Showing 76–100 of 102 documents
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Apoorva Narain, Surya Kant, Rikesh K. Dubey, Kanchan Srivastava, Anand Kumar Maurya
… diseases. Also, it can aid in the development of effective vaccines as well as simple, rapid, and cost-effective tests for the diagnosis of TB, which are crucial for the management and control of the disease.
…d nowadays in TB drug development. Finally, a summary of TB vaccines that are either approved or undergoing clinical trials concludes the Special Issue.
Olha Konstantynovska, Petro Poteiko, Олександр Зіненко, Anton Rohozhyn, Ivan Hrek, et al.
…containing PrimeStore Molecular Transport Medium® (Longhorn Vaccines & Diagnostics, San Antonio, TX). The isolates were transported from Kharkiv, Ukraine, to San Antonio, TX at ambient temperature. WGS was performed using an Illumina MiSeq platform. Bioinformatics analysis wa…
Budi Yanti, Mulyadi Mulyadi, Soetjipto Soetjipto, Ni Made Mertaniasih, Muhammad Amin
Mycobacterium tuberculosis (MTB) is mostly found in humans, and it can cause more than two million deaths each year with increasing morbidity. Although lineages of MTB show identical nucleotide relationships, they have different characteristics such as evolution, transmission, dr…
Cristina Daniela Marineci, Cristina Elena Zbârcea, Simona Negreș
Tuberculosis is a chronic infection, most often affecting the lungs, which usually manifests after a latency period from primary infection with Mycobacterium tuberculosis. Symptoms are generally nonspecific, with fever, cough, weight loss and malaise. The diagnosis is based on mi…
Richard Stone
North Korea watchers warn that the country’s aggressive measures to defend itself against COVID-19, the illness caused by the novel coronavirus, are hobbling efforts to combat tuberculosis (TB) and other infectious diseases Sandwiched between two COVID-19 hot spots—China and Sout…
Thipkrua N, Disrathakit A, Chongsuvivatwong V, Mahasirimongkol S, Ruangchai W, et al.
…ypic methods. It will also be crucial to ensure that future vaccines and/or recommended chemoprophylaxis therapy for MDR-TB will provide protection against these emerging strains.
Mohsen Heidary, Saeed Zaker Bostanabad, Amini SM, Ameneh Jafari, Ghalami Nobar M, et al.
Mohsen Heidary,1,2 Saeed Zaker Bostanabad,3,4 Seyed Mohammad Amini,5 Alireza Jafari,6 Mostafa Ghalami Nobar,4,7 Arash Ghodousi,8 Morteza Kamalzadeh,9 Davood Darban-Sarokhalil1 1Department of Microbiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran; 2Stu…
Amish Talwar, Clarisse A. Tsang, Sandy F. Price, Robert Pratt, William L. Walker, et al.
This report reviews the current status of tuberculosis in the United States, noting the declining incidence and describing the populations with the greatest prevalence. This report reviews the current status of tuberculosis in the United States, noting the declining incidence and…
Snehlata Yadav, Balasubramanian Narasimhan
Background: Tuberculosis, an infectious disease caused mainly by the Mycobacterium tuberculosis accounts for the highest number of deaths worldwide. Despite curing millions, the currently used drug regimens are bounded by various limitations such as long course of therapy, emerge…
Peter J. Holmberg, Zelalem Temesgen, Ritu Banerjee
1. Peter J. Holmberg, MD* 2. Zelalem Temesgen, MD† 3. Ritu Banerjee, MD, PhD‡ 1. *Division of Pediatric Hospital Medicine, Department of General Pediatric and Adolescent Medicine, and 2. †Division of Infectious Disease, Mayo Clinic, Rochester, MN 3. ‡Division of Pediatric Infecti…
Ying Zhang
Tuberculosis (TB) remains a leading infectious disease globally despite the use of chemotherapy and the BCG vaccine. The increasing emergence of multidrug-resistant/extensively drug-resistant TB (MDR/XDR-TB) poses a major threat to the effective control of TB. A brief overview of…
Ted Lankester
Abstract This chapter describes the recent status, impact, and control of tuberculosis (TB) worldwide through the End TB strategy. It gives examples of how government and civil society programmes can work together, with the roles and tasks of each clearly defined. It gives exampl…
Xinen Kong, Jiayi Yang, Jiajun Wang, Jiaxiang Li, Xiaoying Jin, et al.
…mmunodeficiency virus (HIV) co-infection, lack of effective vaccines and diagnosis methods, as well as the low treatment efficacy of anti-TB therapeutics lead to multiple difficulties and challenges in TB control. Host immune defense is critical for the processes and outcome of M…
Omid Nikjeh, Seyedehparmis Rejali, Kayvan Sasaninia, Vishwanath Venketaraman
…uding interferon-γ, GM-CSF, and IL-7; and therapeutic vaccines (M72/AS01E, MTBVAC, VPM1002) as promising adjuncts. Distinct from guideline-focused overviews, this review emphasizes non-tuberculous mycobacterial disease (NTM, including MAC) and leprosy in PLWH and synthesize…
Muluneh Assefa, Mitkie Tigabie, Azanaw Amare, Getu Girmay, Alene Geteneh, et al.
**INTRODUCTION:** The growing challenge of antimicrobial resistance in Ethiopia and itsprogression towards XDR and PDR has become a critical public health concern. Therefore, thisreview determined the current state of emerging XDR and PDR bacteria, including pre-XDR and XDR-TB, t…
Saxena A, Bhagra S, Das S, Kaushik N, Saha B
TB remains a significant global health burden due to protracted therapeutic courses, poor patient compliance, and toxicities associated with drug treatment, as well as concerns arising from increasingly prevalent multidrug-resistant and extensively drug-resistant strains of M. tu…
World Health Organization. Regional Office for Europe
…ch in basic sciences, new diagnostic tools, novel drugs and vaccines; and 3. operational and public health research. This study is intended to provide a prioritized research agenda for TB in the WHO European Region to guide implementation research and strengthen evidence-based TB…
Md Zamiur Rahaman, Tahmina Alam, Syeda Shamsun Nahar, Ridwana Nahrin, Israt Jahan Bushra, et al.
**OBJECTIVE:** This scoping review aims to identify and map the available evidence on interventions for the prevention and treatment of childhood TB, confirm current practice, explore variation, and identify emerging approaches. **STUDY DESIGN:** Scoping review. **METHOD:** Thi…
Pulak Pritam, Sreelipta Das, Sandeep Kumar Behera, Monali Sahoo, Lopamudra Subudhi, et al.
The disease tuberculosis, caused by, is one of the leading causes of global human mortality. The rise of multidrug and extensively drug-resistant strains of the pathogen and the limited efficacy of the BCG vaccine is one of the major concerns worldwide. Conventional chemotherapy …
Parissa Farnia, Ali Akbar Velayati, Jalaledin Ghanavi, Poopak Farnia
…olds promise for the development of innovative diagnostics, vaccines, and antiadhesin therapies aimed at combating both drug-sensitive and drug-resistant tuberculosis.
Parissa Farnia, Ali Akbar Velayati, Jalaledin Ghanavi, Poopak Farnia
…ng years of progress. Despite the availability of effective vaccines and treatment regimens, gaps in awareness, funding, healthcare infrastructure, and social determinants of health hinder global elimination efforts. Coordinated, multisectoral strategies are essential to address …
Edmund K. Waller, MD, PhD, FACP
The purpose of this study is to evaluate the safety, pharmacokinetics, and effects of imatinib on myelopoiesis in adults when given with and without isoniazid and rifabutin. The results of this trial will determine the imatinib dose to be studied in a subsequent Phase IIB treatme…
Clifton Barry, Ph.D.
This study, conducted in Masan and Seoul, South Korea, investigated the effectiveness of linezolid (LZD) in treating patients with extensively drug resistant tuberculosis (XDR TB). Because regular medicines do not work well against XDR TB, many more people die from it than from r…
Zumla, Alimuddin, Wallis, Robert, Klein, Nigel, Oleson, Ole, Lang, Hannu, et al.