Showing 101–125 of 200 documents
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Weicong Ren, Mengjie Yang, You Zhou, Yinghui Yang, Haoran Li, et al.
**BACKGROUND:** Tuberculous pleurisy (TP), a predominant form of extrapulmonary tuberculosis, presents significant diagnostic challenges attributable to the paucibacillary nature of pleural effusion (PE) specimens. Cell-free Mycobacterium tuberculosis (MTB) DNA in PE represents a…
Shalu Jain, Rajeswar Dayal, Raj Kamal, Dharmendra Singh, Neeraj Yadav, et al.
Tuberculous meningitis (TBM) poses a diagnostic challenge in children. The available conventional diagnostic methods have low sensitivity. Cartridge-based nucleic acid amplification test (CBNAAT) requires suitable infrastructure and technical expertise. TB loop-mediated isotherma…
Yoo SD, Abebe G, Yoo JE, Regassa D, Bezabih M
Background Tuberculous pleuritis (TBP) is a common extrapulmonary tuberculosis that contributes to the tuberculosis burden. Xpert MTB/RIF assay is a promising method for rapid diagnosis of TBP. The diagnostic value of Xpert MTB/RIF assay in pleural tissue obtained via closed pleu…
Patel S, Dadheech M, Sahu P, Pathe C, Singh J, et al.
Background Tuberculous meningitis (TBM) is a challenging condition to diagnose, and current laboratory methods have limitations, especially in developing countries. This study evaluated the diagnostic utility of the Lancet consensus scoring (LCS) system in suspected TBM cases at …
Yufang Liang, Dailun Hou
F-FDG PET/CT), and artificial intelligence (AI), early identification of TB has been provided. This paper systematically reviews the consensus and key literature on diagnostic imaging of TB in national and international journals between October 2023 and September 2024 to improve …
Habib A, Amin ZA, Raza SH, Aamir S
Objective To determine diagnostic accuracy of Cerebro Spinal Fluid (CSF) Adenosine De-Aminase (ADA) in detecting Tuberculous Meningitis (TBM) keeping CSF Polymerase Chain Reaction (PCR) for Mycobacterium Deoxy Ribonucleic Acid (DNA) as gold standard. Methods This cross sectional …
Wang Y, Jin F, Mao W, Yu Y, Xu W
The diagnosis of tuberculosis depends on detecting Mycobacterium tuberculosis (Mtb). Unfortunately, recognizing patients with extrapulmonary tuberculosis (EPTB) remains challenging due to the insidious clinical presentation and poor performance of diagnostic tests. To identify bi…
Purohit MR, Purohit R, Mustafa T
Objective We aimed to investigate the awareness, health care seeking behavior, and diagnostic delay in extrapulmonary tuberculosis (EPTB) in a resource-constrained setting from Central India. Setting and method Questionnaire based interview of 1220 EPTB patients ≥14 years of age …
Huang L, Niu Y, Zhang L, Yang R, Wu M
Purpose This study aimed to assess the efficacy of chemiluminescence-based urinary lipoarabinomannan (LAM) antigen assay as a diagnostic tool for identifying active tuberculosis. Methods A retrospective study was conducted on 166 Tuberculosis (TB), 22 Non-Tuberculous Mycobacteria…
Ha TM, Huynh TC, Le TV, Nguyen AT, Nguyen CH
Background Tuberculous pleural effusion (TPE) is a common form of extrapulmonary tuberculosis and remains difficult to diagnose, particularly when distinguishing it from malignant and parapneumonic pleural effusions. Although pleural fluid adenosine deaminase (ADA) is widely used…
Gui-Xiang Jian, Yanfeng Huang
OBJECTIVE: To evaluate the diagnostic value of T-cells enzyme linked immunospot (TSPOT.TB) in the children with tuberculosis. METHODS: The clinical data was retrieved from 2 348 children who underwent TSPOT.TB test in the Children's Hospital of Chongqing Medical University from J…
Grønningen E, Nanyaro M, Ngadaya E, Mustafa T
Background Unlike pulmonary tuberculosis, there is limited information on delays in diagnosis and treatment initiation in extrapulmonary tuberculosis (EPTB) and their consequences for disease outcomes and mortality. In low- and middle-income countries, most EPTB cases are presume…
Chen YL, Zhu MM, Guan CP, Zhang YA, Wang MS
Objective This systematic review aims to evaluate the diagnostic accuracy of cerebrospinal fluid (CSF) lipoarabinomannan (LAM) assays in detecting tuberculous meningitis (TBM). Methods A systematic review search was conducted in PubMed and five other databases up to April 2023. S…
Mahboubeh Maleki Rad, Mahboubeh Haddad, Fereshte Sheybani, Matin Shirazinia, Maliheh Dadgarmoghaddam
**OBJECTIVE:** This study aimed to assess the clinical characteristics, diagnostic certainty, outcomes, and predictors of mortality in patients diagnosed with tuberculous meningitis (TBM), using the Lancet scoring system for diagnostic certainty. **METHODS:** A retrospective coh…
Li Z, Pan L, Lyu L, Li J, Jia H, et al.
Objectives Tuberculous meningitis (TBM) is difficult to diagnose. Digital PCR (dPCR) is a novel method which can quantify trace nucleic acids. This study sought to evaluate the diagnostic accuracy of dPCR analysis of cerebrospinal fluid (CSF) for TBM. Methods We collected CSF spe…
Hussein Algahtani, Bader Shirah, Nawal Abdelghaffar, Abdulrahman Alqahtani, Mohammad Dahman Alshehri
Tuberculosis is a major global public health problem, which poses significant diagnostic and treatment challenges. Tuberculous meningitis is the most severe form of extrapulmonary tuberculosis, which approximately affects 1% of all patients with active tuberculosis. It is conside…
H Alzarooni, H Molabe, F Malherbe
Breast tuberculosis (TB) is a rare form of extrapulmonary tuberculosis, accounting for 0.1% of all breast conditions globally, with a higher incidence in endemic regions such as India, East Asia, and sub-Saharan Africa. It can mimic breast carcinoma, complicating timely diagnosis…
R Bista, A Khan, A Awale, S Paul, D Thameem
Abstract Histoplasmosis and blastomycosis are dimorphic fungal infections with overlapping clinical and radiologic features, often complicating diagnosis especially in immunocompromised hosts. Expanding endemic areas likely due to cross migration and climate change and serologic …
Parviz Saleh, Yousef Ahmadi
Background: Tuberculosis is still considered as one of the major health-care problems in our country and affects annually population of 10 to 20 million TB patients. The aim of this study was to evaluate the diagnostic value of cerebrospinal fluid adenosine deaminase enzyme in tu…
Shoaib Khan, Nahid Nahvi, Umara Amin, Yousuf Ul Bashir, Danish Zahoor
Cutaneous tuberculosis (CTB) is the rarest case of extrapulmonary TB comprising 2% of total cases. It’s often a challenge both clinically and diagnostically. 1) To determine prevalence, age & gender-wise distribution of CTB. 2) To assess various diagnostic, microbiological mo…
Universidad Cuauhtémoc Aguascalientes. Aguascalientes, Mexico., Juan Fausto Martínez González, Ana Cristina González, Universidad Popular Autónoma del Estado de Puebla. Puebla, Mexico., Manuel Servı́n, et al.
…ith lupus vulgaris being the most common subtype. Molecular diagnostics (e.g., GeneXpert MTB/RIF) have improved sensitivity over traditional Ziehl-Neelsen staining. Treatment requires standard ATT regimens (e.g., 2HRZE/4HR), though drug-resistant cases necessitate tailored regime…
Tejaswini Olambe, Pooja Shah, Sae Pol, Abhilasha Belpatre, Rajesh Karyakarte
…endemic regions and emphasize the pivotal role of molecular diagnostics in recognizing atypical EPTB presentations. Early diagnosis and comprehensive follow-up are essential for optimizing patient outcomes. KEYWORDS: CBNAAT, Extra-pulmonary tuberculosis, Mycobacterium tuberculosi…
Zapata Naranjo M, Ayala Torres JD, Suarez Poveda AT, García V, Alcazar Paternina M
Tuberculosis (TB) remains a significant global health challenge, traditionally associated with pulmonary manifestations. However, extrapulmonary tuberculosis (EPTB) accounts for a substantial portion of TB cases, particularly in immunocompromised patients. EPTB can affect virtual…
Ihor Dmytrovych Duzhyi, Г.П. Олещенко, Valentyna H. Psarova
Introduction. Despite the overall positive epidemiological trend, the burden of tuberculosis in Ukraine remains significant. The most common form of extrapulmonary TB is tuberculous pleurisy. The share of the latter in the structure of all tuberculosis forms is within 10–12% or m…
André Pereira, Inês Peixoto, Ana Silva, Rosa Cardoso, Helena Sarmento
Tuberculosis (TB) remains a leading cause of infectious morbidity and mortality worldwide. Extrapulmonary TB, particularly abdominal TB, is a diagnostic challenge due to its nonspecific presentation and often low sensitivity for conventional tests. Immunocompromised patients, suc…