Showing 76–100 of 200 documents
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Ramachandran G
…cycloserine, pyrazinamide and ethambutol. In the absence of pediatric friendly tablets/formulations, in most cases the adult tablets are either crushed or broken. This is likely to lead to inaccurate dosing. Very limited information is available on the pharmacokinetics of second-…
Jyoti S. Mathad, Sylvia M. LaCourse, Amita Gupta
…tored investigator with the IMPAACT (International Maternal Pediatric Adolescent AIDS Clinical Trials Network) TB Scientific Committee, co-leads the Advocacy Arm of the International Union Against TB and Lung Disease Maternal Child Health Working Group and the Pregnancy Working G…
Aqeela Iqbal, Muhammad Ashraf, Ahsan Waheed Rathore, Muhammad Ovais Omer, Aftab Ahmad Anjum, et al.
…y pattern of Mycobacterium tuberculosis (MTB) isolates from pediatric patients. A total number of 1718 pediatric patients suspected of Mycobacterium tuberculosis were enrolled in the Institute of Child Health and Children's Hospital, Lahore during 2016-17. Out of 1718, only 710 d…
Burkhardt, Ingrid, Goetzinger, Florian, Iipumbu, Lahia, Whittaker, Elizabeth, Günther, Gunar, et al.
…atment strategies. Areas Covered We present current data on pediatric and adolescent MDR-TB combined with expert opinion to guide the reader through the pediatric and adolescent MDR-TB care cascade. This includes background information and practical guidance on the disease, the e…
Dhruv Gandhi, Ira Shah
…Xpert Ultra, and Xpert MTB/XDR, are critical for diagnosing pediatric tuberculosis (TB) and detecting drug resistance. However, rifampicin indeterminate (RI) results, particularly in samples with trace Mycobacterium tuberculosis (MTB) load, pose a clinical challenge. Current guid…
Geweniger A, Janda A, Eder K, Fressle R, Kannan CV, et al.
…crobiological diagnosis of pulmonary tuberculosis (Tb) in a pediatric population is hampered by both low pathogen burden and noncompliance with sputum sampling. Although endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) has been found useful for the eva…
Carrie Tudor, Jason E. Farley, Martie van der Walt, Susan E. Dorman, William Pan, et al.
… wards (incidence rate ratio [IRR] 2.03, 95% CI 1.11-3.71), pediatric wards (IRR 1.82 95% CI 1.07-3.10), outpatient departments (IRR 2.08 95% CI 1.23-3.52), and stores/workshop (IRR 2.38 95% CI 1.06-5.34) compared with those without such a history. HCWs living with HIV had a grea…
van der Laan LE, Garcia-Prats AJ, McIlleron H, Abdelwahab MT, Winckler JL, et al.
… adults given 500 mg daily terizidone, 2022 WHO-recommended pediatric doses result in lower exposures in weight bands 3-10 kg and 36-46 kg. We developed a population pharmacokinetic model in children for cycloserine dosed as terizidone and characterized the effects of body size, …
Verkuijl S, Sekadde MP, Dodd PJ, Arinaitwe M, Chiang SS, et al.
…number estimated to have TB. Accurate data on the burden of pediatric TB is essential to guide action. Despite several improvements in estimating the burden of pediatric TB in the last decade, as well as enhanced data collection efforts, several data gaps remain, both at the glob…
Denti P, Garcia-Prats AJ, Draper HR, Wiesner L, Winckler J, et al.
…ultidrug-resistant tuberculosis (MDR-TB). There are limited pediatric pharmacokinetic data to inform dose selection for children. Children routinely receiving levofloxacin (250-mg adult tablets) for MDR-TB prophylaxis or disease in Cape Town, South Africa, underwent pharmacokinet…
Seddon JA, Johnson S, Palmer M, van der Zalm MM, Lopez-Varela E, et al.
…nostic and therapeutic developments in adults have improved pediatric management, yet further pediatric-specific research and wider implementation of evidence-based practices are required. Areas covered This review combines the most recent data with expert opinion to highlight be…
Xiaomeng Hu, Changhao Cheng, Qian Jin, Wu Jin, Qiaoyan Dong, et al.
…d significant lesion resolution in all cases, including the pediatric lymph node involvement (first reported in China). Twenty-four adverse events occurred (15 Grade 1, 6 Grade 2, 3 Grade 3), primarily corrected QT interval prolongation (5 events, one > 500 ms). Mo…
Ingrid Burkhardt, Florian Götzinger, Lahia Iipumbu, Elizabeth Whittaker, Gunar Günther, et al.
… strategies. **AREAS COVERED:** We present current data on pediatric and adolescent MDR-TB combined with expert opinion to guide the reader through the pediatric and adolescent MDR-TB care cascade. This includes background information and practical guidance on the disease, the e…
Harausz EP, Garcia-Prats AJ, Law S, Schaaf HS, Kredo T, et al.
…ment for these children. Methods and findings To inform the pediatric aspects of the revised World Health Organization (WHO) MDR-TB treatment guidelines, we performed a systematic review and individual patient data (IPD) meta-analysis, describing treatment outcomes in children tr…
Rabyya Jameel, Naima Mehdi, Nadia Majeed, Aizza Zafar, Anum Tahir, et al.
…ess the prevalence of rifampicin resistance in samples from pediatric patients in Pakistan, encompassing both pulmonary and extra-pulmonary cases using GeneXpert MTB/RIF assay. Methods: A cross-sectional study was conducted in the Children’s Hospital, Lahore for a duration of six…
Iqbal A, Ashraf M, Rathore AW, Omer MO, Anjum AA, et al.
…y pattern of Mycobacterium tuberculosis (MTB) isolates from pediatric patients. A total number of 1718 pediatric patients suspected of Mycobacterium tuberculosis were enrolled in the Institute of Child Health and Children's Hospital, Lahore during 2016-17. Out of 1718, only 710 d…
Muthia Rakha Yasyfa, Fajar Awalia Yulianto, Raden Ganang Ibnusantosa
…arch keywords (multidrug-resistant OR MDR) AND (children OR pediatric). The articles central to this research were sourced from the WHO Global Report 2023, CDC, EBSCO, Elsevier, Lancet, and PubMed, totaling twenty seven articles. Results indicate that in 2019, there were over 360…
Nori H, Vohra V, Banday AZ, Jindal AK, Tyagi R, et al.
…oimmune syndrome (MAIS) is increasingly being recognized in pediatric clinical practice, often in conjunction with systemic lupus erythematosus (SLE). Besides multi-organ autoimmunity, children with SLE are often at a higher risk of developing infections including tuberculosis. T…
Tristram D, Tobin EH
…urden countries and pockets throughout the developed world. Pediatric TB case rates are likely underreported in many high-burden countries, and study results have suggested that children may represent as many as 50% of TB cases worldwide.[WHO 2023 Global TB Report] Much work is n…
Korzeniewska-Koseła M
…nd i.e. 0.6 per 100 000. In the whole country there were 52 pediatric cases of tuberculosis. TB in children represented 0.9% of all cases notified in Poland in 2018. The incidence rates of tuberculosis were growing along with the age group from 0.9 per 100 000 among children to 2…
Z.I. Pіskur, L.І. Pylypiv, O.M. Shvets, O.P. Kostyk, M.І. Sakhelashvili
Pediatric tuberculosis (TB) is a serious infectious disease that affects many children worldwide and is more likely to be extrapulmonary than adult TB. The purpose - to analyze the profile of drug resistance of Mycobacterium tuberculosis and clinical features of extrapulmonary re…
Rafael Jiménez Alés
…ctious Diseases Society of America guidelines.4,5 Data from pediatric cohorts confirm its efficacy and manageable safety profile under adequate monitoring.6,7 Premature discontinuation of linezolid due to a benign mucosal reaction could compromise therapeutic success in a potenti…
Mane SS, Janardhanan J, Pustake M, Ali MK, Khan GI
…his study, we have discussed patterns of drug resistance in pediatric CNS-TB. Materials and methods Prospective observational study conducted on 100 children at a tertiary care center. Diagnosed cases of CNS-TB were enrolled. GeneXpert MTB/RIF was used upfront for diagnosis, and …
Scott K Heysell, MD
…s in severe TB syndromes (including multidrug-resistant TB, pediatric TB, TB sepsis and TB meningitis) from diverse geographies (including Tanzania, Uganda, Bangladesh, and Siberia) and correlate these findings to TB treatment outcome (TB treatment failure: death/ default/ relaps…
Vijay Sharma, Richa Sharma
…miliary TB or pericardial TB were reported. Patients in the pediatric age group were 2%, aged 15 to 45 years 13%, 46 to 60 years 3% and > 60 years 2.5%. The most common types of EPTB are pleural (20.6%), lymphatic (18%), and abdominal (16.3%). The study suggests that 15- —to 4…