Showing 101–125 of 192 documents
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Ai Luo, Xuemei Liu, Qiongqiong Hu, Mei Yang, Hongli Jiang, et al.
…Systematic Reviews, Cochrane Central Register of Controlled Trials will be searched from inception to 1 March 2022 for eligible randomised controlled trials that investigating the effects of NAC on exacerbations, health-related quality of life, lung functions, sputum volume and c…
Crider K, Williams J, Qi YP, Gutman J, Yeung L, et al.
…w Types of studies Inclusion criteria Randomized controlled trials (RCTs) Quasi-RCTs with randomization at the individual or cluster level conducted in malaria-endemic areas (areas with ongoing, local malaria transmission, including areas approaching elimination, as listed in the…
Fox GJ, Nhung NV, Sy DN, Hoa NLP, Anh LTN, et al.
…tnam. Methods We performed a cluster-randomized, controlled trial at clinics in 70 districts (local government areas with an average population of approximately 500,000 in urban areas and 100,000 in rural areas) in eight provinces of Vietnam. Health workers at each district clini…
Yang Y, Cai J, Wang X, Zhao K, Lei Z, et al.
…We conducted a double-blinded placebo-controlled randomized trial in 360 pulmonary tuberculosis patients with concurrent diabetes or prediabetes. The participants were randomly assigned to receive a daily nutrition package (112 kcal, 9 g protein, and micronutrients) or a daily pl…
Lin H, Lin Y, Zheng Y, Liu Z, Chang C
… to help TB patients quit smoking, and we will evaluate the clinical efficacy of this application by using a randomised controlled trial (RCT). Methods and analysis This is a two-step study. In the first step, we will develop a smartphone application based on an interactive appli…
Cox SR, Kadam A, Atre S, Gupte AN, Sohn H, et al.
…e I effectiveness-implementation non-inferiority randomized trial to compare the effectiveness, cost-effectiveness, and feasibility of two ACF strategies among individuals who have completed TB treatment and their household contacts (HHCs). Methods We will enroll 1076 adults (≥ 1…
Dogar O, Keding A, Gabe R, Marshall AM, Huque R, et al.
…hods We did a randomised, double-blind, placebo-controlled, trial at 32 health centres in Bangladesh and Pakistan. Eligible patients were adults (aged >18 years in Bangladesh; aged >15 years in Pakistan) with pulmonary tuberculosis diagnosed in the previous 4 weeks, who smoked to…
Jennifer Phillips, Wayne Hing, Rodney Pope, Ashleigh Canov, Nicole Harley, et al.
…individuals with bronchiectasis are routinely prescribed in clinical practice and recommended by international guidelines, especially during an acute exacerbation. However, there is limited evidence of the efficacy of these techniques during an exacerbation to improve sputum expe…
Rittberg R, Leung B, Al-Hashami Z, Ho C
…atment, and survival data were collected through the Cancer Registry. Retrospective chart review was completed to extract past medical history and missing variables. CASPIAN/IMPower133 excluded patients with autoimmune diseases, active infection, and performance status (PS) ≥2. R…
Xiaorui Ruan, Kebin Chen, Ziye Li, Jianhui Wei, Ye Chen, et al.
…tions should be prioritized by antenatal care providers. **TRIAL REGISTRATION:** The study was retrospectively registered in Chinese Clinical Trial Registry Center on 06/14/2018, registration number: ChiCTR1800016635, available at: https://www.chictr.org.cn/showproj.html?proj=28…
Kartik Kumar, Saira Ghafur
…py increases the risk of treatment failure, leading to poor clinical outcomes and a significant financial burden to healthcare services. Digital health technologies may offer innovative solutions to this, but studies evaluating their utility remain sparse. To address this researc…
Christine Sekaggya-Wiltshire, Eva Agnes Laker Odongpiny, Francis Williams Ojara, Isabella Kyohairwe, Reuben Kiggundu, et al.
…tuberculosis dosing among people living with HIV (PLWH). **CLINICAL REGISTRATION:** The study is registered with Pan African Clinical Trials Registry, registration number PACTR202409710100607, registration date 07 August 2024, pactr.samrc.ac.za/TrialDisplay.aspx?TrialID=31764.
Reza TF, Nalugwa T, Farr K, Nantale M, Oyuku D, et al.
…mance Evaluation for Linkage to Tuberculosis Care (XPEL-TB) trial uses an ultra-pragmatic, hybrid type II effectiveness-implementation design to assess the effectiveness and implementation of a streamlined strategy for delivery of Xpert testing in real-world settings. Twenty heal…
Fumimaro Ito, Hideki Terai, Masahiro Kondo, Ryo Takemura, Ho Namkoong, et al.
…ies could result in individualised treatment of long COVID. TRIAL REGISTRATION NUMBER: The study protocol is registered at UMIN clinical trials registry (UMIN000042299).
Hayoung Choi, Chloe Hughes, Zsofia Eke, Morven Shuttleworth, Michal Shteinberg, et al.
…HODS: Patients from the prospective European Bronchiectasis Registry (European Multicentre Bronchiectasis Audit and Research Collaboration-Bronchiectasis Research Involving Databases, Genomics and Endotyping; ClinicalTrails.gov Identifier: NCT03791086) were enrolled. Patients fro…
Lisa M Wilson, Ian J. Saldanha, Karen A. Robinson
…f a previously published review. OBJECTIVES: To compare the clinical effectiveness of ACBT with other airway clearance therapies in CF. SEARCH METHODS: We searched the Cochrane Cystic Fibrosis Trials Register, compiled from electronic database searches and handsearching of journa…
Charan J, Goyal JP, Reljic T, Emmanuel P, Patel A, et al.
…ention of TB in CLHIV. Methods We searched PubMed, Cochrane Clinical Trial Registry and Google Scholar from inception to December 2016. Any randomized controlled trial assessing the role of isoniazid for the prevention of TB in CLHIV was eligible for inclusion. The primary endpoi…
Christie Akwaowo, Idongesit Umoh, Oluseyi Motilewa, Victor Umoh, Eno Usoroh, et al.
…ger multicomponent intervention study, a randomised control trial was conducted with CHWs in 18 primary health care (PHC) clusters in Nigeria. The clusters were allocated to three arms: training and cash incentive (A), training only (B), and control (C) arms. Arms (A) and (B) rec…
Katamba A, Mochizuki T, Nalugwa T, Nantale M, Oyuku D, et al.
… In this planned analysis of a pragmatic cluster-randomized trial in Uganda, we assessed whether a multicomponent strategy, including decentralized Xpert testing, decreased mortality among adults evaluated for TB. Methods Ten community health centers were randomized, using a comp…
Laura Olbrich, Bada Yang, Hayley Poore, Alia Razid, Brittney Sweetser, et al.
…racy of LC-aNAATs and LF-LAM separately in children, but in clinical practice the tests may be used concurrently, i.e. in 'parallel'. **OBJECTIVES:** To compare the diagnostic accuracy of the parallel use of LC-aNAAT on respiratory and stool specimens in children, and with LF-LA…
Christie Akwaowo, Idongesit Umoh, Oluseyi Motilewa, Victor Umoh, Eno Usoroh, et al.
…ger multicomponent intervention study, a randomised control trial was conducted with CHWs in 18 primary health care (PHC) clusters in Nigeria. The clusters were allocated to three arms: training and cash incentive (A), training only (B), and control (C) arms. Arms (A) and (B) rec…
Ggita JM, Katahoire A, Meyer AJ, Nansubuga E, Nalugwa T, et al.
…sehold contacts who participated in a randomized controlled trial evaluating home sputum collection and delivery of TB results via SMS (Pan-African Clinical Trials Registry #201509000877140). We asked about feelings, beliefs, decisions, and behaviors in response to the SMS result…
Andrew Arnott, Robert Hart, Scott McQueen, M. Watson, Malcolm Sim
…h secretion loads, although there are no randomised control trials evaluating its use. Novel vibrating mesh nebulisers generate a fine aerosol resulting in deeper lung penetration, potentially offering a more effective means of nebulisation in comparison to jet nebulisers. The pr…
Yuhan Bao, Chunxiang Wang, Haiping Xu, Yongjie Lai, Yupei Yan, et al.
…revention and control for pulmonary TB. </sec> <sec> <title>CLINICALTRIAL</title> Chinese Clinical Trial Registry ChiCTR2200055557; https://tinyurl.com/4ray3xnw </sec>
Lung T, Marks GB, Nhung NV, Anh NT, Hoa NLP, et al.
… are unclear due to the absence of evidence from randomised trials. We assessed the costs and cost-effectiveness of an active case finding strategy in Vietnam, where there is a high prevalence of tuberculosis. Methods We conducted an economic evaluation alongside the Active Case …