Showing 101–125 of 200 documents
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Paul K. Drain, MD, MPH, FACP, Douglas Wilson, MD
…nce LAM test, or to share with partners developing novel TB diagnostics, including new LAM antibodies. The project will be coordinated at the University of Washington, and conducted in partnership with clinical research partners in South Africa, including Umkhuseli Innovation and…
Sofia Kostoudi, Robert Hammond
…aims to examine and analyze the present and proposed future diagnostics in the identification of latent tuberculosis. Design Systematic Review Methods PubMed and Scopus were scanned as primary databases during May 2022. Exclusion criteria for the papers scanned included patients …
Peewara Thampanyawat, Patsharaporn T. Sarasombath, Anupop Jitmuang, Kamonthip Kunwipakorn
Abstract Background The prevalence of Pneumocystis pneumonia (PCP), primarily affecting immunocompromised individuals, notably those without HIV infection, has been increasing. Diagnosing PCP is challenging due to the lack of a standard definition. Its diagnosis mainly relies on …
Tushar Garg, Vivek Gupta, Dyuti Sen, Madhur Verma, Miranda Brouwer, et al.
…ompanied by the CHW to a designated government facility for diagnostics. Those with a confirmed TB diagnosis were put on treatment by the CHW and followed-up till treatment completion. All services were provided free of cost and patients were supported throughout the care pathway…
Holtgrewe LML, Jain S, Dekova R, Broger T, Isaacs C, et al.
Rapid and accurate point-of-care (POC) tuberculosis (TB) diagnostics are crucial to bridge the TB diagnostic gap. Leveraging recent advancements in COVID-19 diagnostics, we explored adapting commercially available POC SARS-CoV-2 tests for TB diagnosis in line with the World Healt…
Wenhua Gu, Bo Yang, Tongyangzi Zhang, Yiqing Zhu, Wanzhen Li, et al.
Background Finding a simple, effective and rapid diagnostic method to improve the diagnosis of gastroesophageal reflux-induced chronic cough (GERC) is indicated. Our objective was to determine the diagnostic value of the pepsin concentration in saliva and induced sputum for GERC.…
Takashi Okuma, Eri Hagiwara, Ryo Okuda, T. Oda, Ryota Otoshi, et al.
Abstract Background: In asymptomatic patients with pulmonary Mycobacterium avium complex (MAC) disease, sputum culture testing can be challenging, often leading to difficulty in diagnosis. To investigate the usefulness of gastric juice culture, this study examined the clinical ch…
Alice Halliday, Pooja Jain, Long Hoàng, Robert Parker, Mica Tolosa-Wright, et al.
Background Tuberculosis (TB) is a devastating disease for which new diagnostic tests are desperately needed. Objective To validate promising new technologies [namely whole-blood transcriptomics, proteomics, flow cytometry and quantitative reverse transcription-polymerase chain re…
Rahma Isti Kusyadi, Lita Diah Rahmawati, Prastuti Asta Wulaningrum
**INTRODUCTION:** Poncet's disease (PD) is a rare form of TB-associated reactive arthritis, presents a major diagnostic challenge due to its close resemblance to rheumatoid arthritis and tuberculous septic arthritis. A clear diagnostic workflow is essential to support clinical de…
Halliday A, Jain P, Hoang L, Parker R, Tolosa-Wright M, et al.
Background Tuberculosis (TB) is a devastating disease for which new diagnostic tests are desperately needed. Objective To validate promising new technologies [namely whole-blood transcriptomics, proteomics, flow cytometry and quantitative reverse transcription-polymerase chain re…
Mercy Corps Pakistan
…ity, cost-effectiveness, and turnaround time of the new NAT diagnostics compared to the Xpert Ultra platform. The strategy will involve both quantitative and qualitative research methods. Quantitative data will be collected and analyzed regarding the cost per test and the time ta…
R. Nath, Pranav Ish, Kumari Harshita, Ashish Sethi
…acillary loads, which lower the sensitivity of conventional diagnostics.[7] AI models trained on diverse datasets may help detect subtle radiological or clinical patterns, thus improving case detection in this vulnerable subgroup. Molecular diagnostics are also being transformed …
John Abel, Surya Dharun
…undetected transmission within herds. Advances in molecular diagnostics and non-invasive sampling strategies in human tuberculosis have demonstrated that Mycobacterium tuberculosis DNA can be reliably detected from oral surfaces, including tongue swabs, using PCR-based methods. T…
John Abel, Surya Dharun
…undetected transmission within herds. Advances in molecular diagnostics and non-invasive sampling strategies in human tuberculosis have demonstrated that Mycobacterium tuberculosis DNA can be reliably detected from oral surfaces, including tongue swabs, using PCR-based methods. T…
Khalid Alyahyawi
…opic features, histopathological characteristics, molecular diagnostics, pharmacological therapy, and minimally invasive therapeutic interventions. Accurate diagnosis requires an integrated approach combining clinical assessment with imaging, endoscopic evaluation, and histopatho…
Yating Zhao, Longting Du, Junli Song, Wei Sun, Yili Chen, et al.
…Our findings provide actionable solutions for optimizing TB diagnostics in diverse healthcare ecosystems, aligning with the WHO's End TB Strategy to ensure equitable access to rapid diagnostics.
Jorge E Leiva-Ordoñez, Beatriz Quintero
Tuberculous meningitis is the most severe form of tuberculosis and remains associated with high mortality and substantial neurological disability, particularly among children and people living with HIV. Early diagnosis is challenging because of nonspecific clinical manifestations…
Padingani M, Kumar A, Tripathy JP, Masuka N, Khumalo S
Introduction While there are many studies assessing the pre-treatment loss to follow-up (LFU) among tuberculosis patients in public sector, there is no evidence from private-for-profit health sector and pre-diagnostic LFU from Zimbabwe. We aimed to assess the gaps in the cascade …
J Stübler, L Denkmayr, M J Studnicka, P Kaiser-Krug
Abstract Rationale Endobronchial ultrasound-guided (EBUS) TBNA is the current standard for minimally invasive sampling of mediastinal/hilar lymph nodes. However, cytological specimen may not be sufficient for diagnosis requiring preserved tissue architecture. EBUS-guided TBINCB h…
Nichols BE, de Nooy A, Cassim N, Hans L, da Silva MP, et al.
Introduction To ensure there is adequate investment into diagnostics, an understanding of the magnitude of impact and return on investment is necessary. We, therefore, sought to understand the health and economic impacts of the molecular diagnostic programme in South Africa, to d…
B Bermawi, Dewi Kurniasari, Ayunda Imaniar, Nurul Hidayatih, Diana Arum Lisnawati, et al.
INTRODUCTION: Tuberculosis (TB) is a serious global health problem in Indonesia, which is the country with the secondhighest TB burden after India. Accuracy in TB diagnosis is the key to effective treatment and decreased transmission rate. One of the latest diagnostic methods is …
Yan Z, Wen JX, Wang H, Jiang TW, Huang JH, et al.
Background This study aimed to evaluate the diagnostic accuracy of pleural fluid (PF) lactate dehydrogenase (LDH) to adenosine deaminase (ADA) (LDH/ADA) ratio for tuberculous pleural effusion (TPE). Especially to explore whether the LDH/ADA ratio provides added diagnostic value t…
Meryem Sena Kaya, Sibel Yıldız Kaya, Rıdvan Karaali, Günay Can, İlker İnanç Balkan, et al.
**BACKGROUND:** Fever of unknown origin (FUO) remains a significant diagnostic challenge. Changes in patient populations and diagnostic technologies may shift the spectrum of underlying etiologies. This study aimed to examine recent FUO cases at a single tertiary center to identi…
Birendra Gupta, Natalia Blanco, Chandramani Wagle, Nikita Acharya, Jyoti Takanche, et al.
**BACKGROUND:** Pyrexia of Unknown Origin (PUO) represents a persistent diagnostic challenge in clinical practice. In South Asian regions, this challenge is compounded by a high burden of endemic infections, resource constraints, and varied clinical practices. This systematic rev…
Xuegang Zhou, Nan Tang, Xiuqing Liao, Xiaoli Bao
**BACKGROUND:** Bronchoalveolar lavage fluid (BALF) Xpert Mycobacterium tuberculosis and rifampicin resistance (Xpert MTB/RIF) is increasingly used as an important diagnostic method for sputum smear-negative pulmonary tuberculosis (PTB) in many countries. However, no studies have…