Showing 101–125 of 200 documents
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Mokry J, Porvaznik I, Kusnir P, Dohal M, Solovic I
The incidence of tuberculosis (TB) in some countries increases continuously, especially caused by mycobacterial strains resistant to various anti-tuberculotic drugs (AT). The emergence and spread of drug-resistant tuberculosis (multidrug-resistant - MDR-TB, and extensively drug-r…
Pratik Kumar, Amardeepak Toppo, Roshan Lal, Sagarika Pradhan, Puneet Bhardwaj
…nd: There is an increasing incidence of multidrug-resistant tuberculosis (TB)/preextensively drug-resistant TB (XDR TB) and XDR TB globally. Therefore, rapid diagnostic tests with good sensitivity and specificity are need of hour. Truenat Mycobacterium tuberculosis (MTB) is one s…
World Health Organization. Regional Office for Europe
… to the burden of multidrug- and extensively drug-resistant tuberculosis (M/XDR-TB), all 53 Member States in the WHO European Region endorsed the Consolidated Action Plan to Prevent and Combat Multidrug- and Extensively Drug-resistant Tuberculosis in the WHO European Region 2011–…
Burhan E, Karyana M, Karuniawati A, Kusmiati T, Wibisono BH, et al.
…are lower than global testing rates per the 2020 WHO global tuberculosis (TB) report, prevalence of multidrug-resistant TB may be underestimated. Our study aimed to evaluate prevalence and patterns of TB drug resistance (DR) within Indonesia. We conducted a cross-sectional analys…
Thanaphon Yisankhun, Saran Sujinpram, Phimruethai Chongkratok, Sattawat Sanmai, Vatcharapong Sungketkit, et al.
… hospital was confirmed with pre-extensively drug-resistant tuberculosis (pre-XDR-TB) after a delay of over 30 days following an abnormal chest X-ray (CXR). We investigated to verify the outbreak and diagnosis, describe its characteristics, review the HCW TB screening program, an…
Dr Hariharan
Background: Tuberculosis (TB) is a chronic infectious disease that has afflicted mankind for 5000 years. It has caused more deaths in adults than any other infectious disease The emergence of multidrug-resistant (MDR) TB has introduced challenging, but surmountable, complexities …
Osei-Wusu S, Amo Omari M, Asante-Poku A, Darko Otchere I, Asare P, et al.
Background Drug resistance surveillance is crucial for tuberculosis (TB) control. Therefore, our goal was to determine the prevalence of second-line anti-TB drug resistance among diverse primary drug-resistant Mycobacterium tuberculosis complex (MTBC) isolates in Ghana. Materials…
Ncha R, Variava E, Otwombe K, Kawonga M, Martinson NA
…s predictive of TTSCC in patients with multi-drug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) in the North-West Province. Methods A retrospective cohort study, abstracting patient demographic and clinical data, laboratory results, dates of…
Basingnaa A, Antwi-Baffour S, Nkansah DO, Afutu E, Owusu E
The emergence of multidrug-resistant tuberculosis (MDR⁻TB) and more recently, extensively drug-resistant (XDR) TB has intensified the need for studies aimed at identifying factors associated with TB drug resistance. This study determined the differences in plasma concentrations o…
Renuka Murhar, Sunita Gajbhiye, S.S. Zodpey, Shailesh Lichade
…lones indicating pre-XDR TB. Conclusions: For Mycobacterium tuberculosis detection in extrapulmonary samples, multiple modalities should be employed so that the bacilli in these samples is not missed and the turn-around time is lowered which is a key to TB control strategy.
Dmytro Butov, Tetiana Butova, N. A. Rudova, Nadiya Sapelnik, Olena Borysova, et al.
… the treatment outcome of patients with multidrug-resistant tuberculosis (TB) and Beijing lineage 2 (BL2) of MTB. <b>Methods:</b> This is a prospective, cohort study of all patients with culture-confirmed pulmonary TB and MTB resistance to at least isoniazid and rifampicin. Bacte…
Supriya Dhakne
Introduction: Multidrug‑resistant tuberculosis (MDR‑TB) has created a significant health problem in most of the countries, and it is an obstacle to effective TB control. Aims and Objectives: The study aims to study the prevalence of MDR‑TB among new cases, retreatment cases and t…
Shaik J, Pillay M, Moodley J, Jeena P
…demiology and drug susceptibility patterns of Mycobacterium tuberculosis (MTB) of children and their household contacts (HHC) in Umlazi, a high TB-burden township in South Africa. Sixty eight MTBRifPLUS positive TB-infected children (TIC) (≤14 years) and 111 HHC were enrolled. Dr…
Xi-Ling Huang, Aliaksandr Skrahin, Pu-Xuan Lu, Sofia Alexandru, Valeriu Crudu, et al.
Abstract Multidrug-resistant tuberculosis (mdrtb) refers to TB infection resistant to at least two most powerful anti-TB drugs, isoniazid and rifampincin. It has been estimated that globally 3.5% (which can be much higher in some regions) of newly diagnosed TB patients, and 20.5%…
Pooja Sadana, Vishal Verma, Priyanka Devgun
…reatment outcome. Other factors like sex, residence, typeof tuberculosis and the HIV status of the patient did not affect the treatment outcome.
Benremila D, Djoudi F, Gharout-Sait A, Kheloufi S, Spitaleri A, et al.
…un on the Illumina NextSeq500 System. Among 82 isolates, 21 tuberculosis (TB) isolates (25.6%) were drug resistant, including 10 MDR and 4 pre-extensively drug-resistant (XDR)-TB. The mutation Ser315Thr in the kat G gene was confirmed in 15 isolates. In rpo B, Ser450Leu and His44…
Pooja Sadana, Vishal Verma, Priyanka Devgun
…eatment outcome. Other factors like sex, residence, type of tuberculosis and the HIV status of the patient did not affect the treatment outcome.
Argita D. Salindri, Maia Kipiani, Nino Lomtadze, Nestani Tukvadze, Zaza Avaliani, et al.
…e relationship between common comorbidities in persons with tuberculosis (TB) (including human immunodeficiency virus [HIV], diabetes, and hepatitis C virus [HCV]) with post-TB mortality. We conducted a retrospective cohort study among persons who initiated treatment for rifampic…
Ketema T, Tadesse M, Bonsa Z, Balay G, Kebede W, et al.
…f drug resistance, including resistance to second-line anti-tuberculosis (TB) drugs, is crucial for the effective control and management of pre-extensively drug-resistant TB (pre-XDR-TB) and extensively drug-resistant TB (XDR-TB). The Xpert MTB/XDR assay is the WHO recommended me…
Meskini M, Zamani MS, Amanzadeh A, Bouzari S, Karimipoor M, et al.
…d-dendritic cells (mo-DCs) in connection with Mycobacterium tuberculosis (MTB) infection, with particular emphasis on pro/ anti-inflammatory genes. Methods In the context of this investigation, mo-DCs were infected by various active strains of MTB (Rifampicin-resistant [RIFR], H3…
Human Sciences Research Council
…'s population of the human immunodeficiency virus (HIV) and tuberculosis (TB) co-infected individuals. It has been estimated that approximately 60% of people with TB are co-infected with HIV (WHO 2012). Co-infected individuals have almost double the chances of getting multi-drug …
Girase R, Ahmad I, Patel H
…st 35 years. It exhibits bacteriostatic efficacy against M. tuberculosis and is a crucial constituent of the BPaL regimen (Bedaquiline, Pretomanid, and Linezolid), which was authorized by the FDA in 2019 for the treatment of XDR-TB or MDR-TB. Despite its unique mechanism of actio…
Buziashvili M, Davtyan H, Sereda Y, Denisiuk O, Gozalov O, et al.
Considering the complexity of second-line anti-tuberculosis (TB) treatment regimens, the management of drug-resistant TB (DR-TB) in Georgia remains a major challenge. Since the introduction of new and repurposed anti-TB medications, the implementation of active TB Drug Safety Mon…
Manisha Nagpal, Sarthak Chawla, Priyanka Devgun, Naresh Chawla
Background: Multidrug resistant tuberculosis (MDR-TB) has become a major public health problem. It is associated with significant morbidity and mortality. The treatment success rate worldwide is around 50%.Methods: This cross-sectional study was conducted on all MDR-TB patients w…
World Health Organization. Regional Office for Europe
…arming problem of multidrug- and extensively drug-resistant tuberculosis (M/XDR-TB) in the WHO European Region, and in order to scale up a comprehensive response and to prevent and control M/XDR-TB, a consolidated action plan has been developed for 2011–2015 for all 53 Member Sta…