Showing 76–100 of 200 documents
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Mao LR, Du JP, Wang XC, Xu LF, Zhang YP, et al.
The resuscitation of dormant Mycobacterium tuberculosis is an important cause of adult tuberculosis (TB) transmission. According to the interaction mechanism between M. tuberculosis and the host, the latency antigen Rv0572c and region of difference 9 (RD9) antigen Rv3621c were se…
Fatima Abbas Khalid, Muataz Mohamed Eldirdery, Maowia M. Mukhtar
Abstract Background Tuberculin skin test (TST) is a delayed hypersensitivity reaction of latent TB infected patients and BCG vaccinated individuals. It is recommended for screening of mycobacterium infection in many countries. Kassala state in eastern Sudan is known as the highes…
Singh M, Mehendale S, Guleria R, Sarin R, Tripathy S, et al.
…dia that aims to evaluate the efficacy and safety of two TB vaccines; namely, VPM1002 and Immuvac ( M.w ) ( Mycobacterium Indicus Pranii ) (MIP) among healthy household contacts (HHCs) of sputum smear-positive pulmonary TB (PTB) patients. Methods and analysis In the three-arm ran…
Vergara EJ, Tran AC, Kim MY, Mussá T, Paul MJ, et al.
…sal administration of spore- and nanoparticle-based subunit vaccines. Analysis of lung T cell responses revealed an increasing trend in the frequency of important CD4 and CD8 T cell subsets, and T effector memory cells with a Th1 cytokine (IFNγ and TNFα) signature among immunised…
Kumarasamy N, Poongulali S, Beulah FE, Akite EJ, Ayuk LN, et al.
Objectives To assess the long-term safety and immunogenicity of the M72/ Adjuvant System (AS01E) candidate tuberculosis (TB) vaccine up to 3 years post-dose 2 (Y3) in human immunodeficiency virus (HIV)-positive (HIV+) and HIV-negative (HIV-) Indian adults. Methods This phase II, …
Jiang F, Peng C, Cheng P, Wang J, Lian J, et al.
Background: Latent tuberculosis infection (LTBI) is the primary source of active tuberculosis (ATB), but a preventive vaccine against LTBI is lacking. Methods: In this study, dominant helper T lymphocyte (HTL), cytotoxic T lymphocyte (CTL), and B-cell epitopes were identified fro…
Brinkmann F, Friedrichs A, Behrens GM, Behrens P, Berner R, et al.
Background Vulnerability to infectious diseases in refugees is dependent on country of origin, flight routes, and conditions. Information on specific medical needs of different groups of refugees is lacking. We assessed the prevalence of infectious diseases, immunity to vaccine-p…
Coppola M, Ottenhoff TH
…e available to monitor the response of TB to treatment. New vaccines are also urgently needed to substitute or boost Bacille Calmette-Guérin (BCG), the only approved TB vaccine: although BCG prevents disseminated TB in infants, it fails to impact the incidence of pulmonary TB in …
Jiang F, Han Y, Liu Y, Xue Y, Cheng P, et al.
…nsistent efficacy, highlighting the need for more potent TB vaccines. Materials and methods In this study, we employed reverse vaccinology techniques to develop a promising multi-epitope vaccine (MEV) candidate, called PP13138R, for TB prevention. PP13138R comprises 34 epitopes, …
Manika Sharma, Devanshu Kumar, Ayushi Kaur Bedi, Pooja Yadav, Parul Bhatt, et al.
… for TB infection. Over the past few years, protein subunit vaccines have gained research attention due to their safety and versatility. This study aimed to assess the protective efficacy of an immunoinformatically designed, expressed, and purified synthetic peptide vaccine candi…
Laura Mateu-Arrom, Lluis Puig
…general population, including annual influenza and COVID-19 vaccines. Live-attenuated vaccines are generally advised against in patients undergoing biologic treatment. However, some live-attenuated vaccines may be safely administered under specific circumstances with IL-17 or IL-…
Sudhasini Panda, Jeffrey Morgan, Catherine Cheng, Mayuko Saito, Robert H. Gilman, et al.
…he challenge in advancing tuberculosis (TB) diagnostics and vaccines arises from our limited understanding of diverse Mtb antigens triggering distinct T cell responses in spectrum of TB infection. We addressed this with a comprehensive analysis, screening 20,610 Mtb-derived T cel…
Seyhoglu E, Uyaroğlu OA, Erden A, Kilic L, Karadag O, et al.
Objectives The Turkish population is vaccinated with Bacille Calmette-Guérin (BCG), and the BCG vaccination decreases the specificity of the tuberculin skin test (TST). The purpose of this study was to investigate the incidence of active tuberculosis (TBC) among rheumatic patient…
André S Nell, MD, Pere Joan Cardona, MD, PhD
The aim of the trial is to assess the safety, tolerability and immunogenicity of two doses of RUTI® vaccine administered four weeks apart after one month pre-treatment with INH. The trial will be double-blinded, randomized and placebo-controlled with 96 subjects (48 HIV- and 48 …
Ong E, He Y, Yang Z
…, Rv3619, Rv3620, and Rv1813) constituting five MTB subunit vaccines (M72, H1, H4, H56, and ID93) that are currently in clinical trials. We also assessed the promiscuity of the predicted epitopes based on a reference set of alleles and supertype alleles, and estimated the populat…
Mao L, Xu L, Wang X, Xing Y, Wang J, et al.
COVID-19 has affected the progress made in the prevention and treatment of tuberculosis (TB); hence, the mortality of tuberculosis has risen. Different strategies-based novel TB vaccine candidates have been developed. This study identifies strategies to overcome the limitations o…
Carabali-Isajar ML, Ocampo M, Rodriguez DC, Vanegas M, Curtidor H, et al.
Mycobacterium tuberculosis is considered one of the most successful pathogens in the history of mankind, having caused 1.7 million deaths in 2016. The amount of resistant and extensively resistant strains has increased; BCG has been the only vaccine to be produced in more than 10…
Shunli Cai, Tianwei Yan, Yutian Yang, Xin Guo, Xiang Li, et al.
**BACKGROUND:** Bacillus Calmette-Guérin (BCG) vaccination is well established for preventing severe tuberculosis (TB) in children; however, its effectiveness in reducing the progression of latent TB infection (LTBI) to active disease remains uncertain, particularly in real-…
Tait DR, Hatherill M, Van Der Meeren O, Ginsberg AM, Van Brakel E, et al.
Background Results of an earlier analysis of a trial of the M72/AS01 E candidate vaccine against Mycobacterium tuberculosis showed that in infected adults, the vaccine provided 54.0% protection against active pulmonary tuberculosis disease, without evident safety concerns. We now…
Zhiming Hu, Shaohua Guo, Wenlong Chen, Jiangshan Ouyang, Chunxu Huang, et al.
Latent tuberculosis infection (LTBI), affecting nearly one-quarter of the global population, represents a major barrier to Tuberculosis (TB) eradication and a paradigm of chronic infectious disease. Current chemotherapeutic regimens for TB, although effective, are limited by drug…
Rai PK, Chodisetti SB, Maurya SK, Nadeem S, Zeng W, et al.
Background The clinical trials conducted at Chingleput India suggest that BCG fails to protect against tuberculosis (TB) in TB-endemic population. Recent studies advocate that non-tuberculous mycobacteria and latent Mycobacterium tuberculosis (Mtb) infection interferes in the ant…
Teahan B, Ong E, Yang Z
Tuberculosis (TB) is the leading cause of death of any single infectious agent, having led to 1.4 million deaths in 2019 alone. Moreover, an estimated one-quarter of the global population is latently infected with Mycobacterium tuberculosis (MTB), presenting a huge pool of potent…
Syggelou A, Spyridis N, Benetatou K, Kourkouni E, Kourlaba G, et al.
The Bacille Calmette-Guérin (BCG) vaccine has been shown to provide considerable protection against miliary or meningeal tuberculosis (TB), but whether it prevents other forms of disease remains controversial. Recent evidence has shown that the BCG vaccine also provides protectio…
Shabariah R, Farsida, Hatta M, Patellongi I, Idris I, et al.
Background How far the role of innate immunity and adaptive immunity do in children who have been BCG vaccinated in controlling the course and the severity of the TB disease has not been completely known. Mycobacterium tuberculosis entry to the body will be recognized by Toll-lik…
Wilkie MEM
Tuberculosis is the leading single infectious disease killer in the world, and the global burden of LTBI and TB disease, with the addition of antimicrobial drug resistance means there is a desperate need for a safe and effective TB vaccine. BCG is the only licensed vaccine and ex…