Showing 101–125 of 200 documents
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Jungho Kim
Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), is a major global health concern.Approximately one-third of individuals globally harbors latent TB infection (LTBI), posing a significant challenge as 5%-10% of those infected may develop active TB, especially …
Marcus Bauer, Anke Hildebrandt
**BACKGROUND:** Dyspnea is a common clinical symptom and cause of outpatient and inpatient presentations to the clinic. Diagnostic and therapeutic challenges appear, when additional diseases appear that are themselves associated with subjectively perceptible dyspnea. We report on…
Jae Jin Lee, Young Jae Kim, Eun-jin Park, Keun Choi, Hyungjin Eoh
Tuberculosis (TB) remains a global public health crisis, responsible for approximately 1.3 million deaths annually.The effectiveness of current chemotherapy is limited by its inability to eradicate persister populations of Mycobacterium tuberculosis (Mtb), a minor fraction of phe…
Alba Ruedas-López, Juan María Herrero-Martínez, Alhena Reyes, Beatriz González-Blanco, Paula López-Roa
The Quantiferon Gold Plus (QFT) test, a widely used interferon-γ release assay (IGRA), diagnoses latent tuberculosis infection (LTBI) with a positivity threshold of ≥0.35 IU/mL. Results near this cut-off can be challenging to interpret due to variability from immunol…
Luke M. Nelson, Kira Yates, Armando Ugarte, Katrina Chin Loy, Miriam Michael, et al.
Abstract Purpose: To describe a case of cytomegalovirus (CMV) anterior uveitis misdiagnosed as presumed ocular tuberculosis (TB) in an immunocompetent immigrant patient, leading to delayed diagnosis, corneal graft failure, and eventual vision loss. Observations: A 74-year-old Fil…
Isadora Oliveira Corrêa, Gabriel Chaves Silva de Almeida, Ana Paula Menegotto Petit Woyciekowki, Felix Arthur Bernardes
Differentiating Crohn’s disease (CD) from intestinal tuberculosis (IT) is challenging due to overlapping clinical, histological, and endoscopic findings. Screening for latent tuberculosis with PPD or IGRA is essential before immunosuppression; however, anergy in active CD may yie…
Luke M. Nelson, Kira Yates, Armando Ugarte, Katrina Chin Loy, Miriam Michael, et al.
Abstract Purpose: To describe a case of cytomegalovirus (CMV) anterior uveitis misdiagnosed as presumed ocular tuberculosis (TB) in an immunocompetent immigrant patient, leading to delayed diagnosis, corneal graft failure, and eventual vision loss. Observations: A 74-year-old Fil…
Wang J, Jiang F, Cheng P, Ye Z, Li L, et al.
Tuberculosis (TB) is an infectious disease that significantly threatens human health. However, the differential diagnosis of latent tuberculosis infection (LTBI) and active tuberculosis (ATB) remains a challenge for clinicians in early detection and preventive intervention. In th…
Chenxi Li, Xiangyuan Chen, Ping Zeng
Latent tuberculosis infection (LTBI) is a state of sustained immune response to Mycobacterium tuberculosis (MTB) antigens, without clinical evidence of active tuberculosis. Rheumatic diseases, a common type of autoimmune disease, are often treated with glucocorticoids, immunosupp…
Yun Xu, Xiaochun Wang, Qiangsen Zhong
Bacillus Calmette-Guérin (BCG) is the only vaccine currently used in clinical practice to prevent tuberculosis (TB), however, it remains limited in preventing latent infection, TB reactivation, and providing comprehensive protection. In this study, the pcaA gene, an antigen …
Uzorka JW, Duinkerk DL, Kroft LJM, Bakker JA, Ramai RSRS, et al.
Screening for latent tuberculosis infection (LTBI) is indicated before immunosuppressive therapies but is complicated by lack of a gold standard and limited by, e.g., immunosuppression. This study aimed to investigate a series of patients diagnosed with LTBI during screening befo…
Tongtong Shao, Li Yang, Ge Wu, Xiaobo Lu, Rongjiong Zheng
The diagnosis and treatment of tuberculosis rely on a deep understanding of the pathobiology and immune responses. This study aimed to identify potential immune response mechanisms by integrating gene expression analysis with immune cell distribution profiling to characterize the…
A. N. Kuznetsova, Е. А. Бородулина
The problem of the steady growth of HIV-associated tuberculosis has become increasingly urgent in recent years in Russia. Diagnosis of tuberculosis is particularly difficult at the stage of severe immunodeficiency. Objective. to evaluate the effectiveness of the T-SPOT ® method.T…
Introduction. Currently, diagnosis of tuberculosis and latent tuberculosis infection in children remains difficult. The study aimed to compare the results of a skin test with allergen tuberculosis recombinant (ATR), containing ESAT6 and CFP10 proteins, QuantiFERON (QFT) (Qiagen, …
Mamishi S, Mahmoudi S, Banar M, Hosseinpour Sadeghi R, Marjani M, et al.
To assess the potency of Interferon (IFN)-γ inducible protein 10 (IP-10) stimulated by recombinant PE35 and PPE68 as a biomarker in differentiating between active and latent tuberculosis. Patients with active pulmonary TB (PTB) (n = 30), latent TB infection (LTBI) (n = 29), and B…
Wang C, Hua J, He X, Chen L, Lv S
Background Autophagy is closely involved in the control of mycobacterial infection. Objectives Here, a diagnostic model was developed using the levels of autophagy-related genes (ARGs) in the blood to differentiate active tuberculosis (ATB) and latent tuberculosis infection (LTBI…
Ma Z, Li S, Liu Y, Li C, Wang X, et al.
Objective To determine the absolute number of serum T lymphocytes and cytokine levels and the characteristics of patients with active pulmonary tuberculosis and to assess their effect on the immune status of these patients and their diagnostic and predictive value for tuberculosi…
Xinru Fei, Shanshan Wang, Zhan Wang, Xinsong Hu, Cheng Chen, et al.
**UNLABELLED:** As an alternative to the tuberculin skin test (TST) or QuantiFERON-TB Gold In-Tube (QFT-GIT), ESAT6-CFP10 (EC) skin test is an emerging screening method; however, its value in the diagnosis of latent tuberculosis infection (LTBI) in detainees is still unclear in C…
Xin Zhang, Lirong Mao, Renkun Nie, Donglin Guo, Yue Su, et al.
**BACKGROUND:** The interferon-gamma release assays (IGRAs) are characterized by their complexity and reliance on specific instrumentation. The recombinant Mycobacterium tuberculosis (MTB) fusion protein skin test (C-TST) utilizes the same MTB fusion protein as IGRAs. If the C-TS…
Fengjiao Wu, Ru Huang, Yuxuan Lin, Xixi Zhu, Yujie Li, et al.
Tuberculosis (TB), caused by(MTB), remains a major global health problem. Drug resistance and the limitations of sputum-based diagnostic methods highlight the need for additional host-response biomarkers. Protein tyrosine phosphatase receptor type O (PTPRO) has been implicated in…
Iqbal SA, Isenhour CJ, Mazurek G, Truman BI
OBJECTIVE: To measure the frequency of diseases related to latent tuberculosis infection (LTBI) and tuberculosis (TB), we assessed the agreement between diagnosis codes for TB or LTBI in electronic health records (EHRs) and insurance claims for the same person. METHODS: In a US p…
Ananthi Rajendran, Ahmed Kabir Refaya, Balaji Subramanyam, Ramesh Karunaianantham, Dhandapani RaviKumar, et al.
Pyrazinamide (PZA) plays a crucial role in the treatment of both active and latent tuberculosis, particularly in regimens designed to treat drug-resistant TB. However, diagnosing resistance to PZA poses challenges for managing TB, highlighting the need for accurate detection meth…
Pettit AC, Stout JE, Belknap R, Benson CA, Séraphin MN, et al.
Background Increased risk of progression from latent tuberculosis infection (LTBI) to tuberculosis (TB) disease among people living with human immunodeficiency virus (HIV; PLWH) prioritizes them for LTBI testing and treatment. Studies comparing the performance of interferon gamma…
Ovi Rusmariza, Muhammad Nasrum Massi, Rizalinda Sjahril, Handayani, Zainul Muttaqin, et al.
**BACKGROUND:** Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis, one of which involves miR-146a-5p as a specific microRNA molecule that is expressed exclusively on immune cells to modulate innate immunity. This study aims to examine and compare the…
Julie G. Burel, Cecilia S. Lindestam Arlehamn, Mikhail Pomaznoy, Grégory Seumois, Jason Greenbaum, et al.
Abstract As part of the Human Immune Project Consortium (HIPC) program, we are aiming to decipher CD4 T cell immune signatures of tuberculosis (TB) in the context of controlled (latent TB) and uncontrolled (active TB) infection. We found commonalities and differences in TB-specif…