Showing 101–125 of 200 documents
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Enono Yhoshu, Deepak K Garnaik, Soumya Kashiv, Nowneet Bhat, Rajat Piplani, et al.
Aims Abdominal tuberculosis (TB) continues to be a common and challenging abdominal disease in children, with a nonspecific clinical presentation and poor outcomes in delayed diagnosis and complicated cases. We aimed to prospectively evaluate the clinical features and diagnostic …
Devraj Regmi, Purnakala Regmi, Sarbada Shrestha
Background: Delay in the diagnosis of tuberculosis can lead to an increased inactivity period, delayed treatment, and increased disease severity. The objective of this study was to identify the magnitude of the delay and the factors causing a delay in the diagnosis of Tuberculosi…
Pınar Etiz, Ali Tanju Altunsu
…xamine the epidemiologic features and treatment outcomes of pediatric pulmonary tuberculosis cases who were registered to the Adana Tuberculosis Dispensaries. Materials and Methods: Fifty-six pediatric patients aged 0-18 years with the diagnosis of pulmonary tuberculosis were exa…
Salih Cesur
Tuberculosis is an infectious disease whose diagnosis dates back to very early ages, which still maintains its importance in the world and in our country, can be treated and prevented with preventive (prophylactic) treatment. It is one of the leading causes of death in HIV/AIDS p…
Velasco-Arnaiz E, Pérez E, Henares D, Fernández-López A, Valls A, et al.
…lcitonin (PCT) levels have been reported in adult pulmonary tuberculosis (TB) but have not been previously investigated in children. We aimed to assess PCT levels at diagnosis of TB in young children in a low-burden setting. In a cross-sectional observational study in a referral …
Christian Diamant Mossoro‐Kpinde, Honorat Nouzoukem, Marcel Mbeko Simaléko, Nina Esther Ngoyi Ontsira, Hermione Dahlia Mossoro-Kpinde, et al.
Background and Objective: Tuberculosis is one of the leading causes of morbi-mortality, especially in developing countries, due to delayed diagnosis and management. The goal of this study is to assess the contribution of lipoarabinomannan (LAM) in improving tuberculosis (TB) diag…
Ayling Sanjaya
The diagnosis of pediatric TB is based on history taking, clinical symptoms, physical examination and support. In recent years the role of microRNA (miRNA or miR) has become a concern for researchers as biomarkers of diagnosis and therapy in TB in adults and children. MicroRNA is…
M K, S S, S M
Tuberculosis (TB) is a preventable and curable disease, but increased mortality and morbidity associated with TB is one of the leading causes of deaths worldwide. MicroRNAs (miRNAs) are small, non-coding RNAs known to regulate the host immune response against TB. We investigated …
Concepcion NDP, Laya BF, Andronikou S, Abdul Manaf Z, Atienza MIM, et al.
Tuberculosis (TB) remains a global health problem and is the second leading cause of death from a single infectious agent, behind the novel coronavirus disease of 2019. Children are amongst the most vulnerable groups affected by TB, and imaging manifestations are different in chi…
Chatterjee S, Banta A
Introduction Pediatric spinal tuberculosis is characterized by rapid bone destruction and carries the risk of rapid onset neurological deficits and severe deformity of the spine. Behavior of spinal deformity over time is affected by growth of spine. Owing to this dynamic behavior…
Santiago Atehortúa-Muñoz, Andrea Cardona-Moreno, Laura Niño-Quiroga, Javier Orlando Contreras-Ortiz, Catalina Arango-Ferreira
Abstract Objective Diagnosis of pulmonary tuberculosis (PTB) in pediatrics is a challenge due to the paucibacillary condition of the disease in this population, low sputum expectoration, and diverse unspecific symptomatology. Mycobacterial isolation through culture remains a prio…
Dhruv Gandhi, Meenakshi Dey, Sonal Patil, Dhruv Mamtora, Ira Shah
Abstract Background The diagnosis of pediatric tuberculosis (TB) remains challenging due to difficulties in specimen collection and the paucibacillary nature of the disease. While Mycobacteria Growth Indicator Tube (MGIT) culture is the gold standard, its long turnaround time lim…
Battaglia CSP, Parente AAAI, Luiz RR, Aurilio RB, Pinheiro MAS, et al.
Objectives To evaluate the contribution of Ultra to the diagnosis of pediatric pulmonary tuberculosis (PTB). Methods We analyzed prospective data from children and adolescents with presumed PTB whose specimens were tested with Ultra between January 2020 and December 2022. Diagnos…
Wiwiek Setiowulan, redi rulandani, Helmy Rachman
Pediatric drug reaction with eosinophilia and systemic symptoms (DRESS) is a life-threatening uncommon disease that can be difficult to diagnose. We present a case of a 10-year old girl with ten days of high fever during her fifth week of ATT (consisting of isoniazid, rifampicin,…
Kaba Ö, Kara M, Odacılar CA, Kamer İ, Sütçü M, et al.
Aim Extrapulmonary tuberculosis is observed more frequently and leads to complications with a higher rate in children compared with adults because the risk of lymphohematogen spread is higher. In this study, the clinical, laboratory, and radiologic findings and treatment outcomes…
Heather J. Zar, Mark P. Nicol
Pediatric tuberculosis is a global concern, with children estimated to account for 10% to 15% of the overall case load, representing almost 1 million cases annually. However, modeling estimates indicate that only 30% of childhood tuberculosis cases are diagnosed and notified.1 Di…
Mgode GF, Cox CL, Mwimanzi S, Mulder C
Background Tuberculosis (TB) diagnosis in children is a challenge with up to 94% of children with TB treated empirically in TB high-burden countries. Therefore, new diagnostic tests are needed for TB diagnosis. We determined the performance of trained rats in the diagnosis of ped…
Sushil Kumar Kabra
Diagnosis of Tuberculosis in children is challenging. Major challenge is because of difficulty in obtaining representative airway samples and paucibacillary nature of illness. Significant improvement occurred over past few years. However, the sensitivity and specificity of labora…
Kaur H, Guglani V, Singhal L, Randev S, Kumar P, et al.
Background Microbiological diagnosis of pediatric tuberculosis (TB) using conventional microbiological techniques has been challenging due to paucibacillary nature of the disease. Molecular methods using cartridge-based tests like Xpert, have immensely improved diagnosis. A novel…
Druszczynska M, Seweryn M, Wawrocki S, Pankowska A, Kulbachko A, et al.
Background Accurate diagnosis of tuberculosis (TB) in children continues to be challenging, primarily due to the low bacterial load characteristic of the disease and the obstacles in collecting sputum samples. Furthermore, detecting cases of latent Mycobacterium tuberculosis (M.t…
Kanjanaphan T
Background Tuberculosis (TB) is an important public health problem, and airborne transmission is easily transmitted. Latent TB infection (LTBI) detection and treatment is the key strategy to prevent TB. Objective This study aimed to perform contact investigation of LTBI in health…
Yalçın Kara
Tuberculosis is an infectious disease caused by the Mycobacterium tuberculosis bacteria with high mortality and morbidity. Especially, delay in diagnosis and treatment of childhood tuberculosis causes an increase in adult tuberculosis. According to the World Health Organization, …
Jakhar S, Bitzer AA, Stromberg LR, Mukundan H
Tuberculosis (TB) is a major public health concern for all ages. However, the disease presents a larger challenge in pediatric populations, partially owing to the lack of reliable diagnostic standards for the early identification of infection. Currently, there are no biomarkers t…
Dilia Fontalvo-Rivera, Maria Daniels-García, Jesly Doria-Atencia, Karen Tous-Barrios, Liliana Molinares-Núñez, et al.
**UNLABELLED:** The diagnosis of extrapulmonary tuberculosis (EPTB) in children is challenging due to the variable and nonspecific manifestations and the low rate of M. tuberculosis isolations which delayed diagnosis, leading to an increase in cases with unfavorable outcomes. **…
Zhu J, Chen N, Shang Y, Feng Y
… distress syndrome (ARDS) is a rare complication of miliary tuberculosis, particularly in pediatric patients. Comorbidities and delayed diagnosis can worsen the prognosis of patients with miliary tuberculosis. A 12-year-old girl presented with fever for 20 days, and cough and tac…