Showing 76–100 of 200 documents
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Shanghai Pulmonary Hospital, Shanghai, China
…loxacin, and pyrazinamide in patients with drug-susceptible tuberculosis. This is a prospective, randomized, controlled, multicenter study planned to enroll 45 rifampicin-susceptible tuberculosis patients, who will be randomized in a 1:1:1 ratio to the BZMD group (bedaquiline + p…
Wei X, Hicks JP, Zhang Z, Haldane V, Pasang P, et al.
…ed as a complement to directly observed treatment (DOT) for tuberculosis, as DOT is inconvenient and costly. However, existing evidence about the effectiveness of these monitors is inconclusive. Therefore, we evaluated the effectiveness of a comprehensive package based on electro…
Amira Mahmood, Mohammad Bilal Ashfaq, Catherine Drain, Eoin Melby, Michael Hunter, et al.
Tuberculosis remains the biggest global killer from infectious causes, with an estimated 1.25 million deaths per year. The quadruple drug regimen of rifampicin, isoniazid, pyrazinamide, and ethambutol has been standard therapy for 40 years, with good outcomes in patients with dru…
Chatterjee S, Das P, Shikhule A, Munje R, Vassall A
Historically, economic studies on tuberculosis estimated out-of-pocket expenses related to tuberculosis treatment and catastrophic cost, however, no study has yet been conducted to understand the post-treatment economic conditions of the tuberculosis patients in India. In this pa…
Rada Savic, PhD
The Tuberculosis Trials Consortium (TBTC) phase 3 treatment trial, Study 31, will investigate the efficacy and safety of daily rifapentine (1200 mg daily) with or without moxifloxacin as part of multidrug treatment regimens for drug-sensitive pulmonary TB. The proposed study (Stu…
Prince Malonda ma Ndungi, Blaise Idiamwana Kutokama, Bijou Masokolo Malamba, Dosithée Ngo-Bebe
Background Tuberculosis, the second deadliest infectious disease in the world after COVID-19, is caused by Mycobacterium tuberculosis. This bacterium most commonly affects the lungs. Economic and financial barriers can hinder access to healthcare services for the diagnosis and ma…
Jiwon Lyu, Tae Sun Shim
…tant thing for the management of drug susceptible pulmonary tuberculosis is to diagnose active pulmonary tuberculosis as soon as possible and prevent the occurrence of new patients through appropriate treatment. Therefore, it should be a priority to quickly detect tuberculosis my…
Bonnet M, Vasiliu A, Tchounga BK, Cuer B, Fielding K, et al.
Background Globally, the uptake of tuberculosis-preventive treatment (TPT) among children with household tuberculosis contact remains low, partly due to the necessity of bringing children to health facilities for investigations. This study aimed to evaluate the effect on TPT init…
Safi H, Gopal P, Lingaraju S, Ma S, Levine C, et al.
The length and complexity of tuberculosis (TB) therapy, as well as the propensity of Mycobacterium tuberculosis to develop drug resistance, are major barriers to global TB control efforts. M. tuberculosis is known to have the ability to enter into a drug-tolerant state, which may…
Suresh S, Begum RF, Singh SA, Vellapandian C
…ng and clever strategy that is being developed to eradicate tuberculosis amid challenges, of which one of the major challenges is the resistance developed towards antibiotics used in standard directly observed treatment, short-course regimen. Surpassing the challenges in developi…
Lee GO, Comina G, Hernandez-Cordova G, Naik N, Gayoso O, et al.
Cough is a characteristic symptom of tuberculosis, is the main cause of transmission, and is used to assess treatment response. We aimed to identify the best measure of cough severity and characterize changes during initial tuberculosis therapy. We conducted a prospective cohort …
Li X, Qi X, Wang B, Fu L, Chen X, et al.
…ed the need for alternative therapies against Mycobacterium tuberculosis, the causative agent of TB. Methods MICs and intracellular macrophage cfu counts were tested to evaluate the antibacterial activity of nintedanib and pirfenidone against drug-susceptible and -resistant M. tu…
Musisi E, Dide-Agossou C, Al Mubarak R, Rossmassler K, Ssesolo AW, et al.
… need for improved pharmacodynamic markers for use in human tuberculosis (TB) drug trials. Pharmacodynamic monitoring in TB has conventionally used culture or molecular methods to enumerate the burden of Mycobacterium tuberculosis organisms in sputum. A recently proposed assay ca…
Bamidele J, Abiodun O, Sodeinde K, Daniel O
Background Tuberculosis is still a major public health concern that affects millions of people worldwide. Despite the fact that tuberculosis has a well-established treatment, little attention is paid to the quality of life of TB patients on treatment. Poor quality of life has bee…
Njoku Oluomachi Leticia, Iyanda Ayobola Abolape
…n (Fe), and selenium (Se)—in newly diagnosed drug-sensitive tuberculosis (DSTB) and drug-resistant tuberculosis (DRTB) patients compared to a control group without tuberculosis admitted in selected health facilities in Oyo State, Nigeria. Methodology: Over the course of four mont…
Chidambaram V, Tun NL, Majella MG, Ruelas Castillo J, Ayeh SK, et al.
Background Although the incidence of tuberculosis is higher in men than in women, the relationship of sex with tuberculosis treatment outcomes has not been adequately studied. Methods We performed a retrospective cohort study and a systematic review and meta-analysis of observati…
Chabala C, Turkova A, Thomason MJ, Wobudeya E, Hissar S, et al.
Background Tuberculosis (TB) in children is frequently paucibacillary and non-severe forms of pulmonary TB are common. Evidence for tuberculosis treatment in children is largely extrapolated from adult studies. Trials in adults with smear-negative tuberculosis suggest that treatm…
Dooley KE, Kaplan R, Mwelase N, Grinsztejn B, Ticona E, et al.
Background The concurrent treatment of tuberculosis and human immunodeficiency virus (HIV) is challenging, owing to drug interactions, overlapping toxicities, and immune reconstitution inflammatory syndrome (IRIS). The efficacy and safety of dolutegravir (DTG) were assessed in ad…
S. N. Demidik, С. Б. Вольф, E. N. Alekso
Background. Tuberculosis influences female health significantly. Aim of the study: to analyze social and clinical characteristics of tuberculosis in women with different mycobacterium tuberculosis drug susceptibility residing in Grodno region and to assess the effectiveness of th…
Peetluk LS, Rebeiro PF, Cordeiro-Santos M, Kritski A, Andrade BB, et al.
Background Weight change may inform tuberculosis treatment response, but its predictive power may be confounded by human immunodeficiency virus (HIV). Methods We prospectively followed up adults with culture-confirmed, drug-susceptible, pulmonary tuberculosis receiving standard 4…
Yun YJ, Lee JS, Yoo JC, Cho E, Park D, et al.
…gs used in combination chemotherapies against Mycobacterium tuberculosis, and its use has greatly shortened the duration of chemotherapy for the successful treatment of drug-susceptible tuberculosis. Compensatory mutations have been identified in rpoC that restore the fitness of …
Mukunda Prasad Kafle
Treatment of Mycobacterium tuberculosis infection (tuberculosis disease) involves the use of multiple antimicrobials over several months. Therapy directed against tuberculosis (anti-tubercular therapy, or ATT) consists of rifampicin and isoniazid given daily for 6 months and pyra…
Ko EM, Min J, Kim H, Jeong JA, Lee S, et al.
…anscriptomic analysis of clinical isolates of Mycobacterium tuberculosis collected from patients with drug-susceptible tuberculosis (DS-TB). The clinical isolates were categorized based on treatment duration: standard 6 months or >6 months. Methods Study participants were recruit…
Shurygina AS, Zabolotnykh NV, Vinogradova TI, Vitovskaya ML, Dogonadze MZ, et al.
The steady rise of drug-resistant tuberculosis (TB), which renders standard therapy regimens ineffective, necessitates the development of innovative treatment approaches. Immunotherapeutic vaccines have the potential to effectively regulate the anti-TB immune response and enhance…
Daniel W Fitzgerald, MD, Carl Nathan, MD, Jean William Pape, MD
…(NTZ) will cause a significant decrease in the number of M. tuberculosis bacteria in sputum after 14 days of treatment. The study is being conducted at the GHESKIO Centers in Port au Prince Haiti This is a prospective randomized two-arm 14-day, early bactericidal activity study …