Showing 126–150 of 200 documents
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Ifedayo MO Adetifa, MD FWACP, Martin OC Ota, MD FWACP PhD
In populations with high prevalence of latent tuberculosis infection (LTBI), malnutrition (PEM) may influence incident rates of TB. PEM and specific micronutrient deficiencies compromise cell mediated immunity (CMI) and increase susceptibility to, or severity of infections. Vitam…
Purba BB, Sembiring RJS, Sitorus FE, Fahdi F, Purba D
…ound Indonesia reported the second-highest global burden of tuberculosis after India, with a 2.6% increase in cases from the previous year. Objective This study aimed to evaluate case-finding of latent tuberculosis infection (LTBI) and differences in tuberculin induration diamete…
I. V. Kudryavtsev, Анна Старшинова, Artem Rubinstein, Anastasia Kulpina, Hong Ling, et al.
Despite advancements in modern medicine, tuberculosis continues to be one of the leading causes of death globally. Findings indicate that COVID-19 may trigger the activation of tuberculosis infection (TB), leading to its spread. Despite the development of new immunological diagno…
Navin Kumar Devaraj, Rabiatul Adawiyah Sufian, Nuzul Evana Jasmi, Ah San Leong, Rosmaliza Kamaruddin, et al.
INTRODUCTION: Latent tuberculosis infection (LTBI) is defined as the presence of Mycobacterium tuberculosis antigen without the evidence of tuberculosis infection. Approximately 5-10% of untreated LTBI would progress to clinically active tuberculosis during their lifetime or usua…
Kulkanya Chokephaibulkit, Keswadee Lapphra, Paninun Srinuchasart, Sansnee Senawong, Utane Rungpanich, et al.
…ldren younger than 5 years who were recently diagnosed with tuberculosis or had recent exposure to active tuberculosis. QuantiFERON-TB Gold, T-SPOT.TB and tuberculin skin test were performed in each patient.Results: Of the 60 children, median age 3.3 years, 17 had tuberculosis an…
Qi X, Yang Q, Cai J, Wu J, Gao Y, et al.
Household contacts (HHCs) of patients with active tuberculosis (ATB) are at higher risk of Mycobacterium tuberculosis ( M. tuberculosis ) infection. However, the immune factors responsible for different defense responses in HHCs are unknown. Hence, we aimed to evaluate transcript…
Lijiao Chen, Lingke Yuan, Tingting Sun, Ruiqing Liu, Qing Huang, et al.
Abstract Background Tuberculosis is a chronic infectious disease caused by mycobacterium tuberculosis (MTB) and is the ninth leading cause of death worldwide. It is still difficult to distinguish active TB from latent TB ,so it is very important for individualized management and …
Giovanni Battista Migliori, Ong C, Linda Petrone, Lia D’Ambrosio, Rosella Centis, et al.
Latent tuberculosis infection was the term traditionally used to indicate tuberculosis (TB) infection. This term was used to define “a state of persistent immune response to stimulation by Mycobacterium tuberculosis antigens through tests such as the tuberculin skin test (TST) or…
Alison Smith, Russell R. Kempker, Liya Wassie, Kidist Bobosha, Azhar Nizam, et al.
…amines the association between diabetes mellitus and latent tuberculosis infection among a cohort of household contacts exposed to active tuberculosis in Ethiopia, focusing attention on the need for further translational research to determine the mechanisms of susceptibility to M…
Owusu W, van Vliet AHM, Riddell NE, Stewart G, Akwani WC, et al.
In low-resource settings with high tuberculosis (TB) burdens, lack of rapid diagnostic methods for detection and differentiation of Mycobacterium tuberculosis complex (MTBC) is a major challenge affecting TB management. This study utilized comparative genomic analyses of MTBC lin…
E. M. Bogorodskaya, В. И. Литвинов
…erature review briefly describes the main aspects of latent tuberculosis infection and the place of tuberculosis infection among various variants of the course of tuberculosis. Latent tuberculosis infection is one of the main problems of phthisiology. Today we have made significa…
Bo Su, Yong Fang, Na Wang, Liang Tang, Xiaojun Yang, et al.
…onsuming and of low sensitivity for the diagnosis of active tuberculosis (ATB). The purpose of this study is to investigate the accuracy of CD27 - CD38 + IFN-γ + CD4 + /CD4 + for active tuberculosis (ATB) diagnosis. Methods: This prospective diagnostic accuracy study was conducte…
Yong Fang, Na Wang, Liang Tang, Xiaojun Yang, Yuan Tang, et al.
…onsuming and of low sensitivity for the diagnosis of active tuberculosis (ATB). The purpose of this study is to investigate the accuracy of CD27 - CD38 + IFN-γ + CD4 + /CD4 + for active tuberculosis (ATB) diagnosis. Methods: This prospective diagnostic accuracy study was conducte…
Chen L, Yuan L, Sun T, Liu R, Huang Q, et al.
Background Tuberculosis is a chronic infectious disease caused by mycobacterium tuberculosis (MTB) and is the ninth leading cause of death worldwide. It is still difficult to distinguish active TB from latent TB,but it is very important for individualized management and treatment…
Mariana S. Sousa, Inês Ladeira, Carlos Fernandes, Ana Ponte, Adélia Rodrigues, et al.
Portugal is one of the countries with the highest tuberculosis burden in the European Union, with a reporting rate in the North region registered in 2016 of 21.6 cases per 100000 inhabitants. Anti-TNF can increase up to five times the reactivation of tuberculosis in patients with…
Muhammad Irshad, Shahzeen Irshad
…vity (83%) and 100% specificity for detecting Mycobacterium tuberculosis from fresh ulcer base biopsy samples, offering an alternative to conventional methods like acid-fast bacillus staining, TB-PCR, and histopathological examination. Given the diagnostic challenges in tuberculo…
I. Mouslim, Chaimae Jioua, Abdelfettah Touibi, S. Ouahid, F. Nejjari, et al.
…apy between 2021 and 2024. Results The prevalence of latent tuberculosis TBL identified in patients with chronic inflammatory bowel disease candidates for anti-TNFα therapy in our study was 24.1%, detected by the Quantiferon Gold IT® test. Factors influencing the results of the t…
Flynn AG, Aiona K, Haas MK, Reves R, Belknap R
Although rare, subclinical tuberculosis disease can be missed during evaluations for latent tuberculosis infection, and can manifest with symptoms during latent tuberculosis treatment. Among over 8000 patients treated for latent tuberculosis we found no evidence of acquired drug …
Derliyana Irwan Badarudin, Muhammad Nasrum Massi, Ahyar, Arif Santoso, Burhanuddin Bahar, et al.
…Immunosorbent Assay (ELISA). The samples in this study were tuberculosis and latent after 2 months of treatment, the samples used were 30 samples, statistic tests were normality tests with Shapiro Wilk and Independent sample tests. The results of the research that has been done, …
Barbara E de Bary, Marlies Heudobler, Alois Fürst, Kirsten Utpatel, Elisabeth Schuierer, et al.
**INTRODUCTION:** Tuberculosis (TB) remains a significant global health issue, with extrapulmonary manifestations accounting for a notable proportion of cases. Perianal tuberculosis, however, is a rare presentation of TB, often leading to delayed diagnosis due to its nonspecific …
Y. Nakano, Kenta Yamada, Koji Suzuki, Motoko Yasutomi, Motohiro Takeuchi, et al.
Pancreatic tuberculosis (TB) is a rare form of extrapulmonary TB.1 We present a case of pancreatic TB requiring differentiation from pancreatic neoplasms. A 13-year-old boy born in the Philippines presented with fever and back pain lasting 6 days. While living in the Philippines,…
Carvalho I, Goletti D, Manga S, Silva DR, Manissero D, et al.
Tuberculosis (TB) is a major cause of childhood morbidity and mortality worldwide. The aim of this review is to describe the management of the child with TB and latent tuberculosis infection (LTBI). To develop this article, a working group reviewed relevant epidemiological and ot…
Lu P, Xu J, Wang R, Gong X, Liu Q, et al.
… is recommended by the World Health Organization for latent tuberculosis infection (LTBI). However, it is still unknown how the EC skin test performs in students during a school tuberculosis outbreak. Methods We conducted an epidemiological investigation to assess the performance…
Ye L, Cao Y, Fu Y, Tian C, Cao Q
Background Discriminating Crohn's disease (CD) with latent tuberculosis infection (LTBI) from intestinal tuberculosis (ITB) in tuberculosis-endemic regions remains challenging. Aim To assess whether targeted next-generation sequencing (tNGS) could be an efficient method for ITB d…
Della Bella C, Spinicci M, Grassi A, Bartalesi F, Benagiano M, et al.
Background Tuberculosis (TB) still is a major worldwide health problem, with 10.4 million new cases in 2016. Only 5-15% of people infected with M. tuberculosis develop TB disease while others remain latently infected (LTBI) during their lifetime. Thus, the absence of tests able t…