.
**BACKGROUND:** Motivation for the study. Peru has a high prevalence of tuberculosis, therefore, it is necessary to use diagnostic methods with high sensitivity and specificity to adequately identify cases and provide timely treatment. Main findings. Our results indicate that, wh…
Assebe LF, Erena AK, Fikadu L, Alemu B, Baruda YS, et al.
…ational TB guideline recommends the primary use of rapid TB diagnostics whenever feasible, there is limited evidence available that assess the efficiency of deploying various diagnostic tools in the country. Hence, this study aims to evaluate the cost-effectiveness of rapid TB/MD…