Showing 101–125 of 200 documents
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V Crudu, S Alexandru, N Ciobanu, A Codreanu, E Noroc, et al.
<b>Significance:</b> Molecular methods, in special WGS, can provide a comprehensive analysis of <i>M.tuberculosis</i> mutations that cause resistance to anti-tuberculosis drugs. However, direct sequencing from clinical specimens to provide a full drug resistance profile remains a…
Dr Nagaraja B S
Background: There is paucity of data regarding the diagnostic role of cartridge-based nucleic acid amplification test (CBNAAT), in the diagnosis of drug resistant sputum smear-negative PTB cases. Aim: To determine the diagnostic role of CBNAAT in detecting drug resistance smear n…
Khushvakhtov S, Davtyan H, Alaverdyan S, Harries AD, Kabirov O, et al.
Introduction Tajikistan is scaling up molecular diagnostic and digital technologies to strengthen its fight against drug-resistant TB (DR-TB). The study aimed to document national scale-up GeneXpert/GxAlert and Open MRS from 2012-2019 and compare time taken from TB diagnosis to t…
Mwaba P, Chakaya JM, Petersen E, Wejse C, Zumla A, et al.
An estimated 1.8 billion people worldwide have a latent tuberculosis infection (LTBI), with wide variations in LTBI rates across countries. LTBI can be due to infection with either drug-sensitive or drug-resistant Mycobacterium tuberculosis (Mtb) strains. Accurate data on the pre…
Raunak Bir, Urvashi B Singh, Hitender Gautam, Nishant Verma, Kiran Bala, et al.
**BACKGROUND:** Relapse and default cases of pulmonary tuberculosis (PTB) present a significant challenge due to higher bacillary loads and the increased risk of developing multidrug-resistant tuberculosis (MDR-TB). Conventional diagnostic methods, such as smear microscopy, lack …
Indira Basu
According to a recent World Health Organization report, tuberculosis (TB), an ancient disease with an enormous global impact, still ranks in the top ten causes of death worldwide. Pulmonary TB, where patients show symptoms like cough, fever, night sweat and weight-loss is highly …
C S Kamela, Corresp Ng, Jean Claude Semuto Ngabonziza, Pauline Lempens, Bouke C. de Jong, et al.
Background.Mycobacterium tuberculosis rapid diagnostic tests (RDTs) are widely employed in routine laboratories and national surveys for detection of rifampicin-resistant (RR)-TB.However, as next generation sequencing technologies have become more commonplace in research and surv…
Background.Mycobacterium tuberculosis rapid diagnostic tests (RDTs) are widely employed in routine laboratories and national surveys for detection of rifampicin-resistant (RR)-TB.However, as next generation sequencing technologies have become more commonplace in research and surv…
Ma Z, Ji X, Yang H, He J, Zhang Q, et al.
In recent years, the prevalence of tuberculosis worldwide has increased, and with it, the number of drug-resistant tuberculosis strains. This has brought new challenges towards prevention and control of the disease. Therefore, it is urgent to find reliable and rapid diagnostic me…
Singh BK, Sharma R, Kodan P, Soneja M, Jorwal P, et al.
Background Line probe assay (LPA) is standard diagnostic tool to detect multidrug resistant tuberculosis. Noninterpretable (NI) results in LPA (complete missing or light wild-type 3 and 8 bands with no mutation band in rpoB gene region) poses a diagnostic challenge. Methods Sputu…
Venkateswari Ramachandra, Usharani Brammacharry, Aaina Muralidhar, Anbazhagi Muthukumar, Revathi Mani, et al.
GeneXpert MTB/RIF is a rapid molecular diagnostic tool capable of simultaneously detecting Mycobacterium tuberculosis and rifampicin resistance. This study aimed to assess the diagnostic precision of GeneXpert MTB/RIF assay to detect pulmonary and extrapulmonary tuberculosis and …
Ng KCS, Ngabonziza JCS, Lempens P, de Jong BC, van Leth F, et al.
Background Mycobacterium tuberculosis rapid diagnostic tests (RDTs) are widely employed in routine laboratories and national surveys for detection of rifampicin-resistant (RR)-TB. However, as next-generation sequencing technologies have become more commonplace in research and sur…
Benoît Schwartz, Vincent Dupont, Sandra Dury, Aline Carsin-Vu, Thomas Guillard, et al.
OBJECTIVES: To assess the aetiology, clinical features, diagnostic studies and outcomes of community-acquired pneumonia (CAP) in a French cohort of hospitalized kidney transplant recipients. METHODS: We performed a retrospective, multicentre study in kidney transplant recipients …
Tenakanai ND, Banamu JK, Lin Y, Walsh D, Simbil R, et al.
Setting Papua New Guinea is a high-burden multidrug-resistant TB (MDR/RR-TB) country that reports low rates of bacteriological confirmation. Sputum drug susceptibility testing for second-line drugs is important. Access to culture is limited. Objective To evaluate the prevalence o…
Hamilton DO, Vas Nunes J, Grobusch MP
…und, some facilities in the country have access to improved diagnostics, including Xpert MTB/RIF testing, of particular use in diagnosing those at risk of drug resistance, in the form of rifampicin-resistant (RR) TB. This quality improvement project describes how a small, rural d…
Venkateswari Ramachandra, Usharani Brammacharry, Aaina Muralidhar, Anbazhagi Muthukumar, Revathi Mani, et al.
Xpert MTB/RIF is rapid molecular diagnostic tool capable of simultaneously detecting Mycobacterium tuberculosis and rifampicin resistance. This study aimed to access the diagnostic precision of Xpert MTB/RIF assay to detect pulmonary and extra-pulmonary tuberculosis and to evalua…
Umesh Kumar Patil, Sujatha Vijaykumar
Multidrug-resistant tuberculosis (MDR-TB) poses a significant challenge to global health, necessitating rapid and accurate diagnostic methods to ensure timely treatment and control. This review explores the current and emerging diagnostic technologies for MDR-TB, emphasizing thei…
World Health Organization
This consolidated WHO guideline provides evidence-based recommendations on rapid diagnostic technologies for the detection of tuberculosis (TB) and drug-resistant TB. Developed within the framework of the WHO End TB Strategy and global commitments adopted at the 2018 United Natio…
Ng KCS, Supply P, Cobelens FGJ, Gaudin C, Gonzalez-Martin J, et al.
Rifampin heteroresistance-where rifampin-resistant and -susceptible tuberculosis (TB) bacilli coexist-may result in failed standard TB treatment and potential spread of rifampin-resistant strains. The detection of rifampin heteroresistance in routine rapid diagnostic tests (RDTs)…
Kajal, Sharma D, Rai R
Tuberculosis (TB) is one of the major infectious disease that causes threat to human health and leads to death in most of the cases. Mycobacterium tuberculosis is the causative agent that can affect both pulmonary and extra pulmonary regions of the body. This infection can be pre…
Baum SE, Pelissari DM, Dockhorn Costa F, Harada LO, Sanchez M, et al.
Effectively responding to drug-resistant tuberculosis (TB) requires accurate and timely information on resistance levels and trends. In contexts where use of drug susceptibility testing has not been universal (i.e. not all patients are offered testing), surveillance for rifampici…
B. Shirly Suzana, K Aravind Kumar Reddy, Shipra Bhargava, Manisha Chauhan
Owing to the drastic increase in the number of patients with drug resistant TB around the world, it is important to increase the testing for it. Line probe assay (LPA) is the rapid diagnostic tool to detect drug resistant TB and it was endorsed by WHO for testing first line drugs…
Nunung Dartini Wahyuningtyas, Osman Sianipar, Andaru Dahesihdewi
Tuberculosis (TB) is a global health problem and is the leading cause of morbidity and mortality in many developing countries. Multi Drug Resistant Tuberculosis (MDR TB) becomes one burden of health problems considering the high morbidity and mortality rates. Establishment of MDR…
World Health Organization. Regional Office for Europe
The European Tuberculosis Laboratory Initiative (ELI), with its secretariat at the WHO Regional Office for Europe, has developed this technical document to address the need in the WHO European Region for increasing timely and accurate detection of tuberculosis (TB) and multidrug-…
Jorwal P, Singh BK, Anand A, Khan F, Khandelwal K, et al.
…quired almost same as compared with previously approved WHO diagnostics used in resource-limited countries.