Showing 101–125 of 200 documents
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Anchalee Avihingsanon, MD, PhD
…. The study will also assess safety and tolerability of the regimens, adherence to the treatments, and patterns of antibiotic resistance among Mycobacterium tuberculosis (MTB) isolates in participants who fail on these prophylactic regimens. Under this study, there is one substu…
Amirtha Gopalan, Meghna Gavali, Keerthivardhan Yerram
… in high TB-burden settings. 3,4Short-course rifamycinbased regimens are prioritized globally to maximize treatment completion and safety, factors that are paramount in managing chronic inflammatory diseases.While international guidelines often cite rifapentinebased regimens (suc…
Anita Uka, Frédéric Méchaï, Daniela Maria Cirillo, Lorenzo Guglielmetti, Yousra Kherabi, et al.
…tion, use of microbiological and molecular tests, treatment regimens for active and latent TB, monitoring practices, and adherence to international (WHO 2022, ERS/ECDC 2017 and IJTLD 2023) guidelines. Descriptive analyses were performed to summarize practices and identify variabi…
L Ye, M Chen, Xiang Gao, Kaichun Wu, Zhi Hua Ran, et al.
…e the optimal prophylactic anti-TB strategies and treatment regimens in Chinese IBD subjects receiving IFX treatment. IBD patients receiving IFX at 18 academic hospitals in China were enrolled. Incidence and risk factors for active TB during IFX treatment were studied. The incide…
Mary C White, PhD
…e of this project is to evaluate the effect of two accepted regimens for treating latent tuberculosis infection (LTBI) in jail. Tuberculosis (TB) in incarcerated populations continues to be a serious problem, due to the large proportion of persons who are at high risk of both hav…
Bijan J. Ghassemieh, Masahiro Narita
…ury and a low rate of treatment completion. Rifamycin-based regimens (3 months of once weekly INH and rifapentine, 4 months of daily rifampin, and 3 months of daily INH and rifampin) are now preferred because of their effectiveness, safety, and high treatment completion rates. Pr…
О. Д. Баронова, Valentina Aksenova, E. F. Luginova, E. N. Dolzhenko
…f children with latent tuberculosis infection using various regimens of anti-tuberculosis drugs and assess the risk of adverse events to these drugs. Subjects and Methods . 117 children of 2-17 years old with latent tuberculosis infection [a positive result of the test with tuber…
Caruso E, Mangan JM, Maiuri A, Bouwkamp B, DeLuca N
…eported prescribing recommended short-course LTBI treatment regimens, and 4.0% reported doing none of the treatment practices available for patients with LTBI (i.e., prescribing short-course regimens, longer course regimens, or referring patients to a health department). Further …
Beatriz Caroline Soares Chaves, Ana Carolina Souza, Janaína Leung, Walter Costa, Ana Paula Santos
…uppressant (83.5%) and HIV infection (5.2%). The prescribed regimens were as follows: H for 73.5% of patients, HP for 17.9%, and Rifampicin (R) for 8.6%. The 247 known outcomes were compared based on the regimens used. Among patients who used H, 20% were lost to follow-up vs. 4.8…
Oh CE, Menzies D
…Korean guidelines for TB published in 2020 recommend 2 LTBI regimens for children and adolescents: 9 months of daily isoniazid (9H) and 3 months of daily isoniazid plus rifampicin. Isoniazid for 6-12 months has been used to effectively treat LTBI in children for over 50 years. Ho…
Gabriela Pizarro Ossa Ferro Henriques, Aline Barbosa Scarabelli, Vanessa Santos de Paula, Elaine Aparecida Fernandes de Oliveira
…ed in 2021, with efficacy similar to previously established regimens and advantages such as higher treatment completion rates and safety. Adverse events (AEs) associated with 3HP are mostly mild and self-limited. Flu-like syndrome and other systemic hypersensitivity reactions are…
Anjana Dogra, Sheetal Agarwal
…tudies focusing on molecular diagnostics, drug-resistant TB regimens and TB preventive treatment (TPT). Results: Rapid molecular diagnostics such as Xpert MTB/RIF, Truenat assays, Xpert MTB/XDR and line probe assays allow early detection of TB and drug resistance. Use of less inv…
Lilian Tran, Anand Shah, Eugene J Kim, Sofia Lopiano, Isabella N Blanchard, et al.
…eatment (2016-2024). Demographics, comorbidities, treatment regimens, and outcomes were collected by chart review. LTBI was diagnosed by physician documentation or positive Interferon-Gamma Release Assays (IGRAs). CLD etiologies included NAFLD, alcohol-associated liver disease, c…
Lee J, Kim D, Hwang J, Kwon JW
…rence to diverse tuberculosis (TB) preventive therapy (TPT) regimens on TB risk in individuals with TB infections (TBIs). This study aimed to examine the association between adherence to three TPT regimens and TB incidence. Methods This population-based retrospective cohort study…
World Health Organization
…dresses the use of preferred and alternative antiretroviral regimens across different populations, including adults, adolescents, pregnant women and children, with emphasis on treatment efficacy, safety, adherence and feasibility in low- and middle-income countries. The guidelin…
World Health Organization
…erapy (ART), second-line treatment strategies, dual-therapy regimens (oral and injectable), prevention of vertical HIV transmission, breastfeeding support and tuberculosis preventive treatment in people living with HIV. Dolutegravir-based regimens remain highly effective for seco…
Andrey S Borisov, MD, MPH, Robert Belknap, MD, Robert Belknap, MD
The study is an open label, multicenter, randomized (three arms: DOT (standard control), SAT, SAT with SMS reminders) controlled clinical trial. The trial is conducted in patients diagnosed with latent tuberculosis infection (LTBI) who are recommended for treatment. The primary o…
Dereck Tait, MD, Angelique Luabeya, MD
…e study will be expanded to evaluate both 2-dose and 3-dose regimens and to include LTBI(+) subjects. In the first phase, 50 LTBI(-) subjects will be enrolled in Group 1 and randomized at a ratio of 3:3:3:1 to receive 2 doses of 5/500, 15/500, or 50/500 of AERAS-456, or placebo g…
Bastos ML, Campbell JR, Oxlade O, Adjobimey M, Trajman A, et al.
Background Four months of rifampin treatment for latent tuberculosis infection is safer, has superior treatment completion rates, and is as effective as 9 months of isoniazid. However, daily medication costs are higher for a 4-month rifampin regimen than a 9-month isoniazid regim…
Chen H, Zhang H, Cheng J, Sun D, Wang Q, et al.
…nce to TPT can be enhanced through shorter, safer treatment regimens and supportive interventions, such as directly supervised therapy for TPT recipients and incentives for healthcare providers managing TPT.
Singh P, Moulton LH, Barnes GL, Gupta A, Msandiwa R, et al.
…ican women with HIV enrolled in a randomized trial of 4 TPT regimens (two 3-month regimens, rifapentine/isoniazid [3HP] or rifampin/isoniazid [3HR], isoniazid for 6 months, or isoniazid continuously). Descriptive statistics and risk ratios were assessed to examine relationships b…
Chevrier C, Diaz MH, Rueda ZV, Balakumar S, Haworth-Brockman M, et al.
…tcomes since the introduction of two short-course treatment regimens: 4-months of rifampin, and 3-months of isoniazid and rifapentine. Methods This study combined a retrospective analysis of program administrative data with structured interviews of clinic staff. We included LTBI …
Sarah O’Donnell, Gloria Leonardi, Federica Piedepalumbo, Maurizio Ferrarese, Alice Claudia Repossi, et al.
… patients undergoing the three most commonly used treatment regimens. <b>Methods:</b> This single centre, retrospective, observational, cohort study enrolled patients affected by LTBI referring to Villa Marelli outpatient clinic from 1992 to 2022. Treatment regimen, reported AEs …
Gloria Leonardi, Sarah O’Donnell, Federica Piedepalumbo, Maurizio Ferrarese, Alice Claudia Repossi, et al.
… of the patients requiring LTBI screening and the treatment regimens. <b>Methods:</b> This retrospective, observational, cohort study enrolled patients referring to Villa Marelli outpatient clinic during the last 15 years. LTBI status, underlying medical conditions leading to scr…
Gonzalo G Alvarez, MD
This phase IV clinical study trial will be conducted among persons who require treatment for LTBI treatment in Iqaluit, Nunavut and Ottawa, Ontario. The primary objective of this study is to compare the proportion of people who complete directly observed prophylactic treatment (D…