Showing 76–100 of 200 documents
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VN Azger Dusthackeer
Fluoroquinolone resistance is a major challenge in treating Multidrug‑Resistant Tuberculosis globally. The GenoType MTBDRsl Ver 2.0, endorsed by the WHO, was used to characterize fluoroquinolone resistance. The fluoroquinolone resistance rates in the MDR‑TB, Rifampicin‑Resistant …
Tanzila K. Chowdhury, Laurence A. F. Park, Glenn Stone, Mark M. Tanaka, Andrew Francis
…lly and is exacerbated by a growing problem with antibiotic drug resistance. To control the spread of such resistance, it is important for public health authorities to know whether drug-resistant strains in their population have arisen from the ineffective treatment of a previous…
He CJ, Wan JL, Luo SF, Guo RJ, Paerhati P, et al.
Purpose This study aims to compare drug resistance and detection efficacy across different Mycobacterium tuberculosis lineages, offering insights for precise treatment and molecular diagnosis. Methods 161 strains of Mycobacterium tuberculosis ( M.tb) were tested for drug resistan…
Bibi Razia Bano, Farrah Pervaiz, Humaira Mahmood, Rubab Zulfiqar, M. SAMAD, et al.
Pakistan is the world's fifth-highest Drug-Resistant Tuberculosis burden region. However, it is difficult to evaluate the setback of COVID-19 when concurrent tuberculosis is excluded in patients from Pakistan, where the national burden of tuberculosis and drug-resistant tuberculo…
Abhishek Kumar
…e of all the available antibiotics bacteria developed multi-drug resistance (MDR) against the available antibiotics. Mycobacterium is evolved to sustain in wide range of external environment due to biofilm formation. Biofilm is form due to the quorum sensing in the bacteria. The …
ELIZAVETA I. GORDEEVA, P. N. Filippov, Natalia V. Tursunova, Alexey V. Salmin
Background: The spread of M. tuberculosis drug resistance to fluoroquinolones poses a threat to their long-term clinical efficacy. Understanding the mechanisms of formation of drug resistance to fluoroquinolones, based on information on genes associated with drug resistance of M.…
Clifton E Barry, Ph.D.
… determine the relationship between the concentration of TB drugs in plasma and sputum over time. Eligibility: People ages 18 and older who have TB or NTM infection that is suspected to be drug resistant. They must be taking TB or NTM medicines. Design: Participants will be s…
Nguyen TNA, Anton-Le Berre V, Bañuls AL, Nguyen TVA
Drug-resistant tuberculosis is a global health problem that hinders the progress of tuberculosis eradication programs. Accurate and early detection of drug-resistant tuberculosis is essential for effective patient care, for preventing tuberculosis spread, and for limiting the dev…
С. А. Стерликов, I. А. Vаsilyevа, Yu. V. Mikhaylova, В. Г. Кудрина, V. V. Testov
…Health about results of microbiological diagnostics and MTB drug susceptibility tests were studied. To assess the incidence of pre-extensive drug resistance, general population data were used, and for extensive drug resistance, data from 8 regions of Russia were used. Results . T…
Xiang Li, Guoli Li, Jing Yang, Guangjie Jin, Yuting Shao, et al.
Dapsone (DDS), Rifampicin (RIF) and Ofloxacin (OFL) are drugs recommended by the World Health Organization (WHO) for the treatment of leprosy. In the context of leprosy, resistance to these drugs occurs mainly due to mutations in the target genes (Folp1, RpoB and GyrA). It is imp…
Yang Y, Walker TM, Kouchaki S, Wang C, Peto TEA, et al.
Antimicrobial resistance (AMR) poses a threat to global public health. To mitigate the impacts of AMR, it is important to identify the molecular mechanisms of AMR and thereby determine optimal therapy as early as possible. Conventional machine learning-based drug-resistance analy…
Wing Wai Yew, Denise Pui Chung Chan, Kwok Chiu Chang, Ying Zhang
Escalation of drug resistance in Mycobacterium tuberculosis ( MTB ) furnishes a formidable challenge to the global control of tuberculosis (TB) (1). Delineation of the underlying mechanisms of anti-TB drug resistance is germane to the discovery of strategies in tackling this worl…
Han YR, Wang TH, Gong WP, Liang JQ, An HR
…nical efficacy of thymopentin combined with antituberculous drugs in treating drug-resistant pulmonary TB (PTB). Methods Relevant studies were retrieved from PubMed, Embase, Cochrane Library, Chinese Biomedical Literature Database, CNKI, and Wanfang Database. STATA software was u…
Sofie Marijke Braet, Agathe Jouet, Alexandra Aubry, Magalie Van Dyck-Lippens, Esteban Lenoir, et al.
…tment, leprosy persists in the Comoros. As of May, 2022, no resistance to anti-leprosy drugs had been reported, but there are no nationally representative data. Post-exposure prophylaxis (PEP) with rifampicin is offered to contacts of patients with leprosy. We aimed to conduct a …
Mariner-Llicer C, Goig GA, Zaragoza-Infante L, Torres-Puente M, Villamayor L, et al.
…rtant means to detect Mycobacterium tuberculosis , identify drug-resistant strains and ensure treatment success. Currently employed techniques to diagnose drug-resistant tuberculosis include slow phenotypic tests or more rapid molecular assays that evaluate a limited range of dru…
Huijun Guo, Yanqin Yu, Jin-qi Hao, Lan Zhang, Mingyuan Hao
…Objective. This study aimed to improve the understanding of drug-resistant tuberculosis (TB) by conducting a retrospective analysis of clinical data from TB patients in Hulunbuir, Inner Mongolia, collected between 2015 and 2017. Methods. A retrospective analysis was performed on …
Ali M, Alhowady F, Munir W, Almaslamani M, Alkhal A, et al.
Abstract Background Drug-resistant tuberculosis (DR-TB) is an important issue for public health. This study was conducted to evaluate the characteristics, treatment outcome, and risk factors associated with 223 DR-TB cases in the State of Qatar. Methods A descriptive records-base…
N. A. Olofinskaya, D. O. Vinokhodov
… significantly complicates control of disease spread. Multi-drug resistance is often the result of patients' non-compliance with the treatment regimen, very rarely - spontaneous point mutations in the genes of the microorganism. The emergence of resistance in strains of M. tuberc…
Xiuying Chen, Lixia Xu, Fuming Liu, Jie Wu, Liyang Qiu, et al.
ObjectiveTo understand the resistance of to the first-line anti TB drugs in tuberculosis (TB) patients in Lishui, Zhejiang province, and provide reference basis for TB prevention and control. MethodsThe Mycobacterium tuberculosis strains collected from 2013 to 2018 were identifie…
Dlamini MT, Lessells R, Iketleng T, de Oliveira T
…seriously impacted by the emergence and transmission of its drug-resistant forms. Delayed detection and incomplete characterisation of drug-resistant tuberculosis (DR-TB) contributes to morbidity and mortality, and to ongoing transmission of drug-resistant strains. Current cultur…
George Jó Bezerra Sousa, Thatiana Araújo Maranhão, Terezinha do Menino Jesus Silva Leitão, Thereza Maria Magalhães Moreira, Jerffeson Souza, et al.
Objective: to estimate the prevalence of drug-resistant tuberculosis and associated factors. Methods: a retrospective study that evaluated 74,006 cases of tuberculosis registered in the Notifiable Diseases Information System. In the multivariate analysis, the outcome variable “dr…
Tedla K, Berhe N, Mulugeta A, Medhin G, Berhe G, et al.
…dence on the association of treatment initiation delay with drug resistance. Research Aim. To investigate the association of delayed treatment initiation with drug resistance among newly diagnosed TB patients in Tigray, Ethiopia. Methods. We conducted a follow-up study from Octob…
Pratibha Kohli, Ramendra Pati Pandey, Mohan P. Kohli, Salil Bhargava, V. Samuel Raj
…ll unaware of various aspects of management of TB including drug resistant TB. To be able to make an impact on the disease burden we need to understand the knowledge, attitude and practices (KAP) of practitioners, both in government and private sector, towards TB case management.…
Camus Nimmo, James Millard, Kayleen Brien, Sashen Moodley, Lucy van Dorp, et al.
<b>Genetic mutations linked to bedaquiline resistance were found before starting treatment and acquired during treatment in patients with drug-resistant TB and HIV in KwaZulu-Natal, South Africa. Routine bedaquiline resistance testing needs to be accelerated.</b>http://bit.ly/2vn…
Bharti Sachdeva, Nisha Nisha, Nidhi Nidhi
…s of self-instructional module on knowledge regarding multi drug resistancetuberculosis among staff nurses in SGT hospital’’.Material and Methods: An evaluative approach with one group pre-test, post-test design was used for the study. Thepurposive sampling technique was used to …