Showing 76–100 of 200 documents
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Devraj Regmi, Purnakala Regmi, Sarbada Shrestha
Background: Delay in the diagnosis of tuberculosis can lead to an increased inactivity period, delayed treatment, and increased disease severity. The objective of this study was to identify the magnitude of the delay and the factors causing a delay in the diagnosis of Tuberculosi…
Salih Cesur
Tuberculosis is an infectious disease whose diagnosis dates back to very early ages, which still maintains its importance in the world and in our country, can be treated and prevented with preventive (prophylactic) treatment. It is one of the leading causes of death in HIV/AIDS p…
Velasco-Arnaiz E, Pérez E, Henares D, Fernández-López A, Valls A, et al.
…lcitonin (PCT) levels have been reported in adult pulmonary tuberculosis (TB) but have not been previously investigated in children. We aimed to assess PCT levels at diagnosis of TB in young children in a low-burden setting. In a cross-sectional observational study in a referral …
Christian Diamant Mossoro‐Kpinde, Honorat Nouzoukem, Marcel Mbeko Simaléko, Nina Esther Ngoyi Ontsira, Hermione Dahlia Mossoro-Kpinde, et al.
Background and Objective: Tuberculosis is one of the leading causes of morbi-mortality, especially in developing countries, due to delayed diagnosis and management. The goal of this study is to assess the contribution of lipoarabinomannan (LAM) in improving tuberculosis (TB) diag…
Ayling Sanjaya
The diagnosis of pediatric TB is based on history taking, clinical symptoms, physical examination and support. In recent years the role of microRNA (miRNA or miR) has become a concern for researchers as biomarkers of diagnosis and therapy in TB in adults and children. MicroRNA is…
Concepcion NDP, Laya BF, Andronikou S, Abdul Manaf Z, Atienza MIM, et al.
Tuberculosis (TB) remains a global health problem and is the second leading cause of death from a single infectious agent, behind the novel coronavirus disease of 2019. Children are amongst the most vulnerable groups affected by TB, and imaging manifestations are different in chi…
Chatterjee S, Banta A
Introduction Pediatric spinal tuberculosis is characterized by rapid bone destruction and carries the risk of rapid onset neurological deficits and severe deformity of the spine. Behavior of spinal deformity over time is affected by growth of spine. Owing to this dynamic behavior…
Santiago Atehortúa-Muñoz, Andrea Cardona-Moreno, Laura Niño-Quiroga, Javier Orlando Contreras-Ortiz, Catalina Arango-Ferreira
Abstract Objective Diagnosis of pulmonary tuberculosis (PTB) in pediatrics is a challenge due to the paucibacillary condition of the disease in this population, low sputum expectoration, and diverse unspecific symptomatology. Mycobacterial isolation through culture remains a prio…
Battaglia CSP, Parente AAAI, Luiz RR, Aurilio RB, Pinheiro MAS, et al.
Objectives To evaluate the contribution of Ultra to the diagnosis of pediatric pulmonary tuberculosis (PTB). Methods We analyzed prospective data from children and adolescents with presumed PTB whose specimens were tested with Ultra between January 2020 and December 2022. Diagnos…
Heather J. Zar, Mark P. Nicol
Pediatric tuberculosis is a global concern, with children estimated to account for 10% to 15% of the overall case load, representing almost 1 million cases annually. However, modeling estimates indicate that only 30% of childhood tuberculosis cases are diagnosed and notified.1 Di…
Mgode GF, Cox CL, Mwimanzi S, Mulder C
Background Tuberculosis (TB) diagnosis in children is a challenge with up to 94% of children with TB treated empirically in TB high-burden countries. Therefore, new diagnostic tests are needed for TB diagnosis. We determined the performance of trained rats in the diagnosis of ped…
Sushil Kumar Kabra
Diagnosis of Tuberculosis in children is challenging. Major challenge is because of difficulty in obtaining representative airway samples and paucibacillary nature of illness. Significant improvement occurred over past few years. However, the sensitivity and specificity of labora…
Yalçın Kara
Tuberculosis is an infectious disease caused by the Mycobacterium tuberculosis bacteria with high mortality and morbidity. Especially, delay in diagnosis and treatment of childhood tuberculosis causes an increase in adult tuberculosis. According to the World Health Organization, …
Jakhar S, Bitzer AA, Stromberg LR, Mukundan H
Tuberculosis (TB) is a major public health concern for all ages. However, the disease presents a larger challenge in pediatric populations, partially owing to the lack of reliable diagnostic standards for the early identification of infection. Currently, there are no biomarkers t…
Zhu J, Chen N, Shang Y, Feng Y
… distress syndrome (ARDS) is a rare complication of miliary tuberculosis, particularly in pediatric patients. Comorbidities and delayed diagnosis can worsen the prognosis of patients with miliary tuberculosis. A 12-year-old girl presented with fever for 20 days, and cough and tac…
Elfarissi MA, Dahamou M, Dehneh Y, Lhamlili M, Khoulali M, et al.
Background Pediatric sellar-suprasellar tuberculosis is a rare form of tuberculosis that affects the pituitary gland and surrounding areas in the brain. It can be difficult to diagnose based on clinical and radiological signs alone, as they can be similar to other pituitary masse…
Min Yu, Qi-Jun Jiang, Yuqing He, Fei Zhao, Tang-Ming Jin, et al.
Clinical manifestations of pediatric pulmonary tuberculosis (PTB) are atypical, making diagnosis challenging. This study aims to analyze the clinical characteristics of PTB to provide constructive suggestions for the diagnosis of PTB. A retrospective analysis was conducted on ped…
Marcy O, Goyet S, Borand L, Msellati P, Ung V, et al.
Background There is no gold standard for tuberculosis diagnosis in children. Clinical Case Definitions for Classification of Intrathoracic Tuberculosis in Children were proposed by international experts in 2012 and updated in 2015. We aimed to compare the 2012 and 2015 Clinical C…
M.J. Cavaco, Sofia Giusti Alves, L. Mateus, André Nunes, Ricardo Cordeiro, et al.
<b>Introduction:</b> Early diagnosis of tuberculosis (TB) is essential to achieve cure and to reduce disease transmission. Total diagnostic delay (TDD) can be divided in patient delay (PD - from symptoms onset to seeking a health care facility) and health system delay (HSD - from…
Alexandra R Linn, Andrew P. Steenhoff
…ground The WHO currently estimates that at least a third of pediatric and adolescent tuberculosis cases go untreated or incompletely treated each year. Many cases are detected but lost to follow-up due to underreporting to national or private surveillance systems. Methods We cond…
Ahang Hasan Mawlood
Background and objective: M. tuberculosis is one of the main causes of morbidity and mortality in many countries and is considered a priority global health problem. Although it is a curable disease, every year about nine million people develop active disease, and two million die …
Palmer M, Gunasekera KS, van der Zalm MM, Morrison J, Simon Schaaf H, et al.
…duction The chest radiograph (CR) remains a key tool in the diagnosis of pediatric tuberculosis (TB). In children with presumptive intrathoracic TB, we aimed to identify CR features that had high specificity for, and were strongly associated with, bacteriologically confirmed TB. …
Bayhan GI, Sayir F, Tanir G, Tuncer O
Background Pleural tuberculosis (TB) diagnosis is sometimes controversial because the microbiologic confirmation ratio is very low in pleural fluid. There are few pediatric pleural TB case series in the literature. Methods We retrospectively evaluated our TB cases below 18 years …
Agata Gierlotka, Ryszard Sordyl, Ireneusz Bielecki, Marek Mandera
… identify and evaluate the management options for pituitary tuberculosis in the pediatric population. **METHODS:** The study was conducted based on a comprehensive literature review using the PubMed, Cochrane Library, and ScienceDirect electronic databases. The following keyword…
Lucía Carratalà-Castro, Shilzia Munguambe, Belén Saavedra-Cervera, Petra de Haas, Alexander Kay, et al.
…ACKGROUND:** There has been a global pursuit to improve the diagnosis of tuberculosis in young children by applying diagnostic methods on accessible biospecimens such as stool. We aimed to conduct a systematic review on the accuracy of stool-based molecular tests for tuberculosis…