Showing 101–125 of 200 documents
Sorted by hybrid relevance (keyword + semantic via RRF)
Sema Aytac
…İncomplete treatment may result in long-lasting infection, drug resistance, relapse, and death. In the litareture, it has been stated in the study conducted with the individuals with some chronic diseases that tele-follow-up is effective in providing the self-care agency of pati…
Li TL, Chan TH, Wang CH, Jou R, Yu MC, et al.
… cough and was found to harbor active TB disease with added resistance to isoniazid. An individualized anti-TB regimen consisting of moxifloxacin, kanamycin, prothionamide, ethambutol, and pyrazinamide was prescribed for 20 months, leading to sputum culture conversion and improve…
Dr.Anmar Talib, Rafeef Y. Rashid Rashid
…le brook media, remain the cornerstone for confirmation and drug susceptibility testing, even though they may be time-consuming. The advanced and automated liquid culture systems like BACTEC MGIT 960 have markedly decreased detection time while keeping excessive sensitivity and s…
F Wu, R Huang, X Zhu, Y Lin, F Fang, et al.
… significant global health challenge, exacerbated by rising drug resistance and the shortcomings of current diagnostic methods. Macrophages, key players in the innate immune response to TB, are regulated by the protein tyrosine phosphatase receptor type O (PTPRO), which influence…
Kelly AM
Drug-resistant tuberculosis (TB) is one of the greatest challenges facing the elimination of TB. In the United States, persons born outside the United States account for 70% of new TB cases. Nucleic acid amplification testing has greatly reduced the amount of time needed for diag…
Kaur S, Angrish N, Gupta K, Tyagi AK, Khare G
… TB chemotherapeutic regimen, resulting in the emergence of drug resistance strains, poses a serious problem in the cure of the disease. Further, one-quarter of the world's population is infected with dormant M.tb, which creates a lifetime risk of reactivation. M.tb has a remarka…
Anchalee Avihingsanon, MD, PhD
…ns, adherence to the treatments, and patterns of antibiotic resistance among Mycobacterium tuberculosis (MTB) isolates in participants who fail on these prophylactic regimens. Under this study, there is one substudy entitled, "Pharmacokinetic study of rifapentine, dolutegravir, …
Unki P, Kondekar S, Morkhade K, Rathi SP, Rathi PM
…been modified in immunocompromised children. The concept of drug resistance has to be kept in mind before using anti tubercular drugs without any bacteriological evidence for tuberculosis. National Tuberculosis Elimination Programme (NTEP) focuses on contact tracing and treatment…
Colangeli R, Gupta A, Vinhas SA, Chippada Venkata UD, Kim S, et al.
…nt state during latency, decreasing the risk for mutational drug resistance and increasing generation time, but potentially increasing bacterial tolerance to drugs that target actively growing bacteria.
Greco GLC, Segretti N, Abad-Zapatero C, Movahedzadeh F, Hirata MH, et al.
…infection (LTBI). Failure to fully treat LTBI can result in drug-resistant forms of TB. Therefore, it is essential to develop novel drugs with unique mechanisms of action to combat TB effectively. One crucial metabolic pathway in Mycobacterium tuberculosis ( Mtb ), which contribu…
Inês Alexandra Cesário e Araújo
…tics were used to compare the influence of the model on the resistance/susceptibility to common anti-TB drugs. The results show that cells readily form 3D cellular aggregates around infected cells. The model could be maintained for several weeks before bacteria-induced cell necro…
Lana Fadl, Arowa Abdelgadir, Hendy Mirza, Aqsa Mahreen, Siddalingana Gouda
…smission risks, especially to immunocompromised patients on drugs like adalimumab and infliximab. Immunocompromised status may cause false-negative TB screening results, highlighting the need to consider chemoprophylaxis for high-risk patients. In this case, anti-TB medications w…
Dewi Oktavia Djasmi, Roza Kurniati, Fauzar
…ce of exudate. Patients were treated with anti-tuberculosis drugs, namely Isoniazid, rifampicin, pyrazinamide, and ethambutol, with pyridoxine. Anti-tuberculosis drug therapy in the intensive phase is given for 2 months and is continued for 6-9 months for the continuation phase, …
Richard E. Chaisson, MD, Susan Swindells, MBBS
HIV-infected people have an increased risk of developing active tuberculosis (TB). At the time the study was designed, the standard course of treatment for TB was 6 to 9 months of isoniazid (INH).This study compared the safety and effectiveness of a 4-week regimen of rifapentine …
Soedarsono Soedarsono
Tuberculosis (TB) still becomes a public health crisis. Drug-resistant TB (DR-TB) becomes a concern as the increasing DR-TB cases in countries with high TB burden. The 2017 World Health Organization (WHO) guideline recommended a combination of TB treatment consisting of 2 months …
Olga Gordeeva, Natalya Karpina, Sofya Andreevskaya, Е. Е. Ларионова
…d hematotoxic reactions - 2.6%. Most often canceled anti-TB drugs: H - 12.8%, Z - 12.8%, R - 10.3%, Et - 10.3%, PAS - 5.1%, one patient per each drug reported improvement after withdrawal Lfx, Am, Cs, Pt. <b>Conclusion:</b> Patients with drug-resistant TB predominate - 68.2%. Dur…
Tayal A, Kabra SK
…mo of weekly Isoniazid and Rifapentine). TPT to contacts of drug resistant TB (DR-TB) patients needs to be tailored depending on the resistance pattern in the index case, and relies on a bacteriological confirmation of the same. Individuals receiving TPT should be closely monitor…
All India Institute of Medical Sciences
…rtality and morbidity. Inspite of effective Anti-tubercular drugs, still around 30% of patients develop complications due to arachnoiditis such as spinal tubercular radiculomyelitis, optico-chiasmatic arachnoiditis, development of new tuberculomas after starting therapy etc. whic…
Divya Umapathy, S. Ranjani, S. Hemalatha, D Mhango, D Mzinza, et al.
…olecular docking-based virtual screening of 10 FDA-approved drugs which already used to treat bacterial infections against target methoxy mycolic acid synthase 4 (MMA4) and cyclopropane mycolic acid synthase (CmaA2). Drug-resistant TB is the most challenging factor for the design…
Aravindhan V, Yuvaraj S
… bacillary load, delayed sputum conversion, higher rates of drug resistance, higher lung cavitary involvement and extra-pulmonary TB infection, which is called as "Diabetes-Tuberculosis Nexus". However, recently we have shown a reciprocal relationship between latent tuberculosis …
Chem Int
…cobacterial cell wall is very complicated, which makes many drugs ineffective. Tuberculosis is still one of the most imperative infectious disease worldwide becouse its important reason is drug resistant, persistent or latent tuberculosis and synergism with HIV. Furthermore no an…
Rabaan AA, Halwani MA, Garout M, Turkistani SA, Alsubki RA, et al.
…society since time is not clearly defined. The existence of drug-resistant strains and the potential threat posed by latent tuberculosis act as strong impetuses for developing novel anti-tuberculosis drugs. In this study, various flavonoids were tested against the Mycobacterium t…
Aher RB, Sarkar D
…osis (MTB) is not killed by the conventional antitubercular drugs. The treatment of latent TB is essential to reduce the period of treatment as well as incidences of drug resistance. In this background, we have made an attempt to develop the quantitative structure-activity relati…
Bahuaud O, Genestet C, Hoffmann J, Dumitrescu O, Ader F
…(TB) treatment requires the combination of multiple anti-TB drugs during 6 months or more depending on strain drug susceptibility profile. Optimizing the monitoring of anti-TB therapy efficacy is required to provide adequate care and prevent drug resistance emergence. Moreover, a…
Bwarenaba B Kautu
…IV/AIDS. Furthermore, the continued emergence and spread of drug-resistant forms of TB are increasingly a problem, causing increased mortality and global economic loss. One of the fundamental gaps that exists in the control of TB is the lack of rapid, ultra-sensitive, inexpensive…