Showing 76–91 of 91 documents
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Sharma JB, Sharma SK, Dharmendra S, Singh UB, Kumar S, et al.
Background & objectives Female genital tuberculosis (FGTB) is an important variety of extrapulmonary TB causing significant morbidity, especially infertility, in developing countries like India. The aim of this study was to evaluate the laparoscopic findings of the FGTB. Methods …
Centre Hospitalier Universitaire Saint Pierre
Objective Prospectively describe the kinetics of 18F-FDG uptake of extrapulmonary TB after two months and at the end of TB treatment in HIV patients. Evaluate 18F-FDG-PET/CT as a TB treatment response monitoring tool. Design The investigators performed baseline FDG-PET/CT, anoth…
Salim Yusuf, M.D.
Human immunodeficiency virus (HIV) infection puts people at risk of opportunistic infections, such as tuberculosis. In Africa, the HIV epidemic has resulted in an increase in the number of cases of tuberculosis affecting various parts of the body, including the membrane surroundi…
Soumya Swaminathan, MD MNAMS
Title: Randomized clinical trial to assess the efficacy of short course intermittent regimens for the treatment of HIV-associated tuberculosis Phase: Phase III trial Population: 300 HIV positive patients with tuberculosis. Number of Sites:Four 1. Tuberculosis Research Centre,…
Gonzalo Alvarez, MD
The purpose of this study is to determine if 30-day survival will be improved with addition of prednisone to standard tuberculosis (TB) therapy. Tuberculosis (TB) is the leading cause of death in people infected with HIV worldwide. South Africa has one of the highest rates of tu…
David Boulware, MD
This two-stage study will compare consented research participants with tuberculous meningitis receiving BPaLMZ to controls receiving SOC of rifampicin (R), isoniazid (H), pyrazinamide (Z), and ethambutol (E), known as RHZE.
Prokešová Nikola, Valha Petr, Velemínský Miloš, Vítková Pavla, Stehlíková Adéla
Objective Description of a case of extrapulmonary genital tuberculosis of the uterine cervix in a postmenopausal patient. Case report A 66-year-old patient with a history of metrorrhagia, an ulcerated process in the area of the uterine cervix and vagina, with infiltration of para…
François Spertini
This is a dose escalating and a paired-placebo design study to describe the safety and immunogenicity profile of candidate TB vaccine ChAdOx1 85A given by aerosol inhaled vaccination versus intramuscular (IM) vaccination in adult healthy volunteers. It is postulated that the aer…
Juna Musa, Masum Rahman, Abu Bakar Siddik, Samar Ikram, Ilir Ahmetgjekaj, et al.
A paradoxical response is a clinical or radiological deterioration of existing or new lesions in tuberculosis patients following treatment. Female gender, HIV infection, length of illness are all known potential risk factors. However, the likelihood of developing a paradoxical re…
Suttels V, Du Toit JD, Fiogbé AA, Wachinou AP, Guendehou B, et al.
Point-of-care ultrasound (POCUS) is an increasingly accessible skill, allowing for the decentralization of its use to nonspecialist healthcare workers to guide routine clinical decision-making. The advent of ultrasound-on-a-chip has transformed the technology into a portable mobi…
Helen McShane
This study is designed to evaluate the safety of MVA85A in healthy volunteers in the UK who are latently infected with M.tb. A single vaccination with MVA85A, when administeredat a dose of 5 x 107pfu intradermally, is safe in both mycobacterially naïve individuals and those previ…
Anne BOURGARIT, MD, PhD
Tuberculous paradoxical reactions (PR) are immune reactions occurring during the course of antituberculous treatment and leading to a worsening of tuberculous symptoms after an initial improvement. This phenomenon has very extensively studied in HIV infected patients where it cor…
Stephen Gordon, MD
Despite tremendous efforts, an effective tuberculosis (TB) vaccine remains elusive. TB continues to infect and kill many. In 2021, TB infected more than 10 million and killed 1.6 million people. To date, the M.bovis bacille Calmette Guerin (BCG) is the only licensed vaccine again…
Rovina Ruslami, M.D., PhD
Tuberculous (TB) meningitis is the most severe manifestation of TB infection, leaving up to 50% of patients dead or neurologically disabled. Current treatment is similar to treatment of lung TB, although penetration of some antibiotics into the brain is poor and the immune-pathol…
Virupaksha Ajjammanavar, Sowmya Koteshwara, Megha Annaiah Hr, Jayashree S
Tuberculosis (TB) peritonitis is one of the least common causes for puerperal fever. We report a case of pregnant woman in the early 20s who had a preterm vaginal delivery. Following delivery, the patient had persistent episodes of low-grade fever, gradual loss of appetite and lo…
Fabrice Bonnet, M.D., Ph.D.
INTENSE-TBM is randomized controlled, phase III, multicenter, 2 x 2 factorial plan superiority trial assessing the efficacity of two interventions to reduce mortality from tuberculous meningitis (TBM) in adolescents and adults with or without HIV-infection in sub-Saharan Africa: …