Showing 76–100 of 200 documents
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Longying Wang, Xiaojuan Cui, Tao Wang, Lei Xu, Mingqiu Mao, et al.
**BACKGROUND:** Tuberculosis (TB) is one of the most severe infectious diseases worldwide, making early and accurate diagnosis critical for improving patient outcomes. The interferon-gamma release assay (IGRA) is a commonly used diagnostic tool for TB. This study aimed to develop…
Abhipriyam Gahlowt, Mehvash Haider, Neetu Shree, Zeeba Shamim Jairajpuri, Ayan Kumar Das, et al.
Abstract Background: A number of laboratory-based diagnostic modules are available for the diagnosis of extrapulmonary tuberculosis (EPTB), which vary greatly in terms of sensitivity and specificity. Methods: In this cross-sectional study, we conducted a comparative evaluation of…
Agustin Iskandar, Maimun Zulhaidah Arthamin, Gilang Kusdinar, Kusworini Handono, Ery Olivianto, et al.
Introduction and Aim:Childhood tuberculosis (TB) remains a major problem worldwide.However, diagnosis of tuberculosis in children is often complicated by the difficulty in obtaining a proper sputum specimens and low sensitivity of the gold standard diagnostic test to confirm the …
Hernandez AV, de Laurentis L, Souza I, Pessanha M, Thota P, et al.
Objective This systematic review evaluated the diagnostic accuracy of Xpert MTB/RIF to detect tuberculous meningitis (TBM). Methods PubMed and five other databases were systematically searched through March 2019. All studies evaluating diagnostic accuracy of Xpert MTB/RIF on cere…
Abdugapparov F, Grigoryan R, Parpieva N, Massavirov S, Riskiyev A, et al.
Tuberculosis (TB) pleural effusion (TPE) is the second most common manifestation of extrapulmonary TB (EPTB), which remains a great diagnostic challenge worldwide. In Uzbekistan, there has been no formal evaluation of the actual practices of diagnosing and treating TPE. Our cohor…
Gupta V, Kulkarni V, H R, Dua G, Gupta A, et al.
Tuberculosis (TB) manifests in various forms, including extrapulmonary tuberculosis (EPTB), which poses diagnostic dilemmas due to its wide-ranging clinical presentations. When TB affects the bones of the hands and feet, it can present a diagnostic labyrinth for clinicians. In su…
Tiffeney Mann, Stephanie Minnies, Rishi K Gupta, Byron W P Reeve, Georgina Nyawo, et al.
**BACKGROUND:** Data on the diagnostic accuracy of blood RNA biomarker signatures for extrapulmonary tuberculosis are scarce. We aimed to address this question among people investigated for tuberculosis lymphadenitis and tuberculosis pericarditis. **METHODS:** This prospective, …
Е. В. Корж, Н. А. Подчос, Alexandr F. Zavgorodniy, Svetlana A. Iskevich
…im of the study is to analyze the reasons for the erroneous diagnostics of TB in the general health care institutions and identify ways to improve diagnostics. Materials and methods. 147 medical cards of inpatients who were in the Donetsk Republican Clinical Tuberculosis Hospital…
Murwan Mohamed Saeed, Laila Sulman AbdElrhman
Background: Tuberculosis is an infectious caseating granulomatous disease that cause by mycobacterium mainly mycobacterium tuberculosis and mycobacterium bovis, it is a systemic disease that effect any body organ, but mainly affect the lung. EHO classified tuberculosis into pulmo…
Dong Huu Khanh Trinh, Joseph Donovan, Ngoc My Nghiem, Thu Dang Anh, Nghia Ho Dang Trung, et al.
Abstract Background Diagnosis of tuberculous meningitis (TBM) is hampered by the lack of a gold standard. Current microbiological tests lack sensitivity and clinical diagnostic approaches are subjective. We therefore built a diagnostic model that can be used before microbiologica…
M.І. Sakhelashvili, Z.I. Pіskur, O.I. Sakhelashvili–Bil
Objective — to study the frequency and causes of diagnostic errors in primary pulmonary tuberculosis (PrPTB) in adults. Materials and methods. The frequency and causes of diagnostic errors in verifying PrPTB in adults were studied by analyzing the pathomorphosis aspect of a speci…
Kamponda M, Bickton FM, Mategula D, Nliwasa M, Kreuels B, et al.
Background Extra-pulmonary tuberculosis (EPTB) accounts for 15% of the 1.4 million patients with TB notified in 2019. EPTB carries a high risk of mortality and so early diagnosis and treatment are important to reduce this risk. Diagnosis of EPTB in low- and middle-income countrie…
Luong Dinh-Van, Hoang-Anh Nguyen-Cong, Phuong Duong-Minh, Bich-Ngoc T Nguyen
**BACKGROUND:** Thoracic amyloidosis is a rare disorder that often mimics malignancy or chronic infections. In tuberculosis-endemic regions, diagnostic confusion frequently leads to unnecessary empiric treatments. This study was aimed at describing the clinical and radiological c…
Christopher DJ, Esmail A, Scott AJ, Wilson L, Randall P, et al.
Background Tuberculous pleural effusion (TPE) is the most common form of extrapulmonary tuberculosis in many settings. The diagnostic performance of the frontline polymerase chain reaction-based GeneXpert MTB/RIF Ultra (Xpert Ultra) remains suboptimal (sensitivity of ∼30%), but d…
Long Cai, Mingzhi Zhu, Tingting Fang, Qianqian Peng, Lingshan Dai, et al.
**PURPOSE:** To evaluate the diagnostic value of a combined strategy using the urine lipoarabinomannan (LAM) antigen assay and interferon-gamma release assay (IGRA) for active tuberculosis (TB), and to explore its potential as a non-invasive, sputum-independent diagnostic method …
Karthik Balasoupramaniane, Dharm Prakash Dwivedi, Vishnukanth Govindaraj, Noyal Mariya Joseph, Deepak Barathi, et al.
**BACKGROUND:** Tuberculosis (TB) remains a major global health challenge, particularly in developing countries. Non-sputum diagnostic tools are the need of the hour for effective TB diagnosis, especially in paucibacillary and extrapulmonary cases. This study evaluated the diagno…
Chen S, Wang C, Zou Y, Zong Z, Xue Y, et al.
Background Existing diagnostic approaches for paucibacillary tuberculosis (TB) are limited by the low sensitivity of testing methods and difficulty in obtaining suitable samples. Methods An ultrasensitive TB diagnostic strategy was established, integrating efficient and specific …
Shashidhar S Vananjakar, Prasanna Kumar T,, Nirantha S P, Mohammed Sameer Kundale,, Sruthy Vijayan, D, et al.
Introduction Background and Objectives India is an endemic country for TB Tuberculosis(TB), with the pleura being the most common extra pulmonary site affected, followed by lymph nodes. Diagnosing EPTB Extrapulmonary Tuberculosis( EPTB)is as crucial as treating it, since many cas…
Noor AM, Ghazali SM, Bakar ZA, Ruzan IN
Rapid and highly accurate diagnostic tools are critically needed to diagnose Mycobacterium tuberculosis and rifampicin resistance in AFB smear-negative samples. In this study, we evaluated the diagnostic performance of Xpert MTB/RIF Ultra (Ultra) as a rapid test to diagnose tuber…
Miguel Hueda-Zavaleta, Juan Carlos Gómez de la Torre, Claudia Barletta‐Carrillo, Cinthya Flores-Flores, Nilver Piscoche-Botello, et al.
BackgroundTuberculosis (TB) is one of the leading causes of death worldwide. However, an accurate diagnosis contributes to timely treatment, reducing its adverse consequences. The aim of this research was to determine the diagnostic accuracy of the molecular test Xpert MTB/RIF an…
Angharad Davis, Robert J. Wilkinson
Tuberculous meningitis is the most serious manifestation of tuberculosis, with mortality in approximately 50% of HIV co-infected people. 1 Marais S Pepper DJ Schutz C Wilkinson RJ Meintjes G Presentation and outcome of tuberculous meningitis in a high HIV prevalence setting. PLoS…
Dharwadkar A, Ingale Y, Deokar N, Vyawahare C, Vishwanathan V, et al.
Background Extrapulmonary tuberculosis (EPTB) makes for 25% of all instances of tuberculosis (TB) patients. The enigmatic clinical presentation of EPTB makes identification difficult since it simulates other chronic conditions such as neoplastic and inflammatory disorders and cou…
Sneha Singh, Amresh Kumar Singh, Sushil Kumar, Nandini Singh, Ashwini Kumar Mishra, et al.
… Recent molecular and genomic advances have transformed NTM diagnostics by enabling rapid, specific, and high-resolution identification. Line probe assays (e.g., GenoType Mycobacterium CM/AS assay) and multiplex PCR have enhanced the ability to distinguish between NTM species suc…
Madeleine T Dang, Kara Lukas, Daniel H Choi, Timothy J Chu, Vishwanath Venketaraman
Extrapulmonary tuberculosis (EPTB) is an infectious disease characterized by the invasion ofbeyond the lungs. Diagnosis is frequently delayed due to nonspecific clinical presentations that vary by organ system, making diagnostic imaging essential for disease detection, characteri…
Ashima Jamwal, Anjali Swami, Ankita Mohanty, Sujata Baveja
…EPTB) has led healthcare professionals to opt for molecular diagnostics. Despite the availability of rapid diagnostics, conventional culture Drug Susceptibility Testing (DST) is still considered the gold standard in diagnosing TB. Aim: To assess the diagnostic accuracy of culture…