Showing 101–125 of 200 documents
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Jemal Hussein, MD, Peter Bang, Msc
The study has the following objectives: Primary objective To evaluate the safety profile of an adjuvanted TB subunit vaccine administered in different antigen/adjuvant formulations at 0 and 2 months Secondary objective To determine the immunogenicity profile of an adjuvanted TB …
Yun Xu, Xiaochun Wang, Qiangsen Zhong
Bacillus Calmette-Guérin (BCG) is the only vaccine currently used in clinical practice to prevent tuberculosis (TB), however, it remains limited in preventing latent infection, TB reactivation, and providing comprehensive protection. In this study, the pcaA gene, an antigen …
Qiangsen Zhong, Xiaochun Wang, Yun Xu, Runlin Wang, Mingming Zhou, et al.
…lopment of novel TB diagnostic tools and next-generation TB vaccines with important clinical translational prospects.
Hino Y, Eshima N, Tokumaru O, Bacal K, Tanaka Y, et al.
Background A change in the timing of the Bacillus Calmette-Guérin (BCG) vaccination among infants in Japan appears to be associated with an increase in the incidence rate of latent tuberculosis infection (LTBI). Methods Data on both active and latent tuberculosis (TB) infections …
Achkar JM, Prados-Rosales R
A more effective vaccine to control tuberculosis (TB), a major global public health problem, is urgently needed. Current vaccine candidates focus predominantly on eliciting cell-mediated immunity but other arms of the immune system also contribute to protection against TB. We rev…
Druszczynska M, Seweryn M, Wawrocki S, Pankowska A, Kulbachko A, et al.
Background Accurate diagnosis of tuberculosis (TB) in children continues to be challenging, primarily due to the low bacterial load characteristic of the disease and the obstacles in collecting sputum samples. Furthermore, detecting cases of latent Mycobacterium tuberculosis (M.t…
Trollfors B, Sigurdsson V, Dahlgren-Aronsson A
Objectives This study aimed to determine the prevalence of latent tuberculosis infection (LTBI) in immigrant children and adolescents (aged 0-17 years) living or recently arriving in Sweden. It also aimed to estimate the effectiveness of Bacillus Calmette-Guérin (BCG) against LTB…
Erol S, Ciftci FA, Ciledag A, Kaya A, Kumbasar OO
Purpose Immunocompromised patients with latent tuberculosis infection (LTBI) are at high risk of progression to active tuberculosis. Detection and treatment of LTBI in this group of patients are very important to control active tuberculosis. Tuberculin skin test (TST) and interfe…
Yang QY, Zhang YT, Xiao JN, Liang YS, Ji P, et al.
Long-term immunoreactivity to mycobacterial antigens in Bovis Calmette-Guérin (BCG)-vaccinated population is not well investigated. Herein, 361 volunteer healthy donors (HDs) with neonatal BCG vaccination from Shanghai region (China) were enrolled. They were subdivided into ESAT-…
Guo X, Lu J, Li J, Du W, Shen X, et al.
…ug therapy is needed, which has many drawbacks. At present, vaccines are proposed as an adjunct to chemotherapy to protect populations with an LTBI and delay its recurrence. In this study, we analyzed the protective effect of a novel subunit vaccine, AEC/BC02, in a guinea pig lat…
Carreras-Abad C, Oliveira-Souto I, Pou-Ciruelo D, Pujol-Morro JM, Soler-Palacín P, et al.
Background Unaccompanied and separated children (UASC) are a high-risk group for infectious diseases and information on their vaccination status is scarce. Different approaches are used to screen newly arrived minors in Europe. The aim of this study was to describe the health sta…
Lu J, Guo X, Wang C, Du W, Shen X, et al.
…sitating the development of further TB drugs or therapeutic vaccines. Herein, we evaluated the therapeutic effect of a novel subunit vaccine AEC/BC02 after chemotherapy in a spontaneous Mtb relapse model. Immunotherapy followed 4 weeks of treatment with isoniazid and rifapentine,…
Samer Singh
ABSTRACT The reason for the observed country-wise variability in incidence and severity of the COVID-19 outcome remains unknown. Few recent studies have suggested a positive protective correlation of the BCG vaccination policy of the countries with the observed COVID-19 severity.…
Zhao HM, Du R, Li CL, Ji P, Li HC, et al.
…s of Mtb-infected populations or development of therapeutic vaccines against tuberculosis (TB). Among them, Rv2028c is a dormancy-related antigen that has demonstrated potential use in TB control, but its immunological characteristics in the BCG-vaccinated Chinese population are …
Qian Jiang, Zhijun Liu, Lianwen Wang, Ronghua Tan
Screening those individuals who are latent but at higher risk of rapidly developing active tuberculosis (TB) is one of the intervention measures to control the spread of TB. This work proposes a TB SVELIT (S‐Susceptible, V‐Vaccinated, E‐Early latent, L‐Late latent, I‐Infected, T‐…
Yadav J, Phogat S, Chaudhary D, Jaiwal R, Jaiwal PK
Objectives The only approved vaccine, Bacillus Calmette Guérin (BCG) used in global tuberculosis (TB) immunization programmes has been very effective in childhood TB but not in adult pulmonary and latent TB. Moreover, the emergence of multi-drug resistance-TB cases demands either…
Malherbe ST, Kleynhans L, Walzl G
The development of an improved vaccine to stimulate an effective response against Mycobacterium tuberculosis (MTB) infection and disease will be a major breakthrough in the fight against TB. A lack of tools to adequately track the progression or resolution of events in TB pathoge…
Huang W, Fang Z, Luo S, Lin S, Xu L, et al.
Objectives In this study, we aimed to verify whether Bacillus Calmette-Guérin (BCG) can protect first-year college students against Mycobacterium tuberculosis (MTB) infection by the recombinant fusion protein ESAT6-CFP10 skin test (ECST) or the tuberculin skin test (TST). Methods…
Goscé L, Bitencourt J, Gupta RK, Arruda S, Rodrigues LC, et al.
Despite much progress globally, TB is still one of the top 10 causes of death worldwide. Several studies have shown the importance of implementing different preventive strategies alongside treatment of TB disease, including BCG vaccination and treatment of latent tuberculosis inf…
Socorro Miranda-Hernandez, Manoharan Kumar, Alec Henderson, Erin Graham, Xiao Tan, et al.
About two billion people are latently infected with Mycobacterium tuberculosis (Mtb), which can reside in multiple organs, including the lymphatics. The risk of latent Mtb infection (LTBI) reactivation increases with immunosuppression, such as HIV coinfection, yet the immunologic…
Yuan Tian, Mingming Zhang, Syed Luqman Ali, Aigul Abduldayeva, Shuang Zhou, et al.
: Latent tuberculosis infection (LTBI) is the principal reservoir for active tuberculosis, with >85% of cases attributable to reactivation. Bacillus Calmette-Guérin fails to block this transition, leaving a critical gap in prevention.: An immunoinformatics/reverse-vaccinolog…
Silver RF, Xia M, Storer CE, Jarvela JR, Moyer MC, et al.
Tuberculosis remains an international health threat partly because of limited protection from pulmonary tuberculosis provided by standard intradermal vaccination with Bacillus of Calmette and Guérin (BCG); this may reflect the inability of intradermal vaccination to optimally ind…
Kendra Brett, Melissa Severn

 In people who have been vaccinated with Bacillus Calmette-Guérin, the interferon gamma release assay appears to be related to fewer diagnoses for latent tuberculosis infection, fewer prescriptions of preventive tuberculosis therapy, and no difference in the number of activ…
Socorro Miranda‐Hernandez, Manoharan Kumar, Alec Henderson, Erin Graham, Xiao Tan, et al.
Abstract It is estimated that two billion people are latently infected with Mycobacterium tuberculosis ( Mtb ), the causative agent of tuberculosis (TB). Latent Mtb infection (LTBI) can occur in multiple organs, including the lymphatics. The risk of LTBI reactivation increases in…
Dilber Ademhan Tural, Deniz Doğru, Beste Özsezen, Azer Karaman, Birce Sunman, et al.
**UNLABELLED:** Tumor necrosis factor-alpha (TNF-α) inhibitors increase the risk of developing active tuberculosis (TB) disease through reactivation of latent TB infection (LTBI). We aimed to analyze TB infections in BCG-vaccinated children and adolescents with rheumatologi…