Showing 101–125 of 200 documents
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Conceição EC, Salvato RS, Gomes KM, Guimarães AEDS, da Conceição ML, et al.
Molecular-typing can help in unraveling epidemiological scenarios and improvement for disease control strategies. A literature review of Mycobacterium tuberculosis transmission in Brazil through genotyping on 56 studies published from 1996-2019 was performed. The clustering rate …
Yanping Liu, Yangyi Zhang, Xiaoyu Lu, Zheyuan Wu, Minjuan Li, et al.
Mixed infection refers to the presence of multiplestrains within one host, while heteroresistance denotes the coexistence of drug-susceptible and drug-resistant strains or genotypes. Mixed infections and heteroresistance withcan complicate drug resistance diagnosis, treatment opt…
Emilyn Costa Conceição, Karla Valéria Batista Lima, Cristiane Cunha Frota, Theolis Costa Barbosa Bessa, Adriana Ayden Ferreira, et al.
Globally, tuberculosis (TB) remains a top cause of death from infectious diseases, with an estimated 1.5 million deaths annually. Given its substantial social and economic burden, TB is a priority in the United Nations 2030 Agenda for Sustainable Development. The WHO's End TB Str…
Shamebo T, Gumi B, Zewude A, Gashaw F, Mohammed T, et al.
…he objective of this study was to investigate the molecular epidemiology and drug sensitivity of Mycobacterium tuberculosis (M. tuberculosis) isolated from homeless individuals in Addis Ababa, Ethiopia. The study was conducted on 59 M. tuberculosis isolates, which were recovered …
Gangabhavani Pothuraju, Sk. Iaefath Naaz, Dr. Bushra, Syed Touseef Banu
Background: Multidrug-resistant tuberculosis (MDR-TB) remains a public health concern, particularly in resource-constrained settings. Limited data exist on the regional burden and epidemiological patterns of MDR-TB in Vikarabad district, Telangana, India. This study was conducted…
Yang S, Yu Y, Ji Y, Luo DJ, Zhang ZY, et al.
Tuberculosis (TB) is the leading cause of death among infectious diseases. China has a high burden of TB and accounted for almost 13% of the world's cases of multi-drug resistant (MDR) TB. Spinal TB is one reason for the resurgence of TB in China. Few large case studies of MDR sp…
Mtetwa HN, Amoah ID, Kumari S, Bux F, Reddy P
… underreporting. This study proposes using Wastewater-Based Epidemiology (WBE) to monitor DR-TB in six African countries (Ghana, Nigeria, Kenya, Uganda, Cameroon, and South Africa) and examines the impact of treated wastewater on the spread of TB drug-resistant genes in the envir…
Yin J, Zhang H, Gao Z, Jiang H, Qin L, et al.
Background Understanding multidrug-resistant tuberculosis (MDR-TB) transmission patterns is crucial for controlling the disease. We aimed to identify high-risk populations and geographic settings of MDR-TB transmission. Methods We conducted a population-based retrospective study …
Goig GA, Menardo F, Salaam-Dreyer Z, Dippenaar A, Streicher EM, et al.
Background Experimental data show that drug-resistance-conferring mutations are often associated with a decrease in the replicative fitness of bacteria in vitro, and that this fitness cost can be mitigated by compensatory mutations; however, the role of compensatory evolution in …
Xu Z, Liu H, Liu Y, Tang Y, Tan Y, et al.
Background Tuberculosis (TB) seriously threatens individual and public health. Recently, TB outbreaks in schools have been reported more frequently in China and have attracted widespread attention. We reported three TB outbreaks in high schools in Hunan Province, China. Methods W…
Thomsen J, Abdulrazzaq NM, Nyasulu PS, Al Hosani F, Habous M, et al.
… from the Middle East and North Africa (MENA) region on the epidemiology and antimicrobial resistance trends of TB, including MDR-TB remains scarce. Methods A retrospective 12-year analysis of N = 8,086 non-duplicate diagnostic Mycobacterium tuberculosis complex (MTB complex) iso…
Megan Murray, MD, ScD
The purpose of this study is to better understand tuberculosis (TB) and the risk of infection with TB, in Peru. TB is a disease that is caused by bacteria and transmitted through droplets in the air that come from the lungs of an infected person. The risk of infection will be com…
Long R, Lau A, Egedahl ML, Paulsen C, Heffernan C, et al.
Background Multidrug-resistant (MDR) tuberculosis has increased among migrants in Canada. The cause(s) of this increase is unknown. Methods We performed a retrospective cohort study in a Canadian province with substantially increased immigration between 1982-2001 and 2002-2019. T…
Yanagawa M, Morishita F, Oh KH, Rahevar K, Islam TA, et al.
…illion people falling ill globally in 2020. We describe the epidemiology of TB in the Pacific island countries and areas (PICs) to inform potential priority actions to implement the Western Pacific Regional Framework to End TB 2021-2030 . Methods A descriptive analysis was conduc…
Pal N, Ray R, Kundu S, Hazra A, Sau S, et al.
Multidrug -resistant tuberculosis (MDRTB) is a serious threat to mankind. India has the highest number of MDRTB cases, although majority remain undiagnosed due to inadequate diagnostic infrastructure, leading to increased community transmission and mortality. This one-year observ…
J Ntwari, R Ndiaye, L Mwiseneza, Y Habimana, E Seruyange, et al.
**INTRODUCTION:** Multidrug-resistant tuberculosis (MDR-TB) is a significant public health challenge in Rwanda. **METHODS:** This retrospective study aimed to describe the epidemiological characteristics, diagnostic approaches, and treatment outcomes of MDR-TB cases between July…
Mokaddas E, Ahmad S, Al-Mutairi N
…clusion Our study provides the first insight into molecular epidemiology of MDR-TB in Kuwait and identified six potential cases of local transmission of MDR-TB involving two to five subjects (including five Kuwaiti patients) which had escaped detection by routine surveillance stu…
Singh S, Gupta S, Jha A, Dhamnetiya D, Jha RP
Objectives Our study aims to re-evaluate the epidemiological profile and treatment outcomes of TB patients enrolled at the chest clinic of a tertiary care center after the third wave of COVID-19 in New Delhi. Patients and methods We have conducted an observational analytical stud…
Saikaew S, Thongprachum A, Pongsararuk R, Thanraka A, Kunyanone N, et al.
The epidemiology and genotypes of multidrug-resistant tuberculosis (MDR-TB), a global public health threat, remain limited. The genotypic distribution and factors associated with MDR-TB in upper northern Thailand between 2015 and 2019 were investigated. The DNA sequencing of rpoB…
Qutub M, Aldabbagh Y, Govindan P, Alamoudi E
…ve the highest incidence. This study aimed to determine the epidemiology of tuberculosis in Jeddah, the age and gender distribution and the accuracy of conventional diagnostic method, for better understanding of tuberculosis-resistant pattern in the country. Methods Three hundred…
Disratthakit A, Thawong P, Piboonsiri P, Mahasirimongkol S
Objective To support the End TB strategy with an informatics system that integrates genomic data and the geographic information system (GIS) of Mycobacterium tuberculosis (MTB) clinical isolates. We aim to develop a system prototype for implementing genomic data to support multip…
Mesquita CR, Conceição EC, Monteiro LHMT, da Silva OM, Lima LNGC, et al.
Tuberculosis (TB) is an infectious communicable disease, which despite global efforts, still needs special attention in regions with difficult access. This study aims to describe the spatial and epidemiological trends of TB incidences from 2013 to 2018 in Marajó Island, the Amazo…
Mane SS, Shrotriya P
… children. Understanding the natural history as well as the epidemiology of childhood TB is important to assess which children are the most vulnerable. It would also guide us in understanding the burden of pediatric TB on a regional, national, or global level, thus facilitating t…
Ibrahim Khalil, Nahid Afrin Nisa, Priyadarshini Deb, Mst Mahmuda Akter, Ferdous Wahid, et al.
**BACKGROUND:** Latent tuberculosis infection (LTBI) remains a critical reservoir for the global tuberculosis (TB) epidemic, particularly in South Asia, where high population density and socioeconomic disparities amplify its burden. However, LTBI epidemiological trajectories and …
Lopez B, Siqueira de Oliveira R, Pinhata JMW, Chimara E, Pacheco Ascencio E, et al.
Objectives To describe the distributions of bedaquiline and linezolid MIC values for the Mycobacterium tuberculosis WT population and to define the corresponding epidemiological cut-offs (ECOFFs) in three Latin American countries. Methods MICs of bedaquiline and linezolid were de…