Showing 76–100 of 200 documents
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Sosina Ayalew, Teklu Wegayehu, Biniam Wondale, Dawit Halu Alemayehu, Dawit Kebede, et al.
…less-invasive complement to existing fine needle aspiration diagnostics.
Yan Hu, Chao Quan, Yuanyuan Zhou, Shangyan Liang, Xuan Wang, et al.
**BACKGROUND:** The differential diagnosis between Tuberculosis (TB) and Non-tuberculous Mycobacteria (NTM) has historically been constrained by the inadequate sensitivity and specificity of current diagnostic methods. Furthermore, distinguishing between Active Tuberculosis (ATB)…
Yulia A. Yarovaya, M. E. Lozovskaya, Yulia A. Pobezhimova, E. B. Vasilieva, Л. В. Клочкова, et al.
BACKGROUND: Ultrasound diagnostics of abdominal organs is an early method of detecting functional and structural changes in tuberculosis infection before the manifestation of clinical manifestations. Currently, there are no uniform criteria for interpreting the sonographic pathol…
Halliday A, Masonou T, Tolosa-Wright MR, Guo Y, Hoang L, et al.
Background Diagnosis of paucibacillary tuberculosis (TB) including extrapulmonary TB is a significant challenge, particularly in high-income, low-incidence settings. Measurement of Mycobacterium tuberculosis (Mtb)-specific cellular immune signatures by flow cytometry discriminate…
Dinesh Rotake, A. Parakh, Shiv Govind Singh, Jitendra B. Zalke
An insilico diagnostic probes is designed for the detection of latent Tuberculosis caused by Mycobacterium Tuberculosis. Identification of a specific target is required to diagnose the condition of latent Tuberculosis. Till date, there is no specific detection of latent Tuberculo…
Warangkana Keeratichananont, Theerapat Buppodom, Nawamin Pinpathomrat, Suriya Keeratichananont, Bunya Seeyankem, et al.
In the absence of a definitive gold standard for diagnosing latent tuberculosis infection (LTBI) in healthcare workers (HCWs), alternative specific biomarkers are needed. This longitudinal cohort study with baseline testing evaluated the diagnostic performance of stimulated plasm…
Sudhasini Panda, Jeffrey Morgan, Catherine Cheng, Mayuko Saito, Robert H. Gilman, et al.
Abstract The challenge in advancing tuberculosis (TB) diagnostics and vaccines arises from our limited understanding of diverse Mtb antigens triggering distinct T cell responses in spectrum of TB infection. We addressed this with a comprehensive analysis, screening 20,610 Mtb-der…
L. Kassegne, Philippe Fraisse
<title>Abstract</title> Background Most tuberculosis (TB) cases in high-income countries occur in foreign-born people, most of them coming from high incidence countries. However, migrants return more or less frequently to their birth countries. The aim of the study was to estimat…
Qiangsen Zhong, Xiaochun Wang, Yun Xu, Runlin Wang, Mingming Zhou, et al.
Tuberculosis (TB) is the leading cause of death in global infectious diseases, and precise diagnosis and preventive intervention of latent tuberculosis infection (LTBI) are important to end the TB epidemic. In this study, we explored the diagnostic value of five Mycobacterium tub…
Araujo Z, Macias-Segura N, Lopez-Ramos JE, De Waard JH, Vanegas M, et al.
Introduction Confirmation of tuberculosis (TB) cases in endemic TB settings is a challenge; obtaining fast and cheap, though accurate, diagnostic tools such as biomarkers is thus urgently needed to enable the early detection of TB. This paper evaluates the diagnostic accuracy of …
Angela Hidalgo-Gajardo, Bryan Mangui, Carla Villavicencio, Jorge R Toledo, Frank Camacho
Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (MTB), Bacille Calmette-Guérin (BCG) is the only licensed vaccine for tuberculosis, but it provides limited and inconsistent protection against pulmonary TB in adults. Furthermore, current diagno…
Swindells S
…apy and early antiretroviral therapy (ART). Rapid molecular diagnostics have approximately 88% sensitivity and 98% specificity for identifying active TB. ART should be started early in patients with TB. A number of ART regimens are recommended in co-treatment that minimize the ri…
Jingyan Zhang, Qiangsen Zhong, Xiaochun Wang
Early and timely diagnosis is crucial for reducing the transmission of tuberculosis.In this study, we constructed and expressed PhoY2, a persistent infection related antigen of Mycobacterium tuberculosis and evaluated its potential as a diagnostic target through population experi…
Marcus Bauer, Anke Hildebrandt
Background: Dyspnea is a common clinical symptom and cause of outpatient and inpatient presentations to the clinic. Diagnostic and therapeutic challenges appear, when additional diseases appear that are themselves associated with subjectively perceptible dyspnea. We report on a y…
Yang Y, Zhang F, Shi H, Zhu Z, Zhou Y, et al.
Background Interferon-gamma release assay (IGRA) for tuberculosis (TB) remains limited in its ability to discriminate between active TB (ATB) and latent TB infection (LTBI). Activation markers on host T and NK cells are currently considered to be promising markers in the diagnosi…
Mirzaei R, Babakhani S, Ajorloo P, Ahmadi RH, Hosseini-Fard SR, et al.
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), has been the world's driving fatal bacterial contagious disease globally. It continues a public health emergency, and around one-third of the global community has been affected by latent TB infection (LTBI). This is m…
Jiang Y, Yan L, Zhou B, Hong J, Tan H, et al.
Background Exosome is a small extracellular vesicle with a diameter of 30 to 150 nm that is secreted by cells. Mtb and other bacteria can also secrete extracellular vesicles, which carry characteristics and information about the pathogen. Here, we compare the concentration of exo…
Qiu B, Liu Q, Li Z, Song H, Xu D, et al.
Objectives With a marginally effective vaccine and no significant breakthroughs in new treatments, a sensitive and specific method to distinguish active tuberculosis from latent tuberculosis infection (LTBI) would allow for early diagnosis and limit the spread of the pathogen. Th…
Imoto S, Suzukawa M, Takeda K, Motohashi T, Nagase M, et al.
Tuberculosis (TB) remains a serious health concern globally. QuantiFERON-TB (QFT) is a diagnostic tool for TB detection, and its sensitivity is reduced in immunocompromised hosts with low T lymphocyte counts or abnormal T cell function. This study aimed to evaluate the correlatio…
Zhang Z, Wang Y, Zhang Y, Geng S, Wu H, et al.
Background Tuberculosis (TB) is one of the most infectious diseases caused by Mycobacterium tuberculosis ( M. tb ), and the diagnosis of active tuberculosis (TB) and latent TB infection (LTBI) remains challenging. Methods Gene expression files were downloaded from the GEO databas…
Felix Bongomin, Phillip Ssekamatte, Ronald Olum, Diana Sitenda, Davis Kibirige, et al.
**BACKGROUND:** Pregnancy modulates immune responses against() infection. Cytokines, including interleukin-2 (IL-2), play a crucial role incontainment, mainly by inducing the proliferation of T cells. However, the role of IL-2 in latent tuberculosis (TB) infection (LTBI) screenin…
Yan WJ, Zhou HY, Yan H
Tuberculosis (TB) is an airborne infection caused by Mycobacterium tuberculosis that usually affects the lungs. Timely treatment of active TB, diagnosis and prevention of latent TB are very important. However, extrapulmonary TB affects almost any tissues around the eye and orbit,…
Wang S, He L, Wu J, Zhou Z, Gao Y, et al.
Mycobacterium tuberculosis ( M. tuberculosis ) infection in humans can cause active disease or latent infection. However, the factors contributing to the maintenance of latent infection vs. disease progression are poorly understood. In this study, we used a genome-wide RNA sequen…
Yuehong Xu, Xiaoying Li, Pu Liao, Changchun Niu
Abstract Background Our study aims to identify novel diagnostic biomarkers for distinguishing different infection statuses of M. tuberculosis. Methods Differential genes (DEGs) of different infection statuses of M. tuberculosis from the GEO datasets were analyzed using GEO2R. The…
O.B. Pikas, M.A. Semeniuk
…culosis infection is recommended: history study, tuberculin diagnostics (quantiferon test), clinical, radiological and microbiological examination for timely detection of tuberculosis (or infection). The tuberculin Mantoux test and interferon-gamma release assays are useful for …