Showing 76–100 of 200 documents
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Naomi Hillery, Marva Seifert, Donald G. Catanzaro, Symone McKinnon, Rebecca E. Colman, et al.
…ral flow cell (XDR-LFC) to address this gap in tuberculosis diagnostics. </sec> <sec> <title>OBJECTIVE</title> This paper presents the protocol for a study that aims to document the conceptualization and design of this evaluation method for early dissemination while data collecti…
Kumari Neelam, Ira Sharma, Devinder Kumar, Kunal Goel, Virender Singh, et al.
… potential for permanent disability. Recent advancements in diagnostics, pharmacotherapy, and adjunctive treatments have shown promise for improving the outcomes of patients with OATB. This review summarizes the latest developments in the field, focusing on epidemiology, pathogen…
Thanadon Dokrungkoon, Tawatchai Chumponsuk, Kamol Suwannakarn, Orapan Sripichai, Popchai Ngamskulrungroj
**PURPOSE:** Drug-resistant tuberculosis (DR-TB) complicates treatment and requires diagnostic approaches capable of comprehensive resistance profiling of(MTB). This study evaluated the diagnostic performance of the Oxford Nanopore Technologies (ONT) custom TB-DR sequencing assay…
Seema rani
… new evidence-based approaches. The implementation of rapid diagnostics, patient-centered treatment plans, community education, and international collaboration has become pivotal in achieving long-term control and eventual elimination of drug-resistant TB. Through detailed case s…
Amelework Firomsa Wakuma
**BACKGROUND:** A serious infectious illness with a high morbidity and death rate worldwide, tuberculosis (TB) is more prevalent in low- and middle-income nations. Although there are a number of diagnostic techniques, the most only address tuberculosis in the lung and ignore drug…
Zunt JR
Purpose of review This article details the epidemiology and clinical manifestations of central nervous system (CNS) tuberculosis (TB), provides guidance for diagnostic imaging and CSF testing, and recommends treatment strategies for tuberculous meningitis and other forms of CNS T…
Leonid Lavrenchuk, Tatiana Minogina, Diana Vakhrusheva, Sergey Skornyakov, Л. А. Голубева, et al.
Purpose . Improvement of algorithms of etiologic diagnostics of tuberculous spondylitis in modern realities of mycobacteria drug resistance and combined viral infections. Materials and methods . Laboratory results of diagnostic materials obtained from 300 patients diagnosed with …
Rahman SMM, Nasrin R, Rahman A, Ahmed S, Khatun R, et al.
Background Rapid and early detection of drug susceptibility among multidrug-resistant tuberculosis (MDR-TB) patients could guide the timely initiation of effective treatment and reduce transmission of drug-resistant TB. In the current study, we evaluated the diagnostic performanc…
Barilar I, Fernando T, Utpatel C, Abujate C, Madeira CM, et al.
Background In 2021, an estimated 4800 people developed rifampicin-resistant tuberculosis in Mozambique, 75% of which went undiagnosed. Detailed molecular data on rifampicin-resistant and multidrug-resistant (MDR) tuberculosis are not available. Here, we aimed at gaining precise d…
Anisha Shree Venugopal, Safana Safreen Sirajudeen, BEGAYIM SOVETBEKOVNA MUSAEVA
…es on therapeutic outcomes, epidemiology, pathogenesis, and diagnostics. Results: PTB typically presents with persistent cough, fever, night sweats, weight loss, and hemoptysis. Diagnosis relies on sputum microscopy, culture, rapid molecular tests, and imaging. Drug-sensitive PTB…
Getachew E, Adebeta T, Gebrie D, Charlie L, Said B, et al.
Background Multidrug and extensively drug-resistant tuberculosis (M/XDR-TB) pose major threats to global health. Diagnosis accuracy and delay have been the major drivers for the upsurge of M/XDR-TB. Pyrosequencing (PSQ) is a novel, real-time DNA sequencing for rapid detection of …
Anisha Shree Venugopal, Safana Safreen Sirajudeen, BEGAYIM SOVETBEKOVNA MUSAEVA
…es on therapeutic outcomes, epidemiology, pathogenesis, and diagnostics. Results: PTB typically presents with persistent cough, fever, night sweats, weight loss, and hemoptysis. Diagnosis relies on sputum microscopy, culture, rapid molecular tests, and imaging. Drug-sensitive PTB…
Borham M, Oreiby A, El-Gedawy A, Hegazy Y, Khalifa HO, et al.
Bovine tuberculosis is a serious infectious disease affecting a wide range of domesticated and wild animals, representing a worldwide economic and public health burden. The disease is caused by Mycobacterium bovis and infrequently by other pathogenic mycobacteria. The problem of …
Erick Persson Jeffry, Charles Sanjaya Seikka
…rce environments. They emphasize the importance of improved diagnostics and the integration of new therapeutic strategies, while also addressing the financial barriers associated with MDR-TB treatment. (Kolloli & Subbian, 2017) shift the focus to host-directed therapies, argu…
Hillery N, Seifert M, Catanzaro DG, McKinnon S, Colman RE, et al.
…ral flow cell (XDR-LFC) to address this gap in tuberculosis diagnostics. Objective This paper presents the protocol for a study that aims to document the conceptualization and design of this evaluation method for early dissemination while data collection and analysis are ongoing.…
Jenifer A Otieno, Lisa Malesi Were, Vittoria Lutje, Katie Scandrett, Yemisi Takwoingi, et al.
**RATIONALE:** The World Health Organization (WHO) recommends rapid nucleic acid amplification tests (NAATs), such as Xpert MTB/RIF Ultra, as the initial diagnostic test for tuberculosis (TB). However, the effect of these tests on key health outcomes is not well-established. **O…
Deshpande A, Likhar R, Khan T, Omri A
…niques, such as Whole-Genome Sequencing (WGS), CRISPR-based diagnostics and their impact on identifying and managing drug-resistant TB. Additionally, we discuss artificial intelligence applications, current treatment strategies, challenges in managing MDR-TB and XDR-TB, and the g…
Shadow Bee
…rint highlights the importance of expanding rapid molecular diagnostics beyond rifampicin resistance alone, particularly given rising global rates of second-line drug resistance. The authors argue that Xpert MTB/XDR could serve as a practical, near–near-point-of-care diagnostic t…
Shadow Bee
…rint highlights the importance of expanding rapid molecular diagnostics beyond rifampicin resistance alone, particularly given rising global rates of second-line drug resistance. The authors argue that Xpert MTB/XDR could serve as a practical, near–near-point-of-care diagnostic t…
Phelan JE, O'Sullivan DM, Machado D, Ramos J, Oppong YEA, et al.
Background Mycobacterium tuberculosis resistance to anti-tuberculosis drugs is a major threat to global public health. Whole genome sequencing (WGS) is rapidly gaining traction as a diagnostic tool for clinical tuberculosis settings. To support this informatically, previous work …
Cancino-Muñoz I, Moreno-Molina M, Furió V, Goig GA, Torres-Puente M, et al.
Understanding why some multidrug-resistant tuberculosis cases are not detected by rapid phenotypic and genotypic routine clinical tests is essential to improve diagnostic assays and advance toward personalized tuberculosis treatment. Here, we combine whole-genome sequencing with …
Zifodya JS, Kreniske JS, Schiller I, Kohli M, Dendukuri N, et al.
Background Xpert MTB/RIF and Xpert MTB/RIF Ultra (Xpert Ultra) are World Health Organization (WHO)-recommended rapid tests that simultaneously detect tuberculosis and rifampicin resistance in people with signs and symptoms of tuberculosis. This review builds on our recent extensi…
Gao Y, Zhang Z, Deng J, Mansjö M, Ning Z, et al.
Objectives The implementation of rapid and reliable drug susceptibilities diagnosis is fundamental for effective treatment of multidrug-resistant tuberculosis(MDR-TB). The present study aimed to assess the diagnostic performance of the 2nd-version GenoType MTBDRsl kit as well as …
Kerri Viney, Fuad Mirzayev, Linh Nguyen, Medea Gegea, Matteo Zignol
…e to determine how recent changes in treatment regimens and diagnostics for drug-resistant TB might affect the definition of XDR-TB and discuss options for changing it. <b>Methods:</b> The latest WHO policy recommendations on treatment regimens and diagnostics for drug resistant …
Deepak Kajla, Veerta Sharma, Ashi Mannan, Tanveer singh, Pankaj Kumar Singh
…hes in MDR-TB diagnosis and management, including molecular diagnostics, novel oral drugs, and adjunctive therapies such as nutritional and traditional support systems. Results: Recent WHO guidelines emphasize early detection using advanced molecular techniques and the use of rep…