Showing 76–100 of 200 documents
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University of Colorado, Denver
… recommended treatment guideline consists of four treatment regimens, varying in duration from 3 to 9 months. The CDC recommends utilization of the shorter regimens when possible to achieve higher patient compliance and infection clear rates. The second shortest duration treatmen…
Elsa M Villarino, MD, MPH, Timothy Sterling, MD
Open-label, multi-center, Phase III clinical trial to compare the effectiveness and tolerability of a three-month (12-dose) regimen of weekly rifapentine and isoniazid (3RPT/INH) to the effectiveness of a nine-month (270-dose)regimen of daily isoniazid (9INH) to prevent tuberculo…
Gaensbauer J, Aiona K, Haas M, Reves R, Young J, et al.
…tuberculosis infection (LTBI) to active disease. Therefore, regimens for treatment of pediatric LTBI must be not only efficacious but practical enough to overcome the unique childhood barriers to regimen adherence. Since 2012, a 4-month regimen of daily rifampin (4R) has been the…
Richard E. Chaisson, MD, Susan Swindells, MBBS
HIV-infected people have an increased risk of developing active tuberculosis (TB). At the time the study was designed, the standard course of treatment for TB was 6 to 9 months of isoniazid (INH).This study compared the safety and effectiveness of a 4-week regimen of rifapentine …
Kaushik A, Ammerman NC, Tyagi S, Saini V, Vervoort I, et al.
…3 weeks after challenge infection with one of the following regimens: an untreated negative-control regimen; positive-control regimens of daily rifampin (10 mg/kg of body weight), once-weekly rifapentine (15 mg/kg) and isoniazid (50 mg/kg), or daily bedaquiline (25 mg/kg); test r…
Richard Chaisson, MD
…study compares three different tuberculosis (TB) prevention regimens against the standard regimen of 6 months of isoniazid. It is being conducted in Soweto, South Africa. People who are HIV positive and have a positive tuberculin skin test without signs of active tuberculosis may…
Dick Menzies, MD
…ared the rates of serious adverse events (SAE) with the two regimens. These were adjudicated by an independent three member review panel, blinded to study drug. In this phase, among 420 subjects randomized to 4RIF overall rate of Grade 3-4 SAE was 2.4% compared to 5.6% among the …
Ying He, Yan Deng, Hai Yi
Dear Editor, A 63-year-old male was diagnosed with acute myeloid leukemia (AML-M2, AML-ETO fusion gene positive, ASXL1 mutation frequency 39%, chromosomal karyotype analysis: 45, X, -Y, t(8;21)(q22;q22), del(9)(q13q32)[19]/46, XY [1]) in June 2021 with multiple enlarged lymph nod…
lifan zhang, Yujie He, W. Wang, lijun wu, Zuo Xx, et al.
…andomized noninferiority trial comparing a modified 3-month regimens of twice weekly RFT at 450mg plus daily INH at a maximum dose of 300mg (3HP-PUMCH) versus 9-month daily isoniazid at a maximum dose of 300mg (9H) in patients with RDs. Subjects were enrolled from 9 tertiary hosp…
Yixuan Yang, Feiran Zhou, Yanfei Ren, Fudong Li, Qingluan Yang, et al.
…BI) and subsequent TB preventive treatment (TPT). Major TPT regimens require ≥3 months of drug exposure and demonstrate suboptimal safety profiles, significantly compromising treatment completion rates. The development of shorter, safer chemoprophylaxis strategies therefore repre…
О. Д. Баронова, Valentina Aksenova, Н. И. Клевно, В. С. Одинец, О. В. Пилипенко
… and medical cost effectiveness of different LTBI treatment regimens in children and adolescents. Subjects and methods . 205 children in the age from 6 to 17 years old with latent tuberculosis infection were included in the study: The main (prospective) group included 31 children…
В. Е. Новиков, Natalia E. Usacheva, Natalia S. Ponamareva, T. V. Myakisheva
… efficiency of the applied methods of immunodiagnostics and regimens of chemoprophylaxis of tuberculosis in children is shown. To improve the epidemic situation of tuberculosis among children, it is important to improve preventive chemotherapy regimens. Their effectiveness is lar…
C. Shu, Chien‐Chia Chen, Chia‐Hsuin Chang, Chih‐Yuan Lee, Jann-Yuan Wang, et al.
…were analysed among those initially without LTBI. Treatment regimens of LTBI were analysed for completion and adverse effects. RESULTS: Of 276 KTRs enrolled, 31 (11.2%) had initial positive QFT results, which were significantly associated with cirrhosis of the liver, radiographic…
Huashan Hospital
The purpose of this study is to assess the efficacy, safety and tolerability of the 1-month regimen of three times weekly rifapentine plus isoniazid in improving fertility outcome in recurrent implantation failure (RIF) patients with latent genital tuberculosis (LGTB), compared t…
Peck GM, Staat MA, Huang FS, Khalil N, Boyce C, et al.
Background Effective yet safe treatment of latent tuberculosis is important for preventing the spread of tuberculosis and the progression to active disease in pediatric patients. As of 2017, the short course combination regimen of weekly isoniazid and rifapentine (3HP) administer…
Yong Li, Linlin Song, Ying Zhang, Zhenzhou Feng, Feng Sun, et al.
…rospectively enrolled and treated with the all-oral shorter regimens or the standard injectable-containing shorter regimen. We collected peripheral blood samples from participants before treatment (pre-treatment), at the first negative smear (smear conversion), and at the end of …
Sonya Krishnan, Robin Avery, Veronica Dioverti, Jeffrey A Tornheim
…. Evidence indicates that short-course, rifamycin-based TPT regimens are associated with less hepatoxicity and improved treatment completion compared to isoniazid. In the transplant population, however, drug-drug interactions limit their use, so isoniazid preventive therapy remai…
Heyd A, Heffernan C, Storey K, Wild TC, Long R
…e doses of medication over an extended period of time. Such regimens are associated with poor adherence and completion rates. A shortened treatment regimen of once weekly isoniazid plus rifapentine for 3 months (3HP), is now available, and holds promise in populations facing chal…
Chin-Chung Shu, Chien-Chia Chen, Chin-Hao Chang, Chih-Yuan Lee, Jann-Yuan Wang, et al.
…were analysed among those initially without LTBI. Treatment regimens of LTBI were analysed for completion and adverse effects. **RESULTS:** Of 276 KTRs enrolled, 31 (11.2%) had initial positive QFT results, which were significantly associated with cirrhosis of the liver, radiogr…
Solé A, Part-Lopez M, Saez B, Laporta R, Anguera G, et al.
… outcome between rifampicin (RIF) versus non-RIF containing regimens were analyzed. Methods Multicenter, observational retrospective study, including all cases of TB diagnosed in recipients after LT, in five pulmonary transplant units in Spain, between January 1990 and December 2…
Shu CC, Chen CC, Chang CH, Lee CY, Wang JY, et al.
…were analysed among those initially without LTBI. Treatment regimens of LTBI were analysed for completion and adverse effects. Results Of 276 KTRs enrolled, 31 (11.2%) had initial positive QFT results, which were significantly associated with cirrhosis of the liver, radiographic …
Walker WL, Schmit KM, Welch EC, Vonnahme LA, Talwar A, et al.
…ese data further support preferential use of shorter-course regimens such as INH + RPT.
Alimuddin Zumla, Jeremiah Chakaya, Mishal Khan, Razia Fatima, Christian Wejse, et al.
…orld's population and that despite effective oral treatment regimens being available, scale-up and rollout of TB preventive treatment (TPT) remains limited. They describe strategies to support scale-up of TPT in high-prevalence settings, where the potential benefit for affected i…
Pease C, Hutton B, Yazdi F, Wolfe D, Hamel C, et al.
…ar or lesser rates of adverse events compared to other LTBI regimens, namely INH for 9 months, INH for 6 months, rifampin for 3 to 4 months, and rifampin plus INH for 3 to 4 months. Methods We searched MEDLINE, Embase, CENTRAL, PubMed, ICTRP, clinicaltrials.gov, and Canadian Agen…
Iwata K, Morishita N, Nishiwaki M, Miyakoshi C
…y of tuberculosis. A shorter regimen is preferred to longer regimens because the former has better adherence with a better safety profile. However, lengthy treatment with isoniazid is still recommended in Japan. Based on the latest evidence, we switched from a conventional nine-m…