Showing 101–125 of 200 documents
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Leonce Leandry, Egbert Mujuni, Eunice Mureithi, Morten Brun, Mary Mayige
…threat to public health, particularly with the emergence of drug-resistant strains. Research shows that first-line anti-tuberculosis drugs are increasingly failing, and second-line drugs are also showing resistance. This study investigates the evolutionary dynamics of second-line…
Liu J, Shi W, Zhang S, Hao X, Maslov DA, et al.
Although drug resistance in Mycobacterium tuberculosis is mainly caused by mutations in drug activating enzymes or drug targets, there is increasing interest in the possible role of efflux in causing drug resistance. Previously, efflux genes have been shown to be upregulated upon…
Nachappa SA, Neelambike SM, Sarikhani A, Ramachandra NB
A molecular method for diagnosis of drug-resistant Tuberculosis is Multiplex allele-specific PCR (MAS-PCR), which is more time-efficient, and its accuracy is studied using DNA sequencing. Also, understanding the role of mutations, when translated to protein, in causing resistance…
Ayu Rahayu, Anwar Rovik, Oktaviani Naulita Turnip
…st case recorded was 821,200 cases in 2023 over one decade. Drug resistance significantly impacts tuberculosis treatment and has been observed since the first drug discovery, streptomycin. In Indonesia, drug-resistant tuberculosis (DR-TB) is a significant public health issue, wit…
Bawlah Tahir, Abdi Osman, Kalid Fuad, Hadis Mahamed, Niman Tayib
…h Tuberculosis worldwide. Emergence of Rifampicin and multi-Drug resistance has posed greater public health threat on control and prevention of TB. Ethiopia is among the top 30 high Tuberculosis burden countries. **OBJECTIVE:** To determine the Magnitude of Tuberculosis, drug re…
Vishant Boradia, Junxi Chen, Andrew Frando, Lindsay V Clark, Christoph Grundner
…(OM) creates a formidable permeability barrier, and whether drugs traverse it by mechanisms other than passive diffusion remains unclear. The proline-glutamic acid (PE) and proline-proline-glutamic acid (PPE) proteins of pathogenic mycobacteria include several OM transporters. Be…
Basrai A, Blundell TL, Pandurangan AP
…ed way, further our understanding of the molecular basis of drug resistance, and design new antibiotics. Here, we focus on a key drug-resistant pathogen, Mycobacterium tuberculosis, and computationally analyze trends in drug-resistant mutations in genes of the proteins embA, embB…
Pushpendra Singh, Mukul Sharma
…h dapsone, rifampicin, and clofazimine, also known as multi-drug therapy (MDT), as per the recommendations of WHO since 1981. Still, the number of new leprosy cases recorded globally has remained constant in last one-decade, and resistance to multiple drugs has been documented in…
Priyo Purnomo As’hab, Budi Anna Keliat
The rate of drug-resistant treatment in the world is still low. Success rates are affected by medication adherence, while loss to follow-up (LTFU) is still found in patients with drug-resistant tuberculosis. It is important to know the factors that influence to make an effort to …
О.А. Рыжкова, Е Н Стрельцова, N. B. Kasimova
Resistance of Mycobacterium tuberculosis (MTB) to TB drugs is a major factor of TB progression and patient death. TB caused by drug resistant strains commonly has protracted progressive course. The immune response to TB plays a significant role in the disease outcome. Interferons…
Erfaneh Jafari, Reza Azizian, Mohsen Tabasi, Morteza Banakar, Kamran Bagheri Lankarani
… by, remains a major global health burden. The emergence of drug-resistant strains presents a critical challenge in TB management. The recent research has explored the interaction between TB and the human gut bacteriophage community (phageome). The gut phageome plays a crucial ro…
Hajiaheman Y, Yang Y, Shayilanbieke N, Jin G
This study aims to elucidate the strains and drug resistance of mycobacterium isolated from osteoarticular tuberculosis (OATB) patients and provide a reference for the diagnosis and treatment of OATB.Sixty-nine clinically diagnosed and surgically treated OATB patients were collec…
Gupta H, Arora R, Chadha M, Dhammi IK, Jain AK
Background Management outcomes of drug-resistant (DR) osteoarticular tuberculosis (OATB) is dismal as in pre-ATT era (1905). The studies documenting treatment outcome of DR-OATB are scarce; hence, present retrospective analysis was conducted to evaluate outcome of consecutive cas…
Mirae Park, Priya Solanki, Timothy Daniel McHugh, Onn Min Kon, Giovanni Satta
**OBJECTIVES:** Rapid identification of drug-resistant tuberculosis remains critical for the initiation of appropriate treatment regimens, improved success rates and reduction in the development of drug resistance. In this study, we compared the diagnostic performance of two nove…
Shufang Wen, Haoran Li, Yiheng Shi, Rongrong Wei, Fei Ge, et al.
**BACKGROUND:** Despite global efforts to combat drug-resistant tuberculosis (DR-TB), key gaps remain in understanding how resistance amplifies during treatment and the role of collateral drug effects in this process. Resistance amplification complicates management and undermines…
Shuying Zhang, Juan Cheng, Yuanyuan Tang
Drug-resistant(Mtb) has become a global public health crisis, and its diverse drug resistance jointly reduces the effectiveness of antibacterial drugs. Mtb resistance is not merely genetic but involves a synergistic interplay of cell wall remodeling, metabolic reprogramming, and …
Sushma Yadav, Surya Kant, Amita Jain, Jyoti Bajpai
Title- Molecular characterization of drug‑ resistant strains of Mycobacterium tuberculosis <b>Background:</b> Tuberculosis is a serious infectious disease affecting millions of people. In fact, the increased cases of multi (MDR) and extreme drug resistance (XDR) worldwide r…
Myrzaliev B, Ahmatov M, Duishekeeva A, Kulzhabaeva A, Kadyrov A, et al.
Settings In Kyrgyzstan, drug-resistant tuberculosis poses a significant challenge. Recognizing the potential of the BPaL regimen, the World Health Organization recommended its use for selected drug-resistant TB cases under operational research conditions in 2020. Objective This r…
Teodora Butnaru, Florin Mihălţan, Constantin Ancuţa
Abstract Drug-resistant tuberculosis (DR TB) is a major threat worldwide, despite the fact that the EndTB strategy involves early diagnosis and prompt treatment of all people of all ages with any form of sensitive or drug-resistant tubrculosis. Both forms of tuberculosis imply hi…
Mehdi Roshdi Maleki
…h due to infectious disease. Additionally, the emergence of drug-resistant strains has created a significant challenge for the treatment of this disease. Approximately 25% of TB-related deaths are attributed to antimicrobial drug resistance. Various mechanisms contribute to the d…
Helen Ding, Norman Mang, Jordan Loomis, Jessica K. Ortwine, Wenjing Wei, et al.
…al distribution of causative pathogens and their associated resistance patterns in CAP is unknown. A retrospective observational study was performed of patients admitted to an 870-bed safety net hospital between March 2016 and March 2021 who received a diagnosis of CAP or healthc…
А. Э. Эргешов, Л. Н. Черноусова, Sofya Andreevskaya
Widespread drug-resistant tuberculosis is a global challenge that has a potential to have a negative impact on the global TB situation. Rapid TB diagnosis and early initiation of effective treatment based on the individualized chemotherapy regimens underpin efforts in prevention …
Camus Nimmo
Drug-resistant tuberculosis (DR-TB) remains a major global health challenge with increasing numbers of cases reported each year. Whole genome sequencing (WGS) is used increasingly in both research and clinical services to rapidly identify drug resistance. Mycobacterium tuberculos…
Xin Wang, Dongpeng Geng, Xiaoling Wu, Zhen Guo, Conglong Ma, et al.
**INTRODUCTION:** Drug-resistant tuberculosis presents a major global health challenge due to limited therapeutic options and significant toxicity of traditional regimens. Linezolid, a core Group A drug per WHO guidelines, demonstrates high efficacy but its optimal dosing is deba…
Zhang G, Aldrich CC
…othiazin-4-one, C 20 H 23 F 3 N 4 O 3 S} is a promising new drug for treating drug-sensitive and drug-resistant TB that has successfully completed phase I clinical trials. We report the complete spectroscopic and structural characterization by 1 H NMR, 13 C NMR, HRMS, IR, and X-r…