Showing 101–125 of 200 documents
Sorted by hybrid relevance (keyword + semantic via RRF)
Nguyen QH, Contamin L, Nguyen TVA, Bañuls AL
At present, the successful transmission of drug-resistant Mycobacterium tuberculosis , including multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains, in human populations, threatens tuberculosis control worldwide. Differently from many other bacteria, M. tuberc…
Yani Jane Sugiri, Rezki Tantular, Silvy Amalia Falyani, Uray Riki Arif Maulana
…evolving in order to resist treatment. This has resulted in drug-resistant tuberculosis, which has a greater rate of therapy failure and mortality, as well as the necessity for other ways of disease transmission prevention. Pre-extensively drug-resistant tuberculosis (Pre-XDR TB)…
Kyla Sherwood, Shom Dasgupta-Tsinikas, David L Fuller
Abstract Background Prompt identification of drug-resistant tuberculosis (DR-TB) is crucial for the timely initiation of effective therapy, but phenotypic drug susceptibility testing (pDST) takes weeks to provide results. Advanced molecular drug susceptibility testing (mDST) allo…
Maladan Y, Krismawati H, Wahyuni T, Tanjung R, Awaludin K, et al.
…ll becomes a burden for many countries including Indonesia. Drug resistance is one of the problems in TB treatment. However, a development in the molecular field through Whole-genome sequencing (WGS) can be used as a solution in detecting mutations associated with TB- drugs. This…
Askar Zetov, Kulakhmed Erimbetov, Nargiza Parpieva, Bolat Zhetibayev, Abzal Malbaskanov
… a surgical approach in treatment of multi- and extensively drug-resistant tuberculosis.Design:The article described a retrospective analysis of surgical treatment of 246 multi- and extensively drug-resistant tuberculosis patients who were divided into 3 groups: 152 multi-drug-re…
Tang C, Wu L, Li M, Dai J, Shi Y, et al.
Drug-resistant tuberculosis (TB), especially multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB), is one of the urgent clinical problems and public health challenges. Culture-based phenotypic drug susceptibility testing (pDST) is time-co…
Zhao,Jinyun, Mao,Weifang, Jin,Faxiang, Xu,Wenfang
…l zjy19871987@163.comObjective: This study aimed to analyze drug resistance patterns, mutation profiles in Mycobacterium tuberculosis isolates and clinical characteristics of tuberculosis patients in Shaoxing, Zhejiang, China.Methods: Clinical specimens and data from tuberculosis…
Giller Db, Stepan Saenko, A. N. Gerasimov, G. V. Shcherbakova, A. A. Popova, et al.
…e effectiveness of surgical treatment in patients with multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB). Materials and methods : We examined immediate treatment outcomes of 1180 patients who underwent surgery for destructive MDRTB, pre-XDR-TB, and …
Venkata Giri Prasad Polu, Sreekanth Basireddy, Kota Neela Mani Kanta, Mithun Roy, Benson Wesly Buraga, et al.
The rise of pre-extensively drug-resistant (pre-XDR) and extensively drug-resistant (XDR) tuberculosis (TB) represents a serious threat to global health. This research investigates resistance patterns of Mycobacterium tuberculosis (MTB) clinical isolates to fluoroquinolones (FQs)…
Araújo LG, Garcia MT, Zaccariotto TR, Moretti ML, Levy CE, et al.
Multidrug-resistant tuberculosis (MDR-TB) represents a significant impact in transmission, outcome, and health costs. The World Health Organization recommends implementation of rapid diagnostic methods for multidrug-resistance detection. This study was performed to evaluate the f…
Miotto P, Zhang Y, Cirillo DM, Yam WC
…associated global threat has worsened with the emergence of drug resistance, in particular multidrug-resistant TB (MDR-TB) and extensively drug-resistant TB (XDR-TB). Although the World Health Organization (WHO) End-TB Strategy advocates for universal access to antimicrobial susc…
Habous M, Elimam M, AlDabal L, Chidambaran B, AlDeesi Z
…und The objective of this study is to determine the initial drug resistance pattern among new tuberculosis (TB) cases and assess the extent of association with human immunodeficiency virus (HIV) and diabetes mellitus (DM). Method This is a retrospective analysis of 1116 clinical …
Yang JS, Kim KJ, Choi H, Lee SH
…zolid have recently been approved for the treatment of multidrug- and extensively drug-resistant (MDR and XDR, respectively) tuberculosis (TB). To use these drugs effectively, drug susceptibility tests, including rapid molecular techniques, are required for accurate diagnosis and…
Martina L. Reichmuth, Kathrin Zürcher, Marie Ballif, Chloé Loiseau, Sònia Borrell, et al.
Abstract Background Drug-resistant Mycobacterium tuberculosis ( Mtb ) strains threaten tuberculosis (TB) control. We compared data on drug resistance obtained at clinics in seven high TB burden countries during routine care with whole-genome sequencing (WGS) carried out centrally…
Akanksha Tomar, Rajesh Tiwari, Aditi Bharti
Abstract Background: Drug-resistant tuberculosis (DR-TB) can be a menace for TB elimination, making it crucial to identify the drivers of this multifaceted challenge. Now, as drug sensitivity results are available at the commencement of the treatment, DRTB patients can be delinea…
Verma H, Nagar S, Vohra S, Pandey S, Lal D, et al.
…nfects millions of people worldwide. The emergence of multi-drug resistant (MDR), extensively drug resistant (XDR) and totally drug resistant (TDR) M. tuberculosis strains against the first- and second-line anti-TB drugs has created an urgent need for the development and implemen…
Sora Yasri, Viroj Wiwanitkit
Emergence of drug-resistant tuberculosis has become an important public health problem at present[1]. In Indochina, especially for Myanmar and Thailand, the extensively drug-resistant Mycobacterium tuberculosis is an emerging problem[2]. The extensively drug-resistant M. tubercul…
Getu Diriba, Ayinalem Alemu, Bazezew Yenew, Betselot Zerihun Ayano, Michael Hailu, et al.
…To estimate the proportion of second-line anti-tuberculosis drug resistance among multidrug-resistant tuberculosis (MDR-TB) patients in Ethiopia. **METHODOLOGY:** A laboratory-based prospective cross-sectional study was conducted at the National Tuberculosis Reference Laboratory…
N.V. Chumovatov, O.G. Komissarova, N.A. Chernykh
… was 9.9. million people. We also observed proliferation of drug-resistant TB. According to the WHO, 450,000 TB patients with multiple drug resistance (MDR) were registered worldwide in 2021, which exceeded the similar rate in 2020 by 3%. In the recent years we observed decrease …
Zhao LL, Li MC, Liu HC, Xiao TY, Li GL, et al.
…ciation between Beijing genotype and the characteristics of drug resistance. In this study, 359 M. tuberculosis isolates from south China were collected and their background information, genotype diversity and drug resistance was investigated. The results revealed that 66.0% of s…
Nimmo C, Millard J, van Dorp L, Brien K, Moodley S, et al.
Background Bedaquiline and clofazimine are important drugs in the treatment of drug-resistant tuberculosis and are commonly used across southern Africa, although drug susceptibility testing is not routinely performed. In this study, we did a genotypic and phenotypic analysis of d…
Nonghanphithak D, Chaiprasert A, Smithtikarn S, Kamolwat P, Pungrassami P, et al.
Multidrug-resistant tuberculosis (MDR TB), pre-extensively drug-resistant tuberculosis (pre-XDR TB), and extensively drug-resistant tuberculosis (XDR TB) complicate disease control. We analyzed whole-genome sequence data for 579 phenotypically drug-resistant M. tuberculosis isola…
Sheng-Han Wu, Hsin-Yi Liu, Kuang-Hung Liu, Hseuh-Chien Hsiao, Ruwen Jou
Cycloserine (CS) is a widely used drug for drug-resistant tuberculosis (DR-TB) treatment. The World Health Organization (WHO) recently suggested a critical concentration (CC) for CS using the MGIT 960 system (MGIT). To strengthen our DR-TB management program, we performed CS resi…
Ehssan Moglad, Hisham N. Altayb
…tant pattern for different clinical isolates to control the resistance phenomena. This study was designed to provide the resistance pattern of isolated Staphylococcus spp. from various clinical samples in Khartoum State and to elucidate the frequencies of Multidrug-resistant (MDR…
Xi-Ling Huang, Aliaksandr Skrahin, Pu-Xuan Lu, Sofia Alexandru, Valeriu Crudu, et al.
Abstract Multidrug-resistant tuberculosis (mdrtb) refers to TB infection resistant to at least two most powerful anti-TB drugs, isoniazid and rifampincin. It has been estimated that globally 3.5% (which can be much higher in some regions) of newly diagnosed TB patients, and 20.5%…