Showing 101–125 of 200 documents
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Theresa Musa Hassab, Audrey Hamachila, Aubrey Chichonyi Kalungia, Norman Nyazema, Moses Mukosha, et al.
Tuberculosis (TB) and HIV co-infection pose significant challenges in resource-limited settings, contributing to multi-drug-resistant TB when treatment fails. This study aimed to identify determinants of TB treatment outcomes among HIV/TB co-infected patients in Lusaka, Zambia.A …
World Health Organization
Jessica F Magidson, PhD, Bronwyn J Myers, PhD
Poor engagement in care contributes to HIV- and TB-related morbidity and mortality in South Africa (SA). Community health workers (CHWs) are frontline lay health workers who work to re-engage patients who are lost to follow-up (LTFU) in HIV/TB care. Patients with depression and s…
Galyna kutsyna, MD, PhD
Dzherelo (Immunoxel) is an oral immunomodulating botanical agent available over-the-counter in Ukraine. After many years of laboratory and clinical testing the formulation was approved in 1997 by the Ministry of Health of Ukraine as a dietary herbal supplement, which enhances imm…
World Health Organization
Lungu P, Mushota K, Njelesani E, Sukwa T, Lakhi S, et al.
Background Mycobacterium tuberculosis (TB) remains a disease of global health concern and a leading cause of mortality arising from an infectious agent. Protective immunity to TB remains unclear. Suppressor of cytokine signaling-3 (SOCS3) and signal transduction and activator of …
Anthony D. Harries, PhD, Huy Dung Nguyen, MD
The overall aim of the project is to evaluate rifabutin (RBT) as a replacement for rifampicin (RMP), for the combined treatment of tuberculosis and HIV infection. RBT represents an alternative to RMP for HIV infected patients as its half-life is longer and the enzymatic induction…
World Health Organization
Lisa Puchalski Ritchie
Despite increased emphasis on evidence based practice in recent years a gap remains between evidence and practice, particularly in resource poor countries. Few studies to date have examined the use of knowledge translation strategies to improve health care outcomes in low income …
Mamadou Sow, Alioune Camara, Sidikiba Sidibé, Ibrahima Kaba, Nestor Niouma Leno, et al.
Introduction: The aim was to assess weight gain during tuberculosis treatment in patients co-infected with tuberculosis and HIV. Methods: Tuberculosis patients co-infected with HIV and undergoing tuberculosis treatment in the pneumophtisiology and infectious and tropical diseases…
Anthony D Harries, MD, PhD, Alexander PYM, MD
The overall aim of the project is to evaluate rifabutin (RBT) as a replacement for rifampicin (RMP), for the combined treatment of tuberculosis and HIV infection. RBT represents an alternative to RMP for HIV infected patients as its half-life is longer and the enzymatic induction…
Dmytro Butov, MD
Treatment of multidrug-resistant TB (MDR-TB) is 100 times more expensive than treatment of drug-susceptible TB, requiring intensive clinical management for prolonged time (18-24 months) and more toxic treatment course. In prior open label study the investigators have shown that a…
Nyagosya Range, MSc, PhD, Henrik Friis, MD, PhD
We propose a randomised trial among pulmonary TB patients, examined and treated as part of the national TB control programme (WHO, 2003). The aim is to improve TB treatment outcome in high TB and HIV burden countries. The overall objective of the proposed trial is to assess the e…
Jinhong He, Xiangxi He, Xiaoxin Xie, Yanhua Fu, Xingxing Luo, et al.
Introduction Co-infection with tuberculosis (TB) is the leading cause of death in individuals infected with human immunodeficiency virus (HIV)-1. Dolutegravir and lamivudine (DTG+3TC) has recently been recommended as the preferred first-line regimen for the treatment of new and t…
Gengiah S, Connolly C, Yende-Zuma N, Barker PM, Nunn AJ, et al.
Background A quality improvement (QI) collaborative approach to enhancing integrated HIV-Tuberculosis (TB) services may be effective in scaling up and improving the quality of service delivery. Little is known of the role of organizational contextual factors (OCFs) in influencing…
World Health Organization
UNAIDS, PEPFAR, World Health Organization, World Health Organization
World Health Organization
Bionghi N, Daftary A, Maharaj B, Msibi Z, Amico KR, et al.
…e-containing TB regimens. Methods Eligible patients were DR-TB/HIV co-infected adults hospitalized for the initiation of Bedaquiline-containing treatment regimens in KwaZulu-Natal, South Africa. A one-way crossover design was used to evaluate levels of adherence and patient accep…
World Health Organization, UNAIDS, Global Fund to Fight AIDS, Tuberculosis and Malaria, United Nations Children's Fund (UNICEF)
World Health Organization
Saavedra Cervera B, López MG, Chiner-Oms Á, García AM, Cancino-Muñoz I, et al.
Genomic studies of the Mycobacterium tuberculosis complex (MTBC) might shed light on the dynamics of its transmission, especially in high-burden settings, where recent outbreaks are embedded in the complex natural history of the disease. To this end, we conducted a 1 year prospec…
Tesfaye B, Alebel A, Gebrie A, Zegeye A, Tesema C, et al.
Background Tuberculosis and HIV/AIDS are the major public health problems in many parts of the world particularly in resource limited countries like Ethiopia. Although studies have been conducted on the prevalence and associated factors of TB / HIV co-infection in Ethiopia, there…
World Health Organization
World Health Organization