Showing 101–125 of 200 documents
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Seki M, Kim CK, Hayakawa S, Mitarai S
…iagnostic methodologies for TB, and the impact of those new diagnostics on TB control in such situations. Moreover, the perspective of TB management based on laboratory examinations is described. Smear microscopy with sputum samples is the only laboratory examination available in…
Yifan Tang, Cheng Chen, Mingming Chen, Kai Wang, Sifan Wang, et al.
**BACKGROUND:** Tuberculosis (TB) remains a major public health concern. Despite improved diagnostic tools, delays in TB diagnosis persist and hinder control efforts. **OBJECTIVE:** This study aims to investigate the spatiotemporal patterns of TB diagnostic delay and identify in…
Suneja M, Beekmann SE, Dhaliwal G, Miller AC, Polgreen PM
Objectives Diagnostic delays are a major source of morbidity and mortality. Despite the adverse outcomes associated with diagnostic delays, few studies have examined the incidence and factors that influence diagnostic delays for different infectious diseases. The objective of thi…
B Bermawi, Dewi Kurniasari, Ayunda Imaniar, Nurul Hidayatih, Diana Arum Lisnawati, et al.
INTRODUCTION: Tuberculosis (TB) is a serious global health problem in Indonesia, which is the country with the secondhighest TB burden after India. Accuracy in TB diagnosis is the key to effective treatment and decreased transmission rate. One of the latest diagnostic methods is …
Liu XT, Dong XL, Zhang Y, Fang P, Shi HY, et al.
Background Pleural effusions occur for various reasons, and their diagnosis remains challenging despite the availability of different diagnostic modalities. Medical thoracoscopy (MT) can be used for both diagnostic and therapeutic purposes, especially in patients with undiagnosed…
Yan Z, Wen JX, Wang H, Jiang TW, Huang JH, et al.
Background This study aimed to evaluate the diagnostic accuracy of pleural fluid (PF) lactate dehydrogenase (LDH) to adenosine deaminase (ADA) (LDH/ADA) ratio for tuberculous pleural effusion (TPE). Especially to explore whether the LDH/ADA ratio provides added diagnostic value t…
Bermawi B, Kurniasari DW, Imaniar A, Hidayatih N, Lisnawati DA, et al.
Introduction Tuberculosis (TB) is a serious global health problem in Indonesia, which is the country with the secondhighest TB burden after India. Accuracy in TB diagnosis is the key to effective treatment and decreased transmission rate. One of the latest diagnostic methods is i…
Tan Kah Shien, Mas Fazlin Mohamad Jailaini, Azat Azrai Azmel, Vijayan Munusamy, Arvindran Alaga, et al.
**BACKGROUND:** Tuberculous pleural effusion (TPE) remains a diagnostic challenge, particularly in tuberculosis-endemic regions. Pleural fluid adenosine deaminase (pfADA) is widely used as a diagnostic biomarker; however, its optimal cutoff value may vary depending on the epidemi…
Tennis Tomo Camagu Potelwa
In the HIV/TB endemic public care setting of the Western Cape, diagnostic consideration of patients with persistent lymphadenopathy is focused towards extra- pulmonary tuberculosis (EPTB), more than other infectious or malignant causes of lymphadenopathy. We investigated patients…
Kay A, Vasiliu A, Carratala-Castro L, Mtafya B, Mendez Reyes JE, et al.
…Reliance on sputum as the primary specimen for tuberculosis diagnostics contributes to this diagnostic gap. We evaluated the diagnostic accuracy and additive yield of a novel stool quantitative PCR (qPCR) assay for the diagnosis of tuberculosis in three countries in Africa with h…
Peng L, Ma W, Zhong L, Yang J, Wu H, et al.
The aim of this study was to evaluate the diagnostic accuracy of the IGRA, TST, and TBST by combining diagnostic test accuracy (DTA) analysis and network meta-analysis (NMA) to increase the reliability and accuracy of diagnostic methods and promote the eradication of TB. An elect…
Brooke E Nichols, Alexandra de Nooy, Naseem Cassim, Lucia Hans, Manuel Pedro da Silva, et al.
ABSTRACT To ensure there is adequate investment into diagnostics, an understanding of the magnitude of impact and return on investment is necessary. We therefore sought to understand the health and economic impacts of the molecular diagnostic programme in South Africa, to deepen …
Xuegang Zhou, Nan Tang, Xiuqing Liao, Xiaoli Bao
**BACKGROUND:** Bronchoalveolar lavage fluid (BALF) Xpert Mycobacterium tuberculosis and rifampicin resistance (Xpert MTB/RIF) is increasingly used as an important diagnostic method for sputum smear-negative pulmonary tuberculosis (PTB) in many countries. However, no studies have…
He Y, Zhu Z, Chen Y, Chen F, Wang Y, et al.
Objectives Differentiating Crohn's disease (CD) from intestinal tuberculosis (ITB) remains a diagnostic challenge. Misdiagnosis carries potential grave implications. We aimed to develop and validate a novel diagnostic nomogram for differentiating them. Methods In total, 310 eligi…
Vijay Pratap, Astha Lalwani, Ankur Malhotra
…synechiae were seen in 46% and 18%, respectively. Molecular diagnostics GeneXpert and tuberculosis-polymerase chain reaction (TB-PCR) showed high sensitivity (up to 100%) and varied specificity (33% to 100%). The prevalence of FGTB ranged from 6.73% to 45%, with conception rates …
Miller AC, Arakkal AT, Koeneman SH, Cavanaugh JE, Polgreen PM
Objectives A first step in studying diagnostic delays is to select the signs, symptoms and alternative diseases that represent missed diagnostic opportunities. Because this step is labor intensive requiring exhaustive literature reviews, we developed machine learning approaches t…
Zhang M, Li D, Hu ZD, Huang YL
Tuberculosis pleural effusion (TPE) is common in clinical practice, and its diagnosis remains a challenge for clinicians. Ziehl-Neelsen staining, PE Mycobacterium tuberculosis culture, and biopsy are the gold standards for TPE diagnosis; however, they are time-consuming, invasive…
Birendra Gupta, Natalia Blanco, Chandramani Wagle, Nikita Acharya, Jyoti Takanche, et al.
**BACKGROUND:** Pyrexia of Unknown Origin (PUO) represents a persistent diagnostic challenge in clinical practice. In South Asian regions, this challenge is compounded by a high burden of endemic infections, resource constraints, and varied clinical practices. This systematic rev…
Srivastava S, Singh PK, Vatsalya V, Karch RC
Objectives Diagnostics is the first step for the treatment and eradication of infectious microbial diseases. Due to ever evolving pathogens and emerging new diseases, there is an urgent need to identify suitable diagnostic techniques for better management of each disease. The suc…
Du J, Shu W, Liu Y, Wang Y, Zhan Y, et al.
…l external quality assessment (EQA) panels for molecular TB diagnostics. In addition, we also assessed the performance of the laboratories with the EQA panels in China. Dried Mycobacterium tuberculosis (MTB) DNA in the chelex resin was designed as part of an EQA program. The stor…
A. de Nooy
…agnostic care cascade. In many contexts, access to accurate diagnostics can be limited or delayed, with this contributing to onwards transmission and poorer health outcomes. Substantial investment in the research, development, and implementation of affordable, scalable, and conte…
Olivier Marcy, MD, PhD, Maryline Bonnet, MD, PhD, Eric Wobudeya, MD, PhD
TB-Speed SAM is a multicentric, prospective diagnostic cohort study conducted in two countries with high and very high TB incidence (Uganda and Zambia). It aims at assessing several diagnostic tests that could result in the development of a score and algorithm for TB treatment de…
Lucy Mupfumi, Tapson Nyondo, Judith Mzyece, V. Kampira, Moussa Condé, et al.
…ators to reaching universal access to WHO-recommended rapid diagnostics (WRDs) in a selection of African countries. Data for 24 African countries were sourced from the WHO Global TB database to evaluate the proportion of notified people with TB tested with a WRD between 2021 and …
Muhammad Nusrullah, Afeera Hamid, Muhammad Rashid, Hafiz Muhammad Taha Waqas, Abdul Rauf
Fiberoptic bronchoscopy with bronchial washing is done for diagnosis of pulmonary tuberculosis among patients who cannot produce sputum spontaneously. Aim: To evaluate the diagnostic yield of Fiberoptic Bronchoscopy for detection of positive cases in cases of Smear negative pulmo…
Olivier Marcy, PhD, Maryline Bonnet, PhD, Eric Wobudeya, PhD
The TB-Speed Decentralisation study aims to increase childhood Tuberculosis (TB) case detection at district hospital (DH) and Primary health Care (PHC) levels using adapted and child-friendly specimen collection methods, i.e. Nasopharyngeal Aspirate (NPA) and stool samples, sensi…