Showing 101–125 of 200 documents
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World Health Organization. Regional Office for the Eastern Mediterranean
…illance networks in order to generate data necessary on new vaccines introduction is another important step. Tuberculosis notification and case detection rates can be improved through scaling up related collaboration between the public and private sectors, conducting active case …
Cristina Liscinscaia, Stela Kulcitkaia, Evelina Lesnic
Wide spreading of the drug resistance in the adult population makes the evolution of MDR-TB in children a challenge. The aim was to establish the peculiarities of the case-management in children diagnosed with MDR-TB in actual epidemiological conditions in R. Moldova (RM). It was…
Carolina Longo, Karina Felippe Monezi Pontes, Marina Matos de Moura Faíco, Mayra Martins Melo, Gustavo Yano Callado, et al.
Tuberculosis remains one of the leading infectious causes of morbidity and mortality worldwide, disproportionately affecting women of reproductive age, particularly in low- and middle-income countries. Tuberculosis during pregnancy represents a major clinical challenge, as physio…
Chatterjee S, Das P, Vassall A
…transfers. Alongside ensuring widespread access to COVID-19 vaccines, these policy actions remain pivotal in ensuring the well-being of those who are unfortunate enough to be living with tuberculosis.
Fassikaw Kebede, Tsehay Kebede, Birhanu Kebede, Belete Negese, Ayinalem Kebede
Background: Tuberculosis (TB) remains the first cause of death from infectious disease worldwide despite available effective therapies. In 2016, there were an estimated 10.4 million new cases of TB,490 000 new cases with multidrug-resistant TB (MDR-TB), and 1.7 million cases died…
Nur Qomariyah
Tuberculosis is an infectious disease with transmission through the air and droplets of infected people. The problem of spreading and treating tuberculosis needs some development. The model used in this study is a model of development, in which infected individuals are divided in…
Neil W. Schluger
The author focuses on data from patients who were exposed with tuberculosis (TB) treated with isoniazid (INH) according to Peruvian national guidelines in Peru Topics discussed include vaccine candidates in phase trials after cases of coronavirus disease (COVID-19), clinical tria…
Collin SM, Wurie F, Muzyamba MC, de Vries G, Lönnroth K, et al.
Aims What is the evidence base for the effectiveness of interventions to reduce tuberculosis (TB) incidence in countries which have low TB incidence? Methods We conducted a systematic review of interventions for TB control and prevention relevant to low TB incidence settings ( Re…
In this article, we propose a tuberculosis model with drug-sensitive (DS-TB) and multidrug-resistant (MDR-TB). The population is divided into 6 sub-population, namely susceptible (S), vaccinated (V), latent (E), active DS-TB (I s ), active MDR-TB (I r ), and recovered (R). There …
N.A. Smolianova, Natalia Lekontceva, А.Д. Никулин
…e immune response opens new horizons for the development of vaccines and more effective therapeutic approaches. For example, one of the survival strategies of this pathogen is the presence of multiple small regulatory RNAs (mRNAs) that form complex regulatory networks with mRNAs,…
Sahu S, Wandwalo E, Arinaminpathy N
The COVID-19 pandemic has set back the global tuberculosis (TB) response by several years. In 2020, access to TB prevention and care declined sharply, with TB notifications dropping by 18% compared to 2019. Declines were more pronounced in children, with a 24% drop in 0-14 year-o…
Anita Mansouri, Hind Bouguerra, Marouène Belkahla, Ahlem Gzara
Abstract Introduction Tuberculosis (TB) is a major cause of morbidity and mortality worldwide. In Tunisia, where TB remains endemic, the national control program ensures free vaccination, free outpatient TB treatment in addition to early detection of cases and directly observed t…
Mutayoba BK, Michael Hoelscher, Heinrich N, Joloba ML, Lyamuya E, et al.
Background Mycobacterium tuberculosis presents several lineages each with distinct characteristics of evolutionary status, transmissibility, drug resistance, host interaction, latency, and vaccine efficacy. Whole genome sequencing (WGS) has emerged as a new diagnostic tool to rel…
Safae Elfirdaous Fari, M. Maamar, Khibri Haja, Nisserine Jait, Y. Moussadik, et al.
<i>Introduction: </i>Tuberculosis (TB) is a pathology considered one of the main causes of death by single infectious agent, ranking just after HIV / AIDS. Indeed, its emergence and the difficulty of its treatment, especially in the resistant form, in patients with co-infection w…
Harshada R Bandgar
Tuberculosis or TB caused by the micro-organism Mycobacterium tuberculosis is a highly contagious and the second most fatal disease after AIDS. It is estimated that it will soon surpass the deaths caused by HIV.BCG is the only vaccine available to prevent TB, however it is not ef…
L.D. Todoriko
Ukraine remains one of the leaders in the global ranking of morbidity and mortality from tuberculosis (TB) and, according to WHO, ranks 5th in the world and 2nd in Europe according to these indicators. Objective — to analyze the regional features of the epidemiology of tuberculos…
Vineet Bhatia, Mukta Sharma, Suman Rijal
…d to be prepared for investments in adoption and rollout of vaccines for TB as and when these are available in near future. Overall, the current funding levels will need to be trebled. There is also a need for introducing efficiencies through integrated, primary healthcare approa…
Muhammad Khurram, Rida Khalid, Safia Ehsan, Muqdas Fatima, Azka Hafiza, et al.
Mycobacterium tuberculosis, a gram-positive bacterium that causes tuberculosis (TB) in human is still a serious global health concern, especially in Asia where 22 high burden countries are responsible for 80% of the world's TB cases.There are more than 150 known species of M. tub…
S. van der Niet
Pathogenic microbes are a major health concern, killing millions of people worldwide every year including 1.6 million by <i>Mycobacterium tuberculosis</i>. Despite decades of tuberculosis research, there is still no effective treatment or vaccine available and due to increased in…
Yiheyis Genetu, Bethelhem Belay, Workeabeba Abebe
Background: Approximately 81% of all childhood tuberculosis cases occur among 22 high-burden countries and Ethiopia ranks eighth among these high burden countries. The GeneXpert Mycobacterium tuberculosis DNA and resistance to rifampicin (MTB/RIF) test can detect pediatric tuberc…
Berube BJ, Larsen SE, McNeil MB, Reese VA, Pecor T, et al.
…or advancing and screening next generation therapeutics and vaccines, we aimed to design preclinical DR models of Beijing lineage M.tb HN878 strain in different mouse backgrounds. We found escalating sensitivities of morbidity due to low dose aerosol challenge (50-100 bacilli) in…
Vikas Jha
Tuberculosis is still a serious, life-threatening disease all throughout the world. One of the greatest therapeutic challenges is the treatment of multidrug-resistant tuberculosis. The prevalence of multidrug resistant tuberculosis (MDR-TB) poses a danger to the ability of conven…
JaiPrakash Narain, Natasha Dawa, Olavi Elo
…ssential diagnostic technologies, life-saving medicines and vaccines in border areas. Education and information services, along with enhanced connectivity along and across borders, will help a great deal in building and strengthening core capacities in disease surveillance and re…
Kashif Bashir, Muhammad Amir, Muhammad Idrees, Muhammad Ajmal Khan, Sajjad Ali, et al.
GeneXpert MTB/RIF is a molecular technique for the diagnosis of tuberculosis. This method not only detects M. tuberculosis but also identifies the absence or presence of different drug resistant mutations in DNA fragments like rifampicin resistance. In this study, about 200 septu…
M.I. Sakhelashvili, O.P. Kostyk, O.I. Sakhelashvili–Bil, Z.I. Piskur, J.J. Didyk
Objective — to study the peculiarities of the resistance of M. tuberculosis (MTB) to antimycobacterial drugs (AMBD) among children and adolescents living in multidrug-resistant tuberculous focies.
 Materials and methods. 246 children were examined, 145 of them had drug-resi…