Showing 101–125 of 200 documents
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I. Zhanybekov
The article presents a comparative analysis of the medical, social and clinical and epidemiological characteristics of patients with tuberculosis, the causative agent of which has broad (XDR-TB) and pre-wide (pre-XDR-TB) drug resistance in the Kyrgyz Republic. The study included …
Hemali Savla, Bhushan S. Bhale, Nisha Sharma, Pradnya R. Petkar
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is a major public health problem affecting millions of people worldwide. The emergence of multidrug-resistant (MDR) and extremely drug-resistant (XDR) strains of Mtb has further increased the disease-related mortality…
Popovici O, Monk P, Chemtob D, Chiotan D, Freidlin PJ, et al.
Extensively drug-resistant (XDR) tuberculosis (TB) poses a threat to public health due to its complicated, expensive and often unsuccessful treatment. A cluster of three XDR TB cases was detected among foreign medical students of a Romanian university. The contact investigations …
Erick Manuel Delgado Moya
In this work, we propose a new mathematical model for the study of the effectiveness of TB treatment taking into account the vulnerable subpopulations, HIV/AIDS and diabetic patients. Our model studies the different types of treatment resistance, multidrug-resistant (MDR-TB) and …
Erick Manuel Delgado Moya
In this work, we propose a new mathematical model for the study of the effectiveness of TB treatment taking into account the vulnerable subpopulations, HIV/AIDS and diabetic patients. Our model studies the different types of treatment resistance, multidrug-resistant (MDR TB) and …
Erick Manuel Delgado Moya, Alain Piétrus, Sergio Oliva
…ensively drug-resistant (XDR-TB). The main mathematical and epidemiology features of the model are investigated. The basic reproduction number (R0) in the different sub-populations (diabetics, HIV/AIDS, and those who do not suffer from these diseases) was studied. Conditions were…
World Health Organization. Regional Office for Europe
This document summarizes tuberculosis country work in 12 Member States of the WHO European Region. It includes epidemiological profiles, describes major challenges these countries are facing, achievements made in collaboration with WHO and planned WHO activities, and presents a l…
Nelson KN, Gandhi NR, Mathema B, Lopman BA, Brust JCM, et al.
Patterns of transmission of drug-resistant tuberculosis (TB) remain poorly understood, despite over half a million incident cases worldwide in 2017. Modeling TB transmission networks can provide insight into drivers of transmission, but incomplete sampling of TB cases can pose ch…
Yang S, Xia C, Zheng X, Lu Y, Deng J, et al.
Sen Yang,1,* Chao Xia,1,* Xiaoman Zheng,1 Yanqiu Lu,1 Jiaoyu Deng,2 Yaokai Chen1 1Clinical Research Center, Chongqing Public Health Medical Center, Chongqing, People’s Republic of China; 2Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virolo…
Dhruv Gandhi, Viren Amesur, Minnie Bodhanwala, Ira Shah
Abstract Background Pediatric central nervous system tuberculosis (CNS-TB) accounts for 10% of all pediatric TB cases in India and carries the highest morbidity and mortality. However, data on pediatric drug resistant (DR) CNS-TB remains scarce. Regional data from Mumbai suggests…
Yang,Sen, Xia,Chao, Zheng,Xiaoman, Lu,Yanqiu, Deng,Jiaoyu, et al.
Sen Yang,1,* Chao Xia,1,* Xiaoman Zheng,1 Yanqiu Lu,1 Jiaoyu Deng,2 Yaokai Chen1 1Clinical Research Center, Chongqing Public Health Medical Center, Chongqing, Peopleâs Republic of China; 2Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Viro…
Yao Chen, Xiaomeng Zhang, Qunying Hong, Weili Lin
… morbidity due to multiply factors from clinical treatment, epidemiology and compliance of patients including drug abusing, irregular schedules and gene mutations. Therefore, we present a case of TB with rifampin-resistance in this article to explore risk factors of drug-resistan…
Leningrad Oblast Regional Anti-Tuberculosis Dispensary, Slantsy, Slantsevsky District, Leningrad Oblast, Russia, N.A. Barmina, Yu.V. Korneev, Leningrad Oblast Regional Anti-Tuberculosis Dispensary, Slantsy, Slantsevsky District, Leningrad Oblast, Russia
The epidemiological situation of tuberculosis (TB) has been improving steadily in recent years however, in the structure of TB patients, there is a high proportion of patients with multidrugresistant/extensively drug-resistant (XDR) pathogens and people with HIV and TB co-infecti…
Terry E. Robinson, Jane Scullion
…facts about tuberculosis (TB), then goes on to describe the epidemiology and pathophysiology of the disease. Risk factors, and signs and symptoms, and investigations are all covered. The treatment phase and standard drug therapies are shown, and directly observed therapy for the …
Vyazovaya A, Proshina E, Gerasimova A, Avadenii I, Solovieva N, et al.
…ost and Mycobacterium tuberculosis. We hypothesized that TB epidemiology in the rural regions in the Soviet Union was impacted by construction of the Gulag camps and significant incoming migration. This molecular M. tuberculosis study was conducted in 2017 in the Komi Republic in…
World Health Organization. Regional Office for Europe
This document summarizes tuberculosis country work in 17 Member States of the WHO European Region. It includes epidemiological profiles, describes major challenges these countries are facing, achievements made in collaboration with WHO and other partners, and planned WHO activiti…
Salvato RS, Costa ERD, Reis AJ, Schiefelbein SH, Halon ML, et al.
Drug-resistant tuberculosis (DR-TB) is major problem in the fight against TB. Multidrug resistant (MDR) TB patients have a reduced treatment success rates and for, extensively drug-resistant (XDR) TB the cure rate does not exceed 25% in many countries. To evaluate the pre-XDR-TB …
World Health Organization. Regional Office for South-East Asia
The attached working paper highlights the most significant and relevant decisions and resolutions emanating from the Sixty-second World Health Assembly (held from 16-20 May 2009) as well as the 124th and 125th Sessions of the Executive Board (held from 19-27 January 2009 and on 2…
Qureshi H, Shah Z, Raja MAZ, Alshahrani MY, Khan WA, et al.
Tuberculosis (T.B.) remains a prominent global cause of health challenges and death, exacerbated by drug-resistant strains such as multidrug-resistant tuberculosis MDR-TB and extensively drug-resistant tuberculosis XDR-TB. For an effective disease management strategy, it is cruci…
Dong J, Cheng Q, Tang C, Zhong Y, Wang J, et al.
Oxazolidinones, novel synthetic antibacterials, inhibit protein biosynthesis and show potent activity against Gram-positive bacteria, including Mycobacterium tuberculosis (MTB). In this study, we aimed to compare the in vitro activity of linezolid (LZD) and four oxazolidinones, i…
Sun Q, Yan J, Long S, Shi Y, Jiang G, et al.
Introduction. Aminoglycoside antibiotics such as amikacin and kanamycin are important components in the treatment of Mycobacterium tuberculosis (Mtb) infection. However, more and more clinical strains are found to be aminoglycoside antibiotic-resistant. Apramycin is another kind …
Swinkels HM, Jilani TN, Tobin EH
Tuberculosis (TB) is a preventable and, in most cases, curable disease. Nonetheless, it remains a formidable public health challenge, killing more than 1.25 million people in 2023. The world's most prevalent human infection, it has affected humans across millennia and killed more…
Zhang SX, Miao FY, Yang J, Zhou WT, Lv S, et al.
Background Tuberculosis (TB) is a major infectious disease with significant public health implications. Its widespread transmission, prolonged treatment duration, notable side effects, and high mortality rate pose severe challenges. This study examines the epidemiological charact…
Dorji T, Tshering K, Adhikari L, Jamtsho T, Bhujel P, et al.
Objectives The emergence of multidrug-resistant tuberculosis (MDR-TB) has made the elimination of TB difficult. Currently, there are limited data on MDR-TB and other drug-resistant TB in Bhutan. We aimed to estimate the incidence and explore the potential risk factors associated …
Daniyarov A, Akhmetova A, Rakhimova S, Abilova Z, Yerezhepov D, et al.
…rgeted prevention and control strategies based on the local epidemiology of tuberculosis. Furthermore, the data obtained from whole-genome sequencing can help in tracing the transmission pathways of tuberculosis and facilitating early detection of outbreaks. Conclusions The resul…