Showing 76–100 of 200 documents
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Ismail IM, Kibballi Madhukeshwar A, Naik PR, Nayarmoole BM, Satyanarayana S
Background In India, ensuring all Persons with Presumptive TB (PPTB) undergo TB diagnostic tests and initiating all diagnosed TB patients on treatment are two major implementation challenges. Objectives In a coastal district of Karnataka state, South India, to (1) determine the n…
Paul K. Drain, MD, MPH, FACP, Douglas Wilson, MD
…nce LAM test, or to share with partners developing novel TB diagnostics, including new LAM antibodies. The project will be coordinated at the University of Washington, and conducted in partnership with clinical research partners in South Africa, including Umkhuseli Innovation and…
Zou X, Zhu Y, Hu Q, Qi Q, Hua H, et al.
Background To investigate the diagnostic value of bronchial ultrasound-guided transbronchial lung biopsy (EBUS-TBLB) in tuberculous peripheral pulmonary lesions. Methods A total of 770 patients who completed CT imaging and ultrasound bronchoscopy were retrospectively analyzed. Al…
Ibrahim Adamu, Nura Umaru, Adamu Mohammed Sani, Ali Adamu Abdullahi, Jabir Hamza Adamu, et al.
**PURPOSE:** Pulmonary tuberculosis (PTB) continues to be a major public health burden, a situation exacerbated by significant diagnostic gaps. Conventional testing relies heavily on sputum samples, but many patients are unable to produce adequate and qualitative sputum. This lim…
Tushar Garg, Vivek Gupta, Dyuti Sen, Madhur Verma, Miranda Brouwer, et al.
…ompanied by the CHW to a designated government facility for diagnostics. Those with a confirmed TB diagnosis were put on treatment by the CHW and followed-up till treatment completion. All services were provided free of cost and patients were supported throughout the care pathway…
Wenhua Gu, Bo Yang, Tongyangzi Zhang, Yiqing Zhu, Wanzhen Li, et al.
Background Finding a simple, effective and rapid diagnostic method to improve the diagnosis of gastroesophageal reflux-induced chronic cough (GERC) is indicated. Our objective was to determine the diagnostic value of the pepsin concentration in saliva and induced sputum for GERC.…
Peewara Thampanyawat, Patsharaporn T. Sarasombath, Anupop Jitmuang, Kamonthip Kunwipakorn
Abstract Background The prevalence of Pneumocystis pneumonia (PCP), primarily affecting immunocompromised individuals, notably those without HIV infection, has been increasing. Diagnosing PCP is challenging due to the lack of a standard definition. Its diagnosis mainly relies on …
Takashi Okuma, Eri Hagiwara, Ryo Okuda, T. Oda, Ryota Otoshi, et al.
Abstract Background: In asymptomatic patients with pulmonary Mycobacterium avium complex (MAC) disease, sputum culture testing can be challenging, often leading to difficulty in diagnosis. To investigate the usefulness of gastric juice culture, this study examined the clinical ch…
Rahma Isti Kusyadi, Lita Diah Rahmawati, Prastuti Asta Wulaningrum
**INTRODUCTION:** Poncet's disease (PD) is a rare form of TB-associated reactive arthritis, presents a major diagnostic challenge due to its close resemblance to rheumatoid arthritis and tuberculous septic arthritis. A clear diagnostic workflow is essential to support clinical de…
Holtgrewe LML, Jain S, Dekova R, Broger T, Isaacs C, et al.
Rapid and accurate point-of-care (POC) tuberculosis (TB) diagnostics are crucial to bridge the TB diagnostic gap. Leveraging recent advancements in COVID-19 diagnostics, we explored adapting commercially available POC SARS-CoV-2 tests for TB diagnosis in line with the World Healt…
Mercy Corps Pakistan
…ity, cost-effectiveness, and turnaround time of the new NAT diagnostics compared to the Xpert Ultra platform. The strategy will involve both quantitative and qualitative research methods. Quantitative data will be collected and analyzed regarding the cost per test and the time ta…
John Abel, Surya Dharun
…undetected transmission within herds. Advances in molecular diagnostics and non-invasive sampling strategies in human tuberculosis have demonstrated that Mycobacterium tuberculosis DNA can be reliably detected from oral surfaces, including tongue swabs, using PCR-based methods. T…
John Abel, Surya Dharun
…undetected transmission within herds. Advances in molecular diagnostics and non-invasive sampling strategies in human tuberculosis have demonstrated that Mycobacterium tuberculosis DNA can be reliably detected from oral surfaces, including tongue swabs, using PCR-based methods. T…
Padingani M, Kumar A, Tripathy JP, Masuka N, Khumalo S
Introduction While there are many studies assessing the pre-treatment loss to follow-up (LFU) among tuberculosis patients in public sector, there is no evidence from private-for-profit health sector and pre-diagnostic LFU from Zimbabwe. We aimed to assess the gaps in the cascade …
J Stübler, L Denkmayr, M J Studnicka, P Kaiser-Krug
Abstract Rationale Endobronchial ultrasound-guided (EBUS) TBNA is the current standard for minimally invasive sampling of mediastinal/hilar lymph nodes. However, cytological specimen may not be sufficient for diagnosis requiring preserved tissue architecture. EBUS-guided TBINCB h…
Nichols BE, de Nooy A, Cassim N, Hans L, da Silva MP, et al.
Introduction To ensure there is adequate investment into diagnostics, an understanding of the magnitude of impact and return on investment is necessary. We, therefore, sought to understand the health and economic impacts of the molecular diagnostic programme in South Africa, to d…
Yating Zhao, Longting Du, Junli Song, Wei Sun, Yili Chen, et al.
…Our findings provide actionable solutions for optimizing TB diagnostics in diverse healthcare ecosystems, aligning with the WHO's End TB Strategy to ensure equitable access to rapid diagnostics.
Niti Sureka, Smriti Sharan, Charanjeet Ahluwalia, Sana Ahuja, Sunil Ranga
**BACKGROUND:** Pulmonary diseases represent a significant global health challenge, underscoring the need for accurate diagnostic methods to ensure effective management. Bronchoalveolar lavage (BAL) is an essential diagnostic tool, providing valuable insights into various lung co…
Fahriye Hakan-Groen
The Dutch national uveitis guideline advises on the diagnostic work-up of uveitis patients. However, some of the included diagnostic tests as well as their value in the work-up for new uveitis patients were so far not systematically studied. \nWith the rise of novel diagnost…
Dionysius B. P. Manyakori, Andri Danika
Abstract Wrist tuberculosis (TB) is a rare manifestation of osteoarticular TB that presents substantial diagnostic challenges, particularly in TB-endemic regions. Its insidious onset and nonspecific clinical manifestations frequently lead to misdiagnosis and delayed treatment. Th…
Ntinginya NE, Kuchaka D, Orina F, Mwebaza I, Liyoyo A, et al.
…portunities to maximise uptake and utilisation of molecular diagnostics in routine healthcare settings. Methods Using the implementation of WHO approved TB diagnostics, Xpert Mycobacterium tuberculosis /rifampicin (MTB/RIF) and Line Probe Assay (LPA) as a benchmark, we evaluated …
Cristina Blanco‐Vázquez, Marta Alonso‐Hearn, Ramón A. Juste, María Canive, Tania Iglesias, et al.
Bovine paratuberculosis (PTB) is a chronic granulomatous enteritis, caused by Mycobacterium avium subsp. paratuberculosis (MAP), responsible for important economic losses in the dairy industry. Current diagnostic methods have low sensitivities for detection of latent forms of MAP…
Wang B, Wang Q, Li M, Yu J, Jiang F, et al.
…t yet discussed in current literature as a means for TB-IAI diagnostics. Here we describe a cohort of patients with TB-IAI diagnosed by mNGS show high efficiency of mNGS for detection of this pathology and present a clinical algorithm supplementing conventional methods for TB-IAI…
Zou X, Xu H, Hu Q, Qi Q, Ma X, et al.
Background Microbiological diagnosis of pulmonary tuberculosis (PTB) is hampered by a low pathogen burden, low compliance and unreliable sputum sampling. Although endobronchial ultrasound-guided transbronchoscopic lung biopsy (EBUS-TBLB) has been found to be useful for the assess…
Joyce Mulenga, Lonia Mwape, Patricia Katowa-Mukwato
Background Tuberculosis (TB) and human immunodeficiency virus (HIV) constitute the main burden of infectious disease in resource-limited Countries6. Persons infected with HIV are particularly susceptible to tuberculosis, both from the reactivation of latent infection and from new…