Showing 101–125 of 172 documents
Sorted by hybrid relevance (keyword + semantic via RRF)
Sofia Kostoudi, Robert Hammond
… or treatment), pediatric TB, cancer and dialysis patients, pregnancy, IV drug users, animal models, papers published before 2005, co-infected patients, IBD and transplant patients, and finally secondary literature. Such criteria were incorporated due to the differences in TB imm…
Xiaohong Li, Jiahui Qiu, Yuanji Ma, Tao Cui
… made it possible for women with latent TB to conceive. The pregnancy leads to an increased incidence of reactivation of latent TB. TB related maternal and neonatal complications has increased in recent years after IVF-ET. Chest X-ray is a routine screening procedure for active T…
Diogo Canhoto, Barbara Nascimento, António Jorge Ferreira, Paulo Cravo Roxo
…n 2019 (n=113) and 2020 (n=82). Exclusion criteria included pregnancy, immunosuppression, SARS-CoV-2 vaccination, and prior mycobacterial infection or COVID-19. Screening was performed by tuberculin skin test (TST) (2 IU) and a diagnosis of LT was made for patients with positive …
S. V. Smerdin, M.A. Plekhanovа, А. A. Yakovleva, N. N. Shishilyakina, S. V. Gorlova
The article presents a clinical case of generalized tuberculosis in a woman with multiple pregnancies after in vitro fertilization, which indicates the continuing problem of early detection of tuberculosis and timely implementation of preventive and therapeutic measures. Lack of …
ГБУЗ Московской области «Московский областной клинический противотуберкулезный диспансер», С. В. Смердин, M.A. Plekhanovа, А. A. Yakovleva, N. N. Shishilyakina, et al.
The article presents a clinical case of generalized tuberculosis in a woman with multiple pregnancies after in vitro fertilization, which indicates the continuing problem of early detection of tuberculosis and timely implementation of preventive and therapeutic measures. Lack of …
Javier P Gisbert, María Chaparro
…t on cardiovascular risk, but monitoring is advised. Use in pregnancy is discouraged due to potential risks, and breastfeeding is contraindicated because of drug excretion in milk.
Jyoti S. Mathad, MD, MSc
The purpose of this study was to evaluate the pharmacokinetics (PK), tolerability, and safety of once-weekly doses of rifapentine (RPT) and isoniazid (INH) in HIV-1-infected and HIV-1-uninfected pregnant and postpartum women with latent tuberculosis (TB). TB is a major cause of …
Dereck Tait, MD, Angelique Luabeya, MD
This is a Phase I/IIa, double-blind, randomized, placebo-controlled, dose- and regimen-finding study in healthy adults with and without LTBI, who are BCG-vaccinated, HIV negative, and have no history or evidence of TB disease. The investigational product is AERAS-456 at 3 dose le…
Angelique Luabeya, MD
This is a Phase I, open-label, dose-escalation study with three study groups. This study will be conducted in 25 HIV negative subjects, 17 of whom will have Latent Tuberculosis Infection (LTBI) and 8 of whom will not have LTBI at study enrollment. The investigational product is A…
Angelique Luabeya, MD
MTBVAC at four dose levels: 5 x 10\^3 CFU, 5 x 10\^4 CFU, 5 x 10\^5 CFU, and 5 x 10\^6 CFU. The active control is BCG (5 x 10\^5 CFU). Participants will receive a single dose of MTBVAC or BCG revaccination administered intradermally on Study Day 0. This is a Phase 1b/2a, double-…
Adrian Martineau, PhD
Mycobacterium tuberculosis (Mtb) is a major human pathogen, responsible for an estimated 10.6 million cases of active tuberculosis (TB) and 1.6 million deaths in 2021. Most adult cases of active TB arise from progression of latent tuberculosis infection (LTBI), whose global preva…
Aleksey V. Kazakov, MD, Anastasia G. Samoylova, MD, Valentina A. Aksyonova, Prof.
The aim of this study is to test the recombinant tuberculosis skin test in the previously BCG vaccinated healthy adults with low risk of TB development, to determine the test specificity. Recombinant tuberculosis allergen (RTA) is a recombinant fusion protein CFP10-ESAT6 produce…
Jirge PR, Chougule SM, Keni A, Kumar S, Modi D
Study question What is the effect of latent genital tuberculosis (GTB) on ovarian reserve in infertile women? Summary answer Women with latent GTB have lower ovarian reserves and yield lower numbers of oocytes in IVF. What is known already Limited evidence suggests that women wit…
Weld ED, Dooley KE
Children and pregnant and postpartum women experience an undue burden of HIV-associated tuberculosis (TB), but data are lacking on key aspects of their complex management. Often excluded from clinical trials, they are left with limited options for HIV-TB cotreatment. This review …
Anchalee Avihingsanon, MD, PhD
The investigators want to know if ultra-short, effective treatment for latent tuberculosis (TB) infection (LTBI) could dramatically reduce the global incidence of active TB or not. The investigators hypothesize that short-course (4-week) daily isoniazid/rifapentine (INH/RPT) (1HP…
Tesfaye F, Sturegård E, Walles J, Winqvist N, Balcha TT, et al.
Borderline interferon-gamma (IFN-γ) results (near the cut-off level 0.35 IU/ml) occur in QuantiFERON (QFT) assays. We investigated the performance of alternative biomarkers for classification of latent tuberculosis infection (LTBI) status in pregnant women with borderline QFT IFN…
Richard E. Chaisson, MD, Susan Swindells, MBBS
HIV-infected people have an increased risk of developing active tuberculosis (TB). At the time the study was designed, the standard course of treatment for TB was 6 to 9 months of isoniazid (INH).This study compared the safety and effectiveness of a 4-week regimen of rifapentine …
National Institute of Allergy and Infectious Diseases (NIAID)
The purpose of this research is to further study the tuberculosis (TB) vaccine, Bacillus Calmette Guérin (BCG). The goal of this study is to evaluate whether the BCG vaccine is more effective in preventing TB in adults if it is given after 6 months of treatment with a widely used…
Lubyayi L, Mawa PA, Nabakooza G, Nakibuule M, Tushabe JV, et al.
Background: BCG has low efficacy in tropical countries. We hypothesized that maternal latent Mycobacterium tuberculosis (M.tb) infection (LTBI) results in fetal tolerance to mycobacterial antigens and impaired responses to BCG immunization. Methods: We enrolled 132 LTBI-positive …
Kim HY, Hanrahan CF, Martinson N, Golub JE, Dowdy DW
Objective To estimate the incremental cost-effectiveness of universal vs. test-directed treatment of latent tuberculous infection (LTBI) among human immunodeficiency virus (HIV) positive pregnant women in South Africa. Methods We compared tuberculin skin test (TST) directed isoni…
Per Björkman, Professor
Current diagnostic tools such as interferon gamma release assay (IGRA) and purified protein derivative (PPD) can not distinguish patients with latent tuberculosis infection (LTBI) and persistence of live mycobacteria. This inability to rule out living mycobacteria in patients inv…
Dick Menzies
Rationale: Shorter regimens of high dose daily rifampin may be safe, and as effective as the standard rifampin regimen when taken for 4 months to treat latent TB (LTBI). However, there is insufficient evidence on the optimal dose of rifampin that has similar efficacy as the stan…
BOURGARIT Anne
Tuberculosis is a current infection during HIV infection. After infectious contact, some patients will develop tuberculosis some will only be infected without symptoms, they have Latent Tuberculosis Infection (LTBI) which can reactivate later.In order to prevent this tuberculosis…
Miguel Santín
Objective To determine if treatment completion with a 4-month rifampin (4R) or 3-month rifapentine (P) + isoniazid (H) weekly for 12 weeks (3HP) regimens is better than with a 3-month (3HR) regimen for treatment of latent tuberculosis (TB) infection (LTBI) in patients with end st…
Damayanti Yengkhom, Grace Montepiedra, Gaerolwe Masheto, Deo Wabwire, Lynda Stranix-Chibanda, et al.
**BACKGROUND:** Tuberculosis (TB) has significant morbidity in pregnant and postpartum women with HIV (pregnant and PPWWHIV). TB preventive therapy (TPT) is recommended in pregnant and PPWWHIV with documented or presumed latent TB infection (LTBI). TB-stimulated IFNγ releas…