Showing 101–125 of 200 documents
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Charles Kenechukwu Okoro, A. Abdullahi, Ayodeji Oluwatobi Ojetunde, Abdulmudallib Ibrahim
…acteria called Mycobacterium tuberculosis. The treatment of drug-resistant tuberculosis is complex, costly, and usually has poor outcomes. Treatment default is well known as a very significant factor associated with drug-resistant tuberculosis.
 The aim of this study was to …
Е. В. Корж, Н. А. Подчос
…se of (Group I); 17 patients who received anti-tuberculosis drugs for tuberculosis in other sites and in whom, after ART initiation, the course of tuberculosis worsened and TM developed (Group II); 16 patients who started ART at the pre-hospital stage without a previously diagnos…
O.D. Nikolayeva
…leads to an increase in the incidence of extrapulmonary and drug-resistant forms of tuberculosis (TB). One of the most dangerous forms of TB in HIV-infected persons is the generalized form with damage to the central nervous system (CNS). The paper deals with the peculiarities of …
Mohammad Julhas Sujan, Afzalur Rahman, Abu Taleb, Ahmadul Hasan Khan, Shanjida Rahman Sultana, et al.
… TB retention. High retreatment failure rates demand better drug-resistant TB management. Key priorities: 1) age-specific protocols, 2) gender-sensitive interventions, 3) improved rural children’s care, and 4) enhanced drug-resistant TB services. Addressing these gaps is v…
Abdalla Fathi Salih, Shameen Malik
…y 90 mL of pus, which tested positive forwithout rifampicin resistance. Initial empiric therapy with flucloxacillin was discontinued, and antitubercular therapy was commenced. Subsequent drug susceptibility testing revealed isoniazid resistance, prompting regimen modification to …
T. J. P. Pinto, Yuvaraj B. Chavan, Vijaykumar Singh
…er in an urban slum in Mumbai. Results: The total number of drug sensitive TB cases reported in 2022 was 519. Males constituted 42% and females 58%. The most common age group affected was 20-29 years. Pulmonary cases comprised 66.9% of the cases. The total number of Drug resistan…
Advani J, Sharma K, Verma R, Chatterjee O, Solanki HS, et al.
…dentify single nucleotide variations (SNVs) associated with drug resistance. A total of 214 SNVs in the coding and promoter regions were identified in the whole genome sequencing analysis. Among the identified SNVs, 18 SNVs were identified in genes known to be associated with fir…
Abdugapparov F, Grigoryan R, Parpieva N, Massavirov S, Riskiyev A, et al.
…value 0.011). Multivariable regression analysis showed that drug-resistant TB was independently associated with unsuccessful TB treatment outcome. (RR 3.83; 95%CI: 1.05-14.02, p value 0.04). Multidisciplinary approaches are required to maximize the diagnostic accuracy of TPE and …
Tulika Goswami Mahanta, Malinee Goswami, Nabanita Nirmolia, Baidurjya Mahanta, Ravi Baruah, et al.
…sited DTC. Newly diagnosed cases were 85.1%, while 2.1% had drug-resistant TB. Pulmonary TB comprised 51% and extrapulmonary TB was 42.3% mostly affecting lymph nodes (10.7%). Nearly 51.87% of patients completed their treatment and girls exhibited a higher cure and treatment comp…
Gevorgyan L, Grigoryan R, Dumchev K, Akopyan K, Khachatryan A, et al.
… patients receiving TB treatment with first- or second-line drugs from 2015 to 2019. Data were obtained from the TB and HIV electronic databases. We analysed occurrence of the combined unfavourable outcome (failure, lost to follow-up, death and not evaluated) and death separately…
Aljohaney AA
…luded demographics, clinical, radiological, laboratory, and drug resistance data. Results Of the 291 patients, 168 had pulmonary TB, 39 had extrapulmonary TB, and 84 had both pulmonary and extrapulmonary TB. After a mean hospital stay of 1.74 months, 85.9% were successfully treat…
E. O. Bryukhacheva, ELENA N. LUKASHOVA, ARTYOM A. KHOLODOV, TATYANA V. PYANZOVA
…portion of children and adolescents receiving treatment for drug-resistant forms of tuberculosis (p =0,001, OR=16,084). Conclusion. The incidence of tuberculosis among children and adolescents in Kuzbass has decreased significantly in recent years. At the same time, the age of si…
Mehta N, Tyagi M, Ramam M, Khaitan BK
…ile pulmonary NTM infections are on the rise, partly due to drug resistance and possible patient-to-patient transmission, there is no current evidence indicating an increase in cutaneous NTM infections. The clinical manifestations of NTM infections, except for well-known entities…
Niu Q, Wu R, Pan K, Ge X, Chen W, et al.
…considered and the differences in pathological features and drug resistance were analyzed and compared with those for pulmonary tuberculosis (PTB). Enhanced CT scans showed ring-shaped delayed enhancement during the arterial, venous, and delayed phases. Most HTB cases were single…
Mailla Mylena Mendes Bergmann, Leonardo Gonçalves Artoni, Josué Rulian Mendes Paneque, Roberto Carlos Cruz Carbonell, Joquebede de Lima Bezerra Carbonell, et al.
…also evaluated. A comparative analysis of the occurrence of drug-resistant TB (TB-DR) was performed between the group of healthcare professionals and the total TB cases in Brazil. Between 2014 and 2024, a total of 12.374 TB cases were reported among healthcare professionals in Br…
Qiang Niu, Runrui Wu, Ke Pan, Xinlan Ge, Wen Chen, et al.
…considered and the differences in pathological features and drug resistance were analyzed and compared with those for pulmonary tuberculosis (PTB). Enhanced CT scans showed ring-shaped delayed enhancement during the arterial, venous, and delayed phases. Most HTB cases were single…
Dian S, Ganiem AR, Te Brake LH, van Laarhoven A
… for neurotuberculosis remains high. While antituberculosis drugs were discovered in the 1940s, TB treatment regimens were designed for and studied in pulmonary TB and remained largely unchanged for decades. However, new antibiotic regimens and host-directed therapies are now bei…
Praveen Kumar Tagore, Mahendra Kumar Bharti, Manish Kumar Sachan
…=0.011). The culture positivity (78.3 vs 58.3, p=0.015) and drug resistance (multidrug- resistance: 15.0 vs 3.3, p=0.026) were more positive in microbiologically positive patients of DM. The results of treatment showed slower conversion of sputum in DM patients (8.3±2.1 vs 6…
Muluye AB, Kebamo S, Teklie T, Alemkere G
…hallenged by the development and spread of antituberculosis drug resistance. The resistance is often correlated to the absence of properly implemented control measures that lead to poor treatment outcomes. Therefore, the aim of the current study was to assess poor treatment outco…
Anchu R Nath, Nayanabai Shabadi, И. М. Сон, P V Manirsha
…ions, limited sensitivity of conventional diagnostic tools, drug resistance, and poor drug penetration in specific tissues. Variability in treatment practices and the need for standardized protocols were also highlighted. Conclusion:The study underscores the complex nature of EPT…
Napoleón González Saldaña, Mercedes Macías Parra, Eduardo Arias de la Garza, Sairy Pérez Murillo, Manuel Eugenio Narro Flores, et al.
…orter time of presentation (< 4 months) (P = 0.005). Polydrug resistance (resistance to ≥2 drugs, excluding those classified as MDR) was observed in five strains (22.7%). We detected 3 RIF-resistant strains (19%), 2 INH-resistant strains (9.1%), and 1 EMB-resistant strain (4.5…
Ahmad R Ganiem, MD, PhD
… the model for pulmonary TB by using the same first-line TB drugs (a combination of rifampicin, isoniazid, pyrazinamide and ethambutol) and the same dosing guidelines, although it is known that penetration of two of these drugs (rifampicin and ethambutol) into cerebrospinal fluid…
Motohiro Yukitake
…ts with TBM suffering from HIV co-infection and alternative drug selection for drug-resistant TBM cases are also introduced. Although TMB is a rare central nervous system infection, it remains a serious disease with high rates of mortality and neurological sequelae. Knowing thera…
K. Lakshmi, Radhika Santhanam, S Chitralekha
… results. Empirical treatment with at least four first-line drugs, preferably isoniazid, rifampin, pyrazinamide, and streptomycin or ethambutol is usually started in clinical suspected cases with supportive initial CSF findings. Corticosteroid can be added as adjunctive treatment…
Aliya Moreira, Dana Hassneiah, Ruvandhi R. Nathavitharana
…PTB), and one had both PTB/EPTB. Six (43%) had some form of drug-resistance, predominantly isoniazid-resistant TB (29%). The majority (93%) were non-US born. The duration of inpatient isolation was 15.2 ± 8.3 days (mean ± standard deviation) (16.2 days for PTB, 13.4 days for EPTB…