Showing 101–125 of 200 documents
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Misra UK, Kumar M, Kalita J
…le-centre, open-label, parallel group randomized controlled trial was conducted from May 2017 to June 2019 in India. Treatment-naïve patients with TBM fulfilling the inclusion criteria were randomized to four drug ATT regimens (rifampicin, isoniazid, ethambutol and pyrazinamide) …
Bethou Adhisivam, Chinnathambi Kamalarathnam, B Vishnu Bhat, Kumutha Jayaraman, Siva P Namachivayam, et al.
… **DESIGN:** Multicentre, open label, randomised controlled trial SETTING: Three tertiary neonatal intensive care units (NICUs) in southeast India. **POPULATION:** Newborn babies weighing <2000 g. 7067 were assessed for eligibility and 5420 were randomised (2714 BCG-OPV, 2706 co…
Gao L, Zhang H, Xin H, Liu J, Pan S, et al.
…rganization's End TB Strategy.In this randomised controlled trial (Chinese Clinical Trial Registry identifier ChiCTR-IOR-15007202), two short-course regimens with rifapentine plus isoniazid (a 3-month once-weekly regimen and a 2-month twice-weekly regimen) were initially designed…
Bhargava A, Bhargava M, Velayutham B, Thiruvengadam K, Watson B, et al.
…. We designed an open-label, field-based cluster randomised trial to assess the impact of nutritional supplementation (with food rations) on TB incidence in a group at higher risk of TB infection and disease, viz household contacts (HHC) of patients with microbiologically confirm…
Bao Y, Wang C, Xu H, Lai Y, Yan Y, et al.
…ior and quality of prevention and control for pulmonary TB. Trial registration Chinese Clinical Trial Registry ChiCTR2200055557; https://tinyurl.com/4ray3xnw.
Wenwen Sun, Zhengwei Dong, Yiming Zhou, Kunlong Xiong, Hongcheng Liu, et al.
…infection were detected at one time by mNGS. All mNGS-based clinical decisions were made within 2 days.Conclusions The mNGS could accurately and quickly detect fungi and mycobacteria in FFPE specimens from postoperative granuloma specimens and identify the pathogens to the specie…
Kumwichar P, Prappre T, Chongsuvivatwong V
… conversion rates in a 60-day cluster randomized controlled trial with patients with pulmonary tuberculosis (VOT: n=63 and DOT: n=65) with positive sputum acid-fast bacilli smears and 38 observers equally randomized into the VOT and DOT groups (19 observers per group and n=1-5 pa…
Kumwichar P, Chongsuvivatwong V, Prappre T
…se of TB treatment. Methods A cluster randomized controlled trial of pulmonary TB patients and their observers will be conducted over a 2-month period. This study will be conducted in the Hat Yai and Meuang Songkhla districts of Songkhla Province, Southern Thailand. A total of 38…
He CX, Wu C, Zhang L, Jin HZ
…he need for routine TBI screening and preventive treatment. Trial registration Chinese Clinical Trial Registry, ChiCTR2100045823.
Zhenfan Wang, Xue Tian, Feng Yang, Lu Wang, Hao Li, et al.
…s under near-infrared imaging. The primary outcomes of this trial were the detection rate and background-tumour ratio of lung nodules, and the secondary objectives were time to search for nodules and operative time to nodules excision. RESULTS: A total of 50 pulmonary nodules in …
Chengyu Jiang, Xiaoqing Luo
…f-management may enhance treatment outcomes in patients. **TRIAL REGISTRATION:** Chinese Clinical Trial Registry, ChiCTR2500096661. Registered 27 January 2025; Retrospectively registered.
Xing XW, Zhang JT, Ma YB, He MW, Yao GE, et al.
…d in conjunction with conventional microbiological testing. Trial Registration: Chinese Clinical Trial Registry, ChiCTR1800020442.
Leon N, Balakrishna Y, Hohlfeld A, Odendaal WA, Schmidt BM, et al.
…ods We searched the Cochrane Central Register of Controlled Trials (CENTRAL) in the Cochrane Library, MEDLINE Ovid and Embase Ovid in May 2019. We searched Global Health, Ovid and PsycInfo in April 2016. In January 2020 we searched for grey literature in the Grey Literature Repor…
Foster N, Tadesse AW, McQuaid CF, Gosce L, Abdurhman T, et al.
…The ASCENT-Ethiopia study is a three-arm cluster randomised trial assessing two DATs with differentiated care for supporting tuberculosis treatment adherence in Ethiopia. This study is part of the ASCENT consortium, assessing DATs in South Africa, the Philippines, Ukraine, Tanzan…
Wekesa C, Sekaggya-Wiltshire C, Muyanja SZ, Lume I, Nabaggala MS, et al.
…nducting a non-inferiority open-label randomized controlled trial to compare adherence to MDR-TB treatment among patients on self-administered therapy (measured by Medication Events Monitoring System (MEMS) technology) with a control group on DOT. Methods We plan to enrol 164 new…
Tanue EA, Nsagha DS, Theophile NN, Assob JCN
…creasing use of this device. Objective The main aim of this trial is to assess whether sending weekly motivational text messages (SMS) through mobile phones versus no text messaging will improve retention in care and promote adherence to treatment and health outcomes among patien…
Murphy-Okpala N, Eze C, Ossai EN, Agu CI, Ezenwosu I, et al.
…ia and similar settings in low-and middle-income countries. Trial registration Pan African Clinical Trial Registry PACTR202309676675265.
Mahasha PW, Ndwandwe DE, Mavundza EJ, Shey M, Wiysonge CS
… of Mycobacterium bovis . Evidence from previous randomised trials show that the efficacy of primary BCG vaccination against pulmonary TB ranged from no protection to very high protection. In addition, some studies suggest a benefit of BCG revaccination. For example, a recent tri…
Nanyunja G, Kadota JL, Namale C, Hudson M, Nalugwa T, et al.
…l protection programs for eligible TB-affected individuals. Trial Registration: Pan African Clinical Trials Registry (PACTR201906852160014).
Pan M, Liu W, Zhang Z, Li T, Xie W
…, providing a reference for the rational use of ciprofol in clinical practice. Methods PTB patients who underwent bronchoscopy examination and treatment at The Third People's Hospital of Changzhou between May 2023 and June 2023 were selected and divided into four groups using a s…
Naomi Chapman, Vinícius Cavalheri, Elizabeth F. Smith, Jamie Wood, Luke W. Garratt, et al.
…utum. METHODS: This was a non-blinded randomised controlled trial where adults hospitalised with a CF exacerbation were allocated to an experimental intervention (EIx; MetaNeb) or a control intervention (CIx; their usual ACT). Both groups underwent twice-daily supervised airway c…
Mouquan Shen, Li Guo, Ya Li, Ruitong Gao, Xin Sui, et al.
…D ANALYSIS: We propose a single-blind randomized controlled trial using 75 hospitalized patients diagnosed with COPD with excessive sputum production. The patients will be divided into three groups. The intervention group will receive active cycle of breathing techniques combined…
Ying Hu, Zhiqiang Chen, Jing Zeng, Shouyan Zheng, Liujuan Sun, et al.
…lls to Tregs under certain conditions. However, no relevant clinical studies have been reported on the association between IDO activity and Th17/Treg imbalance in children with allergic asthma. The goal of this study was to test whether indoleamine 2,3 dioxygenase (IDO) participa…
Imran M, Khan SA, Asdaq SMB, Almehmadi M, Abdulaziz O, et al.
… antituberculosis agents. A few DprE1 inhibitors are in the clinical trial for tuberculosis (TB), including macozinone. This review highlights the discovery, developmental status, clinical studies, patents, and prospects of macozinone (MCZ). The patent and non-patent literature s…
Qian Lei, Hao Wang, Liyun Dang, Xiaohui Lv, Xuejiao Zhou, et al.
…in (RFP) in drug-susceptible TB patients, and to assess its clinical effectiveness and safety through a pragmatic randomized controlled trial (PRCT). **METHODS:** A total of 489 TB patients undergoing first-line anti-TB treatment were enrolled and randomly assigned to a pha…